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Details for Product No. ABIN649342

BCL2-Associated Athanogene (BAG1) antibody

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Antigen
Synonyms BAG-1, HAP, RAP46, Bag-1, ATBAG1, BCL-2-associated athanogene 1, MSG15.15, MSG15_15
Reactivity
»Alternatives Human, Rat (Rattus)
Host
»Alternatives Rabbit
Clonality Monoclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP)
Pubmed 3 references available
Catalog no. ABIN649342
Quantity 100 µL
Price
450.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Specificity A synthetic peptide corresponding to residues following the repeat 7 of human Bag-1 was used as immunogen. The antibody should recognize all three isoforms of Bag-1 (Bag-1L, Bag-1M and Bag-1S).
Alternative Name Bag-1
Background Members of the Bcl-2 family of proteins play varied stimulatory or inhibitory roles in the regulation of programmed cell death, or apoptosis. One member of this family, Bcl2-Interacting Protein-1 (BAG-1), functions in conjunction with Bcl-2 to inhibit apoptosis (1,2). BAG-1 is a heat shock 70 kDa (Hsp70)- binding protein (3) that is localized to either the cytosol, nucleus or both.
Synonyms: BAG1, HAP, BAG family molecular chaperone regulator 1, Bcl-2-associated athanogene 1,Glucocorticoid receptor-associated protein RAP46
Molecular Weight 33 / 46 / 50 kDA
UniProt Q99933
Research Area Ubiquitin-related antibodies, Apoptosis/Necrosis, Protein Modifications, Cell Structure
Application Notes The suggested dilution is: WB: ~~ 1:1000~10000 ICC: ~~ 1:100~250 IHC: ~~ 1:100~250
Comment

Background: Members of the Bcl-2 family of proteins play varied stimulatory or inhibitory roles in the regulation of programmed cell death, or apoptosis. One member of this family, Bcl2-Interacting Protein-1 (BAG-1), functions in conjunction with Bcl-2 to inhibit apoptosis (1,2). BAG-1 is a heat shock 70 kDa (Hsp70)- binding protein (3) that is localized to either the cytosol, nucleus or both.

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Storage -20 °C
Storage Comment Bag-1 Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Takayama, Kochel, Irie et al.: "Cloning of cDNAs encoding the human BAG1 protein and localization of the human BAG1 gene to chromosome 9p12." in: Genomics, Vol. 35, Issue 3, pp. 494-8, 1996 (PubMed).

Matsuzawa, Takayama, Froesch et al.: "p53-inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth: suppression by BAG-1." in: The EMBO journal, Vol. 17, Issue 10, pp. 2736-47, 1998 (PubMed).

Takayama, Xie, Reed: "An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators." in: The Journal of biological chemistry, Vol. 274, Issue 2, pp. 781-6, 1999 (PubMed).

Alternatives for antigen "BCL2-Associated Athanogene (BAG1)", type "Antibodies"
Hosts (79), (16)
Reactivities (81), (54), (42), (13), (2), (1)
Applications (82), (41), (26), (18), (16), (14), (10), (8), (6), (3), (2), (2), (2), (2)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (18), (16), (4), (2), (2), (2), (2), (1), (1), (1), (1)
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