anti-Aurora A antibody (Aurora Kinase A) (C-Term)

Details for Product anti-AURKA Antibody No. ABIN649335
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Antigen
Epitope
C-Term
(44), (36), (26), (15), (4), (4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(210), (66), (39), (10), (5), (3), (2), (1), (1), (1), (1), (1)
Host
Rabbit
(158), (57), (21)
Clonality
Monoclonal
Conjugate
This Aurora A antibody is un-conjugated
(12), (6), (6), (5), (5), (5), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(179), (80), (71), (47), (36), (31), (17), (12), (10), (6), (5), (4), (2), (1), (1)
Pubmed 1 reference available
Quantity 100 μL
Options
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Request Want additional data for this product?

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Specificity A synthetic peptide corresponding to residues near the C-terminus of human Aurora-A was used as an immunogen.
Alternative Name Aurora-A (AURKA Antibody Abstract)
Background Aurora-A is a member of a novel family of serine/threonine kinases that have been identified as key regulators of the mitotic cell division process (1). Aurora-A is ubiquitously expressed and activated through an interaction with Ajuba and TPX2 during late G2 and mitotic phases. Activated form regulates the functions of centrosomes, spindles, and kinetochores required for normal mitotic progression. Initially localized at centrosome during interphase, Aurora-A is translocated to mitotic spindles in early mitotic phase and finally degraded after metaphaseanaphase transition (2). Overexpression of Aurora-A is seen various tumors, where an overexpression can induce abnormalities in G2 and Spindle checkpoints, and cytokinesis failure (3).
Synonyms: AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6, Serine/threonine-protein kinase 6, Breast tumor-amplified kinase
Molecular Weight 46 kDA
Gene ID 6790
UniProt O14965
Research Area Ubiquitin-related antibodies, Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cancer, Cell Cycle, Chromatin, Signaling, Cell Structure
Application Notes IHC: = 1:100-250, WB: = 1:1000-10000
Comment

Background: Aurora-A is a member of a novel family of serine/threonine kinases that have been identified as key regulators of the mitotic cell division process (1). Aurora-A is ubiquitously expressed and activated through an interaction with Ajuba and TPX2 during late G2 and mitotic phases. Activated form regulates the functions of centrosomes, spindles, and kinetochores required for normal mitotic progression. Initially localized at centrosome during interphase, Aurora-A is translocated to mitotic spindles in early mitotic phase and finally degraded after metaphaseanaphase transition (2). Overexpression of Aurora-A is seen various tumors, where an overexpression can induce abnormalities in G2 and Spindle checkpoints, and cytokinesis failure (3).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Aurora-A Antibody (C-term) can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Katayama, Brinkley, Sen: "The Aurora kinases: role in cell transformation and tumorigenesis." in: Cancer metastasis reviews, Vol. 22, Issue 4, pp. 451-64, 2003 (PubMed).

Validation Images
Catalog No. ABIN649335
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