BCL2-Associated Athanogene 2 (BAG2) antibody

Details for Product No. ABIN649344
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Antigen
Synonyms BAG-2, dJ417I1.2, 2610042A13Rik, BC016230, zgc:64195, ATBAG2, BCL-2-associated athanogene 2, MTG10.13, MTG10_13, bag2, MGC89300, BAG2
Reactivity
Human
(32), (16), (15), (13), (13), (12), (1), (1), (1), (1)
Host
Rabbit
(27), (5), (4)
Clonality
Monoclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(23), (10), (10), (6), (5), (4), (2), (2), (2), (1)
Pubmed 1 reference available
Catalog no. ABIN649344
Quantity 100 µL
Price
450.00 $   Plus shipping costs $45.00
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Specificity A synthetic peptide corresponding to residues in the N-terminus of human Bag-2 was used as immunogen.
Alternative Name Bag-2
Background BAG-2 is a member of a family of BAG-related proteins (BAG-2, BAG-3, BAG-4, BAG-5). BAG-family proteins may play a role in providing opportunities for specification and diversification of Heat Shock Protein (Hsp70) chaperone functions. Hsp70 family molecular chaperones play critical roles in protein folding and trafficking in all eukaryotic cells. BAG-1 binds the ATPase domains of Hsp70 and Hsc70, modulating their chaperone activity and functioning as a competitive antagonist of the co-chaperone Hip. BAG-2 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner (1).
Synonyms: BAG2, BAG family molecular chaperone regulator 2, Bcl-2-associated athanogene 2
Molecular Weight 23 kDA
Gene ID 9532
UniProt O95816
Research Area Signaling, Phospho-specific antibodies, Protein Modifications, Cell Structure
Application Notes IHC: = 1:100, WB: = 1:20000-200000
Comment

Background: BAG-2 is a member of a family of BAG-related proteins (BAG-2, BAG-3, BAG-4, BAG-5). BAG-family proteins may play a role in providing opportunities for specification and diversification of Heat Shock Protein (Hsp70) chaperone functions. Hsp70 family molecular chaperones play critical roles in protein folding and trafficking in all eukaryotic cells. BAG-1 binds the ATPase domains of Hsp70 and Hsc70, modulating their chaperone activity and functioning as a competitive antagonist of the co-chaperone Hip. BAG-2 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner (1).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Storage -20 °C
Storage Comment Bag-2 Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Takayama, Xie, Reed: "An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators." in: The Journal of biological chemistry, Vol. 274, Issue 2, pp. 781-6, 1999 (PubMed).

Hosts (27), (5), (4)
Reactivities (32), (16), (15), (13), (13), (12), (1), (1), (1), (1)
Applications (23), (10), (10), (6), (5), (4), (2), (2), (2), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (7), (2), (2), (2), (1), (1), (1)
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