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Details for Product No. ABIN649330

Ataxia Telangiectasia Mutated (ATM) antibody

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Antigen
Synonyms AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1, AI256621, C030026E19Rik, ATM, Atm, CG6535, Dmel\\CG6535, Tefu, atm, atm/tefu, dATM, tef, Xatm, at1, atdc, tel1, telo1
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Monoclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP)
Pubmed 3 references available
Catalog no. ABIN649330
Quantity 100 µL
Price
450.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Specificity A synthetic peptide corresponding to residues surrounding Serine 1981 of human ATM was used as immunogen.
Alternative Name ATM
Background ATM is a nuclear phosphoprotein involved in Ataxia-telangiectasia (A-T) an autosomal recessive disorder characterized by cerebellar ataxia, immune deficiencies, increased cancer predisposition, chromosomal instability and radiation sensitivity (1-2). This large protein (370 kDa) is involved in genome stability, cellular responses to DNA damage and cell cycle control. More than 100 mutations have been identified so far and are expected to inactivate the ATM protein by truncation or large deletions (3). Defects in ATM contribute to various B cell and T cell Leukemia (4).
Synonyms: ATM, Serine-protein kinase ATM, Ataxia telangiectasia mutated
Molecular Weight 370 kDA
Gene ID 472
UniProt Q13315
Research Area Signaling, Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cancer, Transcription Factors, Chromatin, Neurology, Cell Structure
Application Notes The suggested dilution is: WB: ~~ 1:1000~10000 IP: ~~ 1:50 ICC: ~~ 1:100~250 IHC: ~~ 1:100~250
Comment

Background: ATM is a nuclear phosphoprotein involved in Ataxia-telangiectasia (A-T) an autosomal recessive disorder characterized by cerebellar ataxia, immune deficiencies, increased cancer predisposition, chromosomal instability and radiation sensitivity (1-2). This large protein (370 kDa) is involved in genome stability, cellular responses to DNA damage and cell cycle control. More than 100 mutations have been identified so far and are expected to inactivate the ATM protein by truncation or large deletions (3). Defects in ATM contribute to various B cell and T cell Leukemia (4).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Storage -20 °C
Storage Comment ATM Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Harnden: "The nature of ataxia-telangiectasia: problems and perspectives." in: International journal of radiation biology, Vol. 66, Issue 6 Suppl, pp. S13-9, 1995 (PubMed).

McConville, Byrd, Ambrose et al.: "Paired STSs amplified from radiation hybrids, and from associated YACs, identify highly polymorphic loci flanking the ataxia telangiectasia locus on chromosome 11q22-23." in: Human molecular genetics, Vol. 2, Issue 7, pp. 969-74, 1993 (PubMed).

Westphal, Schmaltz, Rowan et al.: "Genetic interactions between atm and p53 influence cellular proliferation and irradiation-induced cell cycle checkpoints." in: Cancer research, Vol. 57, Issue 9, pp. 1664-7, 1997 (PubMed).

Alternatives for antigen "Ataxia Telangiectasia Mutated (ATM)", type "Antibodies"
Hosts (153), (59), (18), (6), (4)
Reactivities (229), (74), (44), (5), (4), (1), (1)
Applications (142), (68), (54), (48), (43), (40), (33), (12), (10), (7), (3), (2), (2)
Conjugates (6), (6), (4), (4), (4), (4), (4), (4), (4), (4), (4), (2), (2), (1), (1)
Epitopes (53), (15), (12), (12), (4), (4), (4), (4), (4), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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