Activating Transcription Factor 2 (ATF2) antibody

Details for Product No. ABIN649326
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Antigen
Synonyms CHN1, CG12850, CG3749, dATF-2, DmelCG30420, CG30420, CRE-BP1, CREB2, HB16, TREB7, Atf-2, CRE-BP, Creb2, D130078H02Rik, D18875, Tg(Gzma-Klra1)7Wum, mXBP, atf2-A, atf2l, ATF1, ATF2, HFB1-GDNF, HSCR3
Reactivity
Human
(568), (366), (351), (88), (65), (50), (49), (12), (3), (1), (1), (1), (1), (1)
Host
Rabbit
(534), (22), (8), (7)
Clonality
Monoclonal
Conjugate
Un-conjugated
(16), (16), (16), (14), (14), (14), (14), (14), (14), (14), (14), (2), (2), (2)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(362), (235), (149), (140), (111), (102), (79), (34), (17), (11), (10), (10), (6), (3), (3), (2), (1), (1)
Pubmed 4 references available
Quantity 100 μL
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Catalog No. ABIN649326
450.00 $
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Specificity A synthetic peptide corresponding to residues N-terminus of human ATF-2 was used as immunogen. The antibody does not cross-react with other ATF family members.
Alternative Name ATF-2
Background ATF-2 (activating transcription factor-2, CRE-BP1) is a transcription factor that binds the cAMP response element (CRE) and AP-1 response element and is abundantly expressed in the brain. Various forms of cellular stress, including genotoxic agents, inflammatory cytokines, and UV irradiation, stimulate the transcriptional activity of ATF-2 (2). SAPK and p38 MAPK can activate, in response to cellular stress, ATF-2 by phosphorylating this protein at Thr69 and Thr71. Mutations of these sites result in the loss of stress-induced transcription by ATF-2 (2-4).
Synonyms: ATF2, CREB2, CREBP1, Cyclic AMP-dependent transcription factor ATF-2, Activating transcription factor 2,cAMP response element-binding protein CRE-BP1,HB16,Cyclic AMP-responsive element-binding protein 2
Molecular Weight 70 kDA
Gene ID 1386
UniProt P15336
Research Area Translation Factors, Phospho-specific antibodies, Protein Modifications, Transcription Factors, Signaling, Cell Structure
Application Notes IHC: = 1:100, WB: = 1:1000-10000
Comment

Background: ATF-2 (activating transcription factor-2, CRE-BP1) is a transcription factor that binds the cAMP response element (CRE) and AP-1 response element and is abundantly expressed in the brain. Various forms of cellular stress, including genotoxic agents, inflammatory cytokines, and UV irradiation, stimulate the transcriptional activity of ATF-2 (2). SAPK and p38 MAPK can activate, in response to cellular stress, ATF-2 by phosphorylating this protein at Thr69 and Thr71. Mutations of these sites result in the loss of stress-induced transcription by ATF-2 (2-4).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment ATF-2 Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Maekawa, Sakura, Kanei-Ishii et al.: "Leucine zipper structure of the protein CRE-BP1 binding to the cyclic AMP response element in brain." in: The EMBO journal, Vol. 8, Issue 7, pp. 2023-8, 1989 (PubMed).

Livingstone, Patel, Jones: "ATF-2 contains a phosphorylation-dependent transcriptional activation domain." in: The EMBO journal, Vol. 14, Issue 8, pp. 1785-97, 1995 (PubMed).

van Dam, Wilhelm, Herr et al.: "ATF-2 is preferentially activated by stress-activated protein kinases to mediate c-jun induction in response to genotoxic agents." in: The EMBO journal, Vol. 14, Issue 8, pp. 1798-811, 1995 (PubMed).

Gupta, Campbell, Dérijard et al.: "Transcription factor ATF2 regulation by the JNK signal transduction pathway." in: Science (New York, N.Y.), Vol. 267, Issue 5196, pp. 389-93, 1995 (PubMed).

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