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Aurora Kinase A (AURKA) (C-Term) antibody

Antigen

Aurora Kinase A (AURKA)
Synonyms
AIK, ARK1, AURA, BTAK, STK6, STK7, STK15, AURORA2, MGC34538, IAK, Ark1, Ayk1, Stk6, AIRK1, AU019385, AW539821, Aurora-A, 87A7-9/2, AurA, ck10, ck[10], l(3)87Ac, l(3)ck10, DmelCG3068, CG3068, MGC124935 ... show more
Binding Site
Alternatives

C-Term
Clonality Monoclonal
Host
Alternatives

Rabbit
Reactivity
Alternatives

Human
Conjugate
Alternatives Un-conjugated
Application
Alternatives Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)
1 reference available
Certificates ISO 9001:2008
Catalog no. ABIN649335
Quantity 100ul  (Variants)
Price 450.00 $   Plus shipping costs $45.00
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Additional Information
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Alternative name Aurora-A
Gene ID 6790
UniProt O14965
Description Other names: AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6, Serine/threonine-protein kinase 6, Breast tumor-amplified kinase
Characteristics Rabbit Monoclonal Antibody
Specificity A synthetic peptide corresponding to residues near the C-terminus of human Aurora-A was used as an immunogen.
Molecular Weight 46 kDA
Comments

Background: Aurora-A is a member of a novel family of serine/threonine kinases that have been identified as key regulators of the mitotic cell division process (1). Aurora-A is ubiquitously expressed and activated through an interaction with Ajuba and TPX2 during late G2 and mitotic phases. Activated form regulates the functions of centrosomes, spindles, and kinetochores required for normal mitotic progression. Initially localized at centrosome during interphase, Aurora-A is translocated to mitotic spindles in early mitotic phase and finally degraded after metaphaseanaphase transition (2). Overexpression of Aurora-A is seen various tumors, where an overexpression can induce abnormalities in G2 and Spindle checkpoints, and cytokinesis failure (3).
Synonyms AIK, ARK1, AURA, BTAK, STK6, STK7, STK15, AURORA2, MGC34538, IAK, Ark1, Ayk1, Stk6, AIRK1, AU019385, AW539821, Aurora-A, 87A7-9/2, AurA, ck10, ck[10], l(3)87Ac, l(3)ck10, DmelCG3068, CG3068, MGC124935, aurka, AURKA, MGC134472, aik, ark1, aura, btak, stk6, stk7, stk15, aurora2, zgc:100912

Application Details
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Application Notes The suggested dilution is: WB: ~~ 1:1000~10000 IP: ~~ 1:50 IHC: ~~ 1:100~250
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Storage Aurora-A Antibody (C-term) can be stored at -20°C for up to 12 months from time of receipt.
Research Area Ubiquitin-related antibodies, Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cancer, Cell Cycle, Chromatin, Signaling, Cell Structure
Restrictions For Research Use only

Publications
Application Details Alternatives Variants back to top

Product Katayama, Brinkley, Sen: "The Aurora kinases: role in cell transformation and tumorigenesis." in: Cancer metastasis reviews, Vol. 22, Issue 4, pp. 451-64, 2003 (PubMed).

Alternatives
Application Details Publications Variants back to top

Alternatives for antigen "Aurora Kinase A (AURKA)", type "Antibodies"
Hosts Rabbit (86), Mouse (25), Goat (9), Sheep (1)
Reactivities Human (113), Mouse (Murine) (31), Rat (Rattus) (31), Cow (Bovine) (21), Horse (Equine) (18), Pig (Porcine) (18), Dog (Canine) (7), Monkey (7), Sheep (Ovine) (5), Cat (Feline) (1), Chicken (1)
Applications Western Blotting (WB) (91), ELISA (57), Immunofluorescence (IF) (43), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (27), Immunohistochemistry (IHC) (22), Immunoprecipitation (IP) (20), Flow Cytometry (FACS) (7), Immunohistochemistry (Fixed) (IHC (fx)) (4), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Immunocytochemistry (ICC) (2), Immunoelectron Microscopy (IEM) (1), Immunohistochemistry (Frozen Sections) (IHC (fro)) (1)
Conjugates Biotin (5), Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1)
Epitopes N-Term (15), pThr288 (14), C-Term (12), AA 100-150 (1), Internal Region (1), N-Term,Glu107 (1), N-Term,Ser89 (1), pSer241 (1), pThr198,pThr232 (1)