Did you know that you can buy products from over 140 different suppliers from us?

V-Set Domain Containing T Cell Activation Inhibitor 1 (VTCN1) antibody

Details for Product No. ABIN649340
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Antigen
Synonyms B7-H4, B7H4, B7S1, B7X, B7h.5, PRO1291, VCTN1, B7h4, B7s1, B7x, BC032925, RGD1311204
Reactivity
Human, Rat (Rattus)
(68), (39), (15), (15), (2)
Host
Rabbit
(42), (20), (19), (8)
Clonality
Monoclonal
Conjugate
Un-conjugated
(12), (11), (8), (4), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(41), (38), (35), (13), (12), (10), (7), (6), (2), (2)
Pubmed 3 references available
Quantity 100 µL
Options
Shipping to United States (Change)
Availability Will be delivered in 2 to 3 Business Days
Catalog No. ABIN649340
450.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Specificity A peptide corresponding to residues near N-term of human GNB2 was used as an immunogen.
Alternative Name B7-H4
Background As a member of B7 family, B7-H4 (VTCN1) plays a critical role in the regulation of antigen-specific immune responses. B7-H4 is a co-stimulatory protein expressed in activated T cells and is involved in the negative regulation of cell-mediated immunity in peripheral tissues (1). B7-H4 ligation to its receptor BTLA T-lymphocytes results in inhibition of T-cell activation, cytokine secretion, and the development of cytotoxicity (2). B7-H4 protein is typically expressed on the surface of activated T-cells, B-cells, monocytes, and dendritic cells, but not in most normal tissues. In tissues, B7-H4 is over expressed in breast, endometrial, ovarian, renal cell (RCC), and non-small cell lung carcinomas (NSCLC). B7-H4 has been identified as an important cancer marker for breast and ovarian cancers (3).
Molecular Weight 50 kDA
Gene ID 79679
UniProt Q7Z7D3
Research Area Cell Signaling, Cell Structure, Protein Modifications
Application Notes IHC: = 1:250-500, WB: = 1:500
Comment

Background: As a member of B7 family, B7-H4 (VTCN1) plays a critical role in the regulation of antigen-specific immune responses. B7-H4 is a co-stimulatory protein expressed in activated T cells and is involved in the negative regulation of cell-mediated immunity in peripheral tissues (1). B7-H4 ligation to its receptor BTLA T-lymphocytes results in inhibition of T-cell activation, cytokine secretion, and the development of cytotoxicity (2). B7-H4 protein is typically expressed on the surface of activated T-cells, B-cells, monocytes, and dendritic cells, but not in most normal tissues. In tissues, B7-H4 is over expressed in breast, endometrial, ovarian, renal cell (RCC), and non-small cell lung carcinomas (NSCLC). B7-H4 has been identified as an important cancer marker for breast and ovarian cancers (3).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment B7-H4 Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Tringler, Zhuo, Pilkington et al.: "B7-h4 is highly expressed in ductal and lobular breast cancer." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 11, Issue 5, pp. 1842-8, 2005 (PubMed).

Simon, Zhuo, Corral et al.: "B7-h4 is a novel membrane-bound protein and a candidate serum and tissue biomarker for ovarian cancer." in: Cancer research, Vol. 66, Issue 3, pp. 1570-5, 2006 (PubMed).

"The universal protein resource (UniProt)." in: Nucleic acids research, Vol. 36, Issue Database issue, pp. D190-5, 2008 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN649340
450.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
Did you look for something else?
back to top