Ataxia Telangiectasia Mutated (ATM) antibody

Antigen: Ataxia Telangiectasia Mutated (ATM)

Synonyms: AT1, ATA, ATC, ATD, ATE, ATDC, TEL1, TELO1, MGC74674, DKFZp781A0353, AI256621, C030026E19Rik, ATM, Tefu, atm/tefu, dATM, tef, DmelCG6535, CG6535, Xatm

Clonality: Monoclonal

Host: Rabbit

Reactivity: Human

Conjugate: Un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP)

Certificates: ISO 9001:2008

Catalog no.: ABIN649330

Additional Information

Alternative name: ATM

Gene ID: 472

UniProt: Q13315

Description: Other names: ATM, Serine-protein kinase ATM, Ataxia telangiectasia mutated

Characteristics: Rabbit Monoclonal Antibody

Specificity: A synthetic peptide corresponding to residues surrounding Serine 1981 of human ATM was used as immunogen.

Molecular Weight: 370 kDA

Comments:

Background: ATM is a nuclear phosphoprotein involved in Ataxia-telangiectasia (A-T) an autosomal recessive disorder characterized by cerebellar ataxia, immune deficiencies, increased cancer predisposition, chromosomal instability and radiation sensitivity (1-2). This large protein (370 kDa) is involved in genome stability, cellular responses to DNA damage and cell cycle control. More than 100 mutations have been identified so far and are expected to inactivate the ATM protein by truncation or large deletions (3). Defects in ATM contribute to various B cell and T cell Leukemia (4).

Application Details

Application Notes: The suggested dilution is: WB: ~~ 1:1000~10000 IP: ~~ 1:50 ICC: ~~ 1:100~250 IHC: ~~ 1:100~250

Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Storage: ATM Antibody can be stored at -20°C for up to 12 months from time of receipt.

Research Area: Signaling, Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cancer, Transcription Factors, Chromatin, Neurology, Cell Structure

Restrictions: For Research Use only

Publications

Product: Harnden: "The nature of ataxia-telangiectasia: problems and perspectives." in: International journal of radiation biology, Vol. 66, Issue 6 Suppl, pp. S13-9, 1995 (PubMed).

McConville, Byrd, Ambrose et al.: "Paired STSs amplified from radiation hybrids, and from associated YACs, identify highly polymorphic loci flanking the ataxia telangiectasia locus on chromosome 11q22-23." in: Human molecular genetics, Vol. 2, Issue 7, pp. 969-74, 1993 (PubMed).

Westphal, Schmaltz, Rowan et al.: "Genetic interactions between atm and p53 influence cellular proliferation and irradiation-induced cell cycle checkpoints." in: Cancer research, Vol. 57, Issue 9, pp. 1664-7, 1997 (PubMed).