Aurora Kinase B (AURKB) (N-Term) antibody

Details for Product No. ABIN649336
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Antigen
Synonyms
Aur B, AurB, Aurora B, Aurora-B, CG6620, DmAIRK2, DmAurB, DmAuroraB, Dmel\\CG6620, IAL, IAL1, Ial, aurB, aurora B, XAIRK2, aik2, aim-1, aim1, airk2, ark2, ipl1, stk12, stk5, aurkb, AIK2, AIM-1, AIM1,  ... show more
Aur B, AurB, Aurora B, Aurora-B, CG6620, DmAIRK2, DmAurB, DmAuroraB, Dmel\\CG6620, IAL, IAL1, Ial, aurB, aurora B, XAIRK2, aik2, aim-1, aim1, airk2, ark2, ipl1, stk12, stk5, aurkb, AIK2, AIM-1, AIM1, ARK2, IPL1, PPP1R48, STK12, STK5, aurkb-sv1, aurkb-sv2, AIRK2, AL022959, Aik2, Aim1, Ark2, STK-1, Stk12, Stk5, ARK-2, CHUNP6896, fa09g06, stka, wu:fa09g06, IKK2 show less
Epitope
N-Term
(21), (20), (19), (12), (7), (7), (6), (6), (4), (4), (4), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(159), (71), (64), (15), (14), (3), (2), (1), (1), (1)
Host
Rabbit
(128), (31), (5), (1)
Clonality
Monoclonal
Conjugate
Un-conjugated
(5), (5), (5), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(128), (99), (55), (45), (29), (20), (18), (8), (1)
Pubmed 2 references available
Quantity 100 μL
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Catalog No. ABIN649336
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Specificity A synthetic peptide corresponding to residues near the N-terminus of human Aurora-B was used as an immunogen.
Alternative Name Aurora-B
Background Aurora-B is a member of a novel family of serine/threonine kinases that have been identified as key regulators of the mitotic cell division process. Aurora-B is known to be involved in the regulation of centrosome function, bipolar spindle assembly and chromosome segregation. Aurora kinases are localized at the centrosomes of interphase cells, at the poles of the bipolar spindle and in the midbody of the mitotic apparatus. Substrates identified for the Aurora-B kinases include a kinesin-like motor protein, spindle apparatus proteins, histone H3 protein, kinetochore protein and the tumor suppressor protein p53 (1). Overexpression of aurora B produced multinuclearity and induced aggressive metastasis, suggesting that overexpressed aurora B has multiple functions in cancer development. Identification of Aurora kinases as RasGAP Src homology 3 domain binding protein, also implicates these kinases as potential effectors in the Ras pathway relevant to oncogenesis (2).
Synonyms: AURKB, AIK2, AIM1, ARK2, STK12, Serine/threonine-protein kinase 12, STK-1
Molecular Weight 39 kDA
Gene ID 9212
UniProt Q96GD4
Research Area Signaling, Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Cycle, Chromatin, Cell Structure
Application Notes IHC: = 1:250-500, WB: = 1:1000-5000
Comment

Background: Aurora-B is a member of a novel family of serine/threonine kinases that have been identified as key regulators of the mitotic cell division process. Aurora-B is known to be involved in the regulation of centrosome function, bipolar spindle assembly and chromosome segregation. Aurora kinases are localized at the centrosomes of interphase cells, at the poles of the bipolar spindle and in the midbody of the mitotic apparatus. Substrates identified for the Aurora-B kinases include a kinesin-like motor protein, spindle apparatus proteins, histone H3 protein, kinetochore protein and the tumor suppressor protein p53 (1). Overexpression of aurora B produced multinuclearity and induced aggressive metastasis, suggesting that overexpressed aurora B has multiple functions in cancer development. Identification of Aurora kinases as RasGAP Src homology 3 domain binding protein, also implicates these kinases as potential effectors in the Ras pathway relevant to oncogenesis (2).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Aurora-B Antibody (N-term) can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Wheatley, Grynszpan: "Can we speed up the online publishing process? And who will pay for it, anyway?" in: Cancer cell international, Vol. 2, Issue 1, pp. 5, 2002 (PubMed).

Katayama, Brinkley, Sen: "The Aurora kinases: role in cell transformation and tumorigenesis." in: Cancer metastasis reviews, Vol. 22, Issue 4, pp. 451-64, 2003 (PubMed).

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