BCL2-Antagonist/killer 1 (BAK1) antibody

Details for Product No. ABIN649347
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Antigen
Synonyms
ATBAK1, ATSERK3, BRI1-associated receptor kinase, ELG, ELONGATED, F17M5.190, F17M5_190, RECEPTOR KINASES LIKE SERK 10, RKS10, SERK3, SOMATIC EMBRYOGENESIS RECEPTOR-LIKE KINASE 3, Bak1, BAK, BAK-LIKE,  ... show more
ATBAK1, ATSERK3, BRI1-associated receptor kinase, ELG, ELONGATED, F17M5.190, F17M5_190, RECEPTOR KINASES LIKE SERK 10, RKS10, SERK3, SOMATIC EMBRYOGENESIS RECEPTOR-LIKE KINASE 3, Bak1, BAK, BAK-LIKE, BCL2L7, CDN1, Bak, N-BAK1, N-Bak show less
Reactivity
Human
(127), (52), (23), (5), (3), (2), (1), (1)
Host
Rabbit
(104), (15), (9), (1)
Clonality
Monoclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(101), (39), (36), (29), (17), (13), (10), (9), (9), (6), (4), (2), (2), (1)
Pubmed 3 references available
Quantity 100 μL
Options
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Catalog No. ABIN649347
450.00 $
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Specificity A synthetic peptide corresponding to residues near the N-term of human Bak was used as immunogen. The antibody does not cross-react with other Bcl-2 members.
Alternative Name Bak
Background Bak a pro-apoptotic analog to Bax, is a member of the Bcl-2 family of proteins. During mitochondria-regulated programmed cell death, Bak promotes apoptosis by binding Bcl-2 and inhibiting its anti-apoptotic function (1). Upon apoptotic stimulation, Bak translocates from the cytosol to the mitochondrial membrane (2). Pro-apoptotic cascade activates BID, which oligomerizes Bak into pores that result in the release of cytochrome c (2, 3). In healthy cells, Bak associate with Bcl-xL and Mcl-1 but not with Bcl-2, Bcl-w or A1 and only when freed of both Bak will induce apoptosis.
Synonyms: BAK1, BAK, BCL2L7, CDN1, Bcl-2 homologous antagonist/killer, Apoptosis regulator BAK,Bcl-2-like protein 7
Molecular Weight 23 kDA
Gene ID 578
UniProt Q16611
Research Area Apoptosis/Necrosis, Cell Structure
Application Notes IHC: = 1:250-500, WB: = 1:5000-10000
Comment

Background: Bak a pro-apoptotic analog to Bax, is a member of the Bcl-2 family of proteins. During mitochondria-regulated programmed cell death, Bak promotes apoptosis by binding Bcl-2 and inhibiting its anti-apoptotic function (1). Upon apoptotic stimulation, Bak translocates from the cytosol to the mitochondrial membrane (2). Pro-apoptotic cascade activates BID, which oligomerizes Bak into pores that result in the release of cytochrome c (2, 3). In healthy cells, Bak associate with Bcl-xL and Mcl-1 but not with Bcl-2, Bcl-w or A1 and only when freed of both Bak will induce apoptosis.

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Bak Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Greider, Blackburn: "Identification of a specific telomere terminal transferase activity in Tetrahymena extracts." in: Cell, Vol. 43, Issue 2 Pt 1, pp. 405-13, 1986 (PubMed).

Feng, Funk, Wang et al.: "The RNA component of human telomerase." in: Science (New York, N.Y.), Vol. 269, Issue 5228, pp. 1236-41, 1995 (PubMed).

Greider: "Telomere length regulation." in: Annual review of biochemistry, Vol. 65, pp. 337-65, 1996 (PubMed).

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