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BCL2-Associated Athanogene (BAG1) antibody

Details for Product No. ABIN649342
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Antigen
Synonyms BAG-1, HAP, RAP46, Bag-1, ATBAG1, BCL-2-associated athanogene 1, MSG15.15, MSG15_15
Reactivity
Human, Rat (Rattus)
(78), (52), (39), (12), (1), (1)
Host
Rabbit
(74), (15)
Clonality
Monoclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
(76), (32), (29), (15), (12), (10), (10), (7), (2), (2), (2), (2), (1)
Pubmed 3 references available
Quantity 100 µL
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Availability Will be delivered in 2 to 3 Business Days
Catalog No. ABIN649342
450.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Specificity A synthetic peptide corresponding to residues following the repeat 7 of human Bag-1 was used as immunogen. The antibody should recognize all three isoforms of Bag-1 (Bag-1L, Bag-1M and Bag-1S).
Alternative Name Bag-1
Background Members of the Bcl-2 family of proteins play varied stimulatory or inhibitory roles in the regulation of programmed cell death, or apoptosis. One member of this family, Bcl2-Interacting Protein-1 (BAG-1), functions in conjunction with Bcl-2 to inhibit apoptosis (1,2). BAG-1 is a heat shock 70 kDa (Hsp70)- binding protein (3) that is localized to either the cytosol, nucleus or both.
Synonyms: BAG1, HAP, BAG family molecular chaperone regulator 1, Bcl-2-associated athanogene 1,Glucocorticoid receptor-associated protein RAP46
Molecular Weight 33 / 46 / 50 kDA
UniProt Q99933
Research Area Ubiquitin-related antibodies, Apoptosis/Necrosis, Protein Modifications, Cell Structure
Application Notes The suggested dilution is: WB: = 1:1000-10000 , IHC: = 1:100-250
Comment

Background: Members of the Bcl-2 family of proteins play varied stimulatory or inhibitory roles in the regulation of programmed cell death, or apoptosis. One member of this family, Bcl2-Interacting Protein-1 (BAG-1), functions in conjunction with Bcl-2 to inhibit apoptosis (1,2). BAG-1 is a heat shock 70 kDa (Hsp70)- binding protein (3) that is localized to either the cytosol, nucleus or both.

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Bag-1 Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Takayama, Kochel, Irie et al.: "Cloning of cDNAs encoding the human BAG1 protein and localization of the human BAG1 gene to chromosome 9p12." in: Genomics, Vol. 35, Issue 3, pp. 494-8, 1996 (PubMed).

Matsuzawa, Takayama, Froesch et al.: "p53-inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth: suppression by BAG-1." in: The EMBO journal, Vol. 17, Issue 10, pp. 2736-47, 1998 (PubMed).

Takayama, Xie, Reed: "An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators." in: The Journal of biological chemistry, Vol. 274, Issue 2, pp. 781-6, 1999 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN649342
450.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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