BCL2-Associated Agonist of Cell Death (BAD) (N-Term) antibody

Details for Product No. ABIN649341
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Antigen
Synonyms bad, fa01b12, wu:fa01b12, wu:fa96d04, BAD, BBC2, BCL2L8, AI325008, Bbc2
Epitope
N-Term
(41), (38), (32), (32), (22), (21), (21), (21), (18), (17), (16), (16), (15), (13), (12), (10), (10), (10), (10), (10), (10), (9), (9), (9), (9), (9), (9), (9), (9), (9), (9), (8), (8), (8), (8), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (5), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Rat (Rattus)
(516), (307), (216), (24), (14), (14), (7), (4)
Host
Rabbit
(628), (31), (3)
Clonality
Monoclonal
Conjugate
Un-conjugated
(37), (37), (37), (30), (30), (30), (7), (7), (7), (7), (7), (7), (7), (7)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(351), (303), (243), (218), (71), (70), (27), (18), (8), (8), (2), (2), (2), (2)
Pubmed 2 references available
Quantity 100 μL
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Catalog No. ABIN649341
450.00 $
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Specificity A synthetic peptide corresponding to residues in the N-term of human Bad was used as immunogen. The antibody does not cross-react with other Bcl-2 members.
Alternative Name Bad
Background Bad is a pro-apoptotic member of the Bcl-2 family. Bad will bind preferentially Bcl-xL over Bcl-2 through its partial (9-16 a.a) BH3 domain. Additionally, Bad can reverse the death repressor activity of Bcl-xL but not of Bcl-2. Upon dephosphorylation, activated Bad translocates to the mitochondria and displace Bcl-2 from tBid sequestration to initiate mitochondrial dysfunction. The switching on/off of its phosphorylation by growth/survival factors regulates Bad activity.
Synonyms: BAD, BBC6, BCL2L8, Bcl2 antagonist of cell death, Bcl-XL/Bcl-2-associated death promoter
Molecular Weight 23 kDA
Gene ID 572
UniProt Q92934
Research Area Apoptosis/Necrosis, Signaling, Phospho-specific antibodies, Protein Modifications, Cell Structure
Application Notes IHC: = 1:100-250, WB: = 1:10000
Comment

Background: Bad is a pro-apoptotic member of the Bcl-2 family. Bad will bind preferentially Bcl-xL over Bcl-2 through its partial (9-16 a.a) BH3 domain. Additionally, Bad can reverse the death repressor activity of Bcl-xL but not of Bcl-2. Upon dephosphorylation, activated Bad translocates to the mitochondria and displace Bcl-2 from tBid sequestration to initiate mitochondrial dysfunction. The switching on/off of its phosphorylation by growth/survival factors regulates Bad activity.

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Bad Antibody (N-term) can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Feng, Funk, Wang et al.: "The RNA component of human telomerase." in: Science (New York, N.Y.), Vol. 269, Issue 5228, pp. 1236-41, 1995 (PubMed).

Greider: "Telomere length regulation." in: Annual review of biochemistry, Vol. 65, pp. 337-65, 1996 (PubMed).

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