ATG7 Autophagy Related 7 Homolog (S. Cerevisiae) (ATG7) antibody

Details for Product No. ABIN649329
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Antigen
Synonyms AO090001000744, atg7, APG7-LIKE, APG7L, GSA7, 1810013K23Rik, Agp7, Apg7l, Atg7l, ATAPG7, ATATG7, ATG7, AUTOPHAGY 7, AUTOPHAGY-RELATED 7, K15I22.10, K15I22_10
Reactivity
Human
(58), (25), (15), (1), (1)
Host
Rabbit
(54), (3), (2)
Clonality
Monoclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(43), (18), (14), (12), (12), (10), (8), (3), (3), (1), (1), (1)
Pubmed 1 reference available
Quantity 100 µL
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Catalog No. ABIN649329
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Specificity A synthetic peptide corresponding to residues near the C-terminus of human Atg7 was used as an immunogen.
Alternative Name Atg7
Background Autophagy is a process of bulk degradation of cytoplasmic components by the lysosome/vacuole and has a significant relationship to several neurodegenerative disorders and myopathies in mammals (1). Apg7 (Atg7) is a unique E1 enzyme which is essential for both the Apg12p- and Apg8p-modification systems, and plays indispensable roles in autophagy (2). A new molecular pathway has been defined in which activation of the receptor-interacting protein (a serine-threonine kinase) and Jun amino-terminal kinase induced cell death with the morphology of autophagy. Autophagic death required Atg7 and beclin 1 and was induced by caspase-8 inhibition (3).
Synonyms: ATG7, APG7L, Autophagy-related protein 7, APG7-like,Ubiquitin-activating enzyme E1-like protein
Molecular Weight 72 kDA
Gene ID 10533
UniProt O95352
Research Area Signaling, Protein Modifications, Autophagy, Cell Structure
Application Notes IHC: = 1:100-250, WB: = 1:10000-50000
Comment

Background: Autophagy is a process of bulk degradation of cytoplasmic components by the lysosome/vacuole and has a significant relationship to several neurodegenerative disorders and myopathies in mammals (1). Apg7 (Atg7) is a unique E1 enzyme which is essential for both the Apg12p- and Apg8p-modification systems, and plays indispensable roles in autophagy (2). A new molecular pathway has been defined in which activation of the receptor-interacting protein (a serine-threonine kinase) and Jun amino-terminal kinase induced cell death with the morphology of autophagy. Autophagic death required Atg7 and beclin 1 and was induced by caspase-8 inhibition (3).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Atg7 Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Tanida, Tanida-Miyake, Komatsu et al.: "Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p." in: The Journal of biological chemistry, Vol. 277, Issue 16, pp. 13739-44, 2002 (PubMed).

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