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CD86 Molecule (CD86) antibody

Details for Product No. ABIN649339
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Antigen
Synonyms B7-2, B7, B7.2, B70, CLS1, Cd28l2, ETC-1, Ly-58, Ly58, MB7, MB7-2, TS/A-2, CD28LG2, LAB72
Reactivity
Human, Rat (Rattus)
(227), (162), (68), (21), (18), (17), (8), (1)
Host
Rabbit
(201), (170), (53), (1)
Clonality
Monoclonal
Conjugate
Un-conjugated
(66), (51), (44), (18), (14), (7), (7), (6), (4), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(338), (83), (67), (58), (48), (39), (35), (14), (11), (6), (3), (3), (2), (2), (1)
Pubmed 2 references available
Quantity 100 µL
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Catalog No. ABIN649339
450.00 $
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Specificity A synthetic peptide corresponding to residues near the N-terminus of human B7-2 was used as an immunogen.
Alternative Name CD86
Background B7-2 (CD86) is an important costimulatory molecule for the priming and activation of naive and memory T cells, respectively. Soluble CD86 is produced by resting monocytes and results from an alternatively spliced transcript (CD86deltaTM) characterized by deletion of the transmembrane domain (1). Engagement of CD28 with B7-1 and B7-2 ligands on antigen-presenting cells (APCs) provides a stimulatory signal for T-cell activation, whereas subsequent engagement of CTLA-4 with these same ligands results in attenuation of the response. Given their central function in immune modulation, CTLA-4- and CD28-associated signaling pathways are primary therapeutic targets for preventing autoimmune disease, graft versus host disease, graft rejection and promoting tumor immunity (2). It has also been shown that on B cells and macrophages, heat shock proteins GroES and GroEL both stimulated the expression of B7-2 (3)
Synonyms: CD86, CD28LG2, T-lymphocyte activation antigen CD86, Activation B7-2 antigen,CTLA-4 counter-receptor B7.2,B70,FUN-1,BU63
Molecular Weight 70 kDA
Gene ID 942
UniProt P42081
Research Area Ubiquitin-related antibodies, Cell Signaling, Protein Modifications, Cell Structure
Application Notes IHC: = 1:100-250, WB: = 1:10000-50000
Comment

Background: B7-2 (CD86) is an important costimulatory molecule for the priming and activation of naive and memory T cells, respectively. Soluble CD86 is produced by resting monocytes and results from an alternatively spliced transcript (CD86deltaTM) characterized by deletion of the transmembrane domain (1). Engagement of CD28 with B7-1 and B7-2 ligands on antigen-presenting cells (APCs) provides a stimulatory signal for T-cell activation, whereas subsequent engagement of CTLA-4 with these same ligands results in attenuation of the response. Given their central function in immune modulation, CTLA-4- and CD28-associated signaling pathways are primary therapeutic targets for preventing autoimmune disease, graft versus host disease, graft rejection and promoting tumor immunity (2). It has also been shown that on B cells and macrophages, heat shock proteins GroES and GroEL both stimulated the expression of B7-2 (3)

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment B7-2/CD86 Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Jeannin, Magistrelli, Aubry et al.: "Soluble CD86 is a costimulatory molecule for human T lymphocytes." in: Immunity, Vol. 13, Issue 3, pp. 303-12, 2000 (PubMed).

Schwartz, Zhang, Fedorov et al.: "Structural basis for co-stimulation by the human CTLA-4/B7-2 complex." in: Nature, Vol. 410, Issue 6828, pp. 604-8, 2001 (PubMed).

Validation Images
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