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Details for Product No. ABIN649341

BCL2-Associated Agonist of Cell Death (BAD) (N-Term) antibody

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Antigen
Synonyms BBC2, BCL2L8, Bbc2, AI325008, bad, fa01b12, wu:fa01b12, wu:fa96d04, BAD
Epitope
»Alternatives N-Term
Reactivity
»Alternatives Human, Rat (Rattus)
Host
»Alternatives Rabbit
Clonality Monoclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP), Flow Cytometry (FACS)
Pubmed 2 references available
Catalog no. ABIN649341
Quantity 100 µL
Price
450.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Specificity A synthetic peptide corresponding to residues in the N-term of human Bad was used as immunogen. The antibody does not cross-react with other Bcl-2 members.
Alternative Name Bad
Background Bad is a pro-apoptotic member of the Bcl-2 family. Bad will bind preferentially Bcl-xL over Bcl-2 through its partial (9-16 a.a) BH3 domain. Additionally, Bad can reverse the death repressor activity of Bcl-xL but not of Bcl-2. Upon dephosphorylation, activated Bad translocates to the mitochondria and displace Bcl-2 from tBid sequestration to initiate mitochondrial dysfunction. The switching on/off of its phosphorylation by growth/survival factors regulates Bad activity.
Synonyms: BAD, BBC6, BCL2L8, Bcl2 antagonist of cell death, Bcl-XL/Bcl-2-associated death promoter
Molecular Weight 23 kDA
Gene ID 572
UniProt Q92934
Research Area Apoptosis/Necrosis, Signaling, Phospho-specific antibodies, Protein Modifications, Cell Structure
Application Notes The suggested dilution is: WB: ~~ 1:10000 IP: ~~ 1:50 FC: ~~ 1:50 ICC: ~~ 1:250~500 IHC: ~~ 1:100~250
Comment

Background: Bad is a pro-apoptotic member of the Bcl-2 family. Bad will bind preferentially Bcl-xL over Bcl-2 through its partial (9-16 a.a) BH3 domain. Additionally, Bad can reverse the death repressor activity of Bcl-xL but not of Bcl-2. Upon dephosphorylation, activated Bad translocates to the mitochondria and displace Bcl-2 from tBid sequestration to initiate mitochondrial dysfunction. The switching on/off of its phosphorylation by growth/survival factors regulates Bad activity.

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Storage -20 °C
Storage Comment Bad Antibody (N-term) can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Feng, Funk, Wang et al.: "The RNA component of human telomerase." in: Science (New York, N.Y.), Vol. 269, Issue 5228, pp. 1236-41, 1995 (PubMed).

Greider: "Telomere length regulation." in: Annual review of biochemistry, Vol. 65, pp. 337-65, 1996 (PubMed).

Alternatives for antigen "BCL2-Associated Agonist of Cell Death (BAD)", type "Antibodies"
Hosts (398), (23), (4), (2)
Reactivities (362), (258), (213), (60), (37), (37), (24), (3), (2), (2)
Applications (242), (128), (123), (110), (83), (60), (25), (10), (7), (5), (4), (3), (3), (2), (2), (2)
Conjugates (11), (11), (11), (11), (11), (11), (11), (11), (11), (11), (11)
Epitopes (37), (34), (27), (22), (21), (20), (20), (19), (15), (13), (7), (5), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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