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BCL2-Associated X Protein (BAX) antibody

Details for Product No. ABIN649348
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Antigen
Synonyms bax, fj16e01, wu:fc50b10, wu:fj16e01, bax-A, xBax, xlbax, BAX, BCL2L4, BAX-ALPHA
Reactivity
Human, Rat (Rattus)
(312), (149), (142), (51), (51), (49), (12), (4), (2), (2), (1)
Host
Rabbit
(234), (106), (6)
Clonality
Monoclonal
Conjugate
Un-conjugated
(13), (9), (8), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(238), (125), (79), (74), (68), (68), (40), (31), (12), (10), (2), (2), (2), (2), (2), (1)
Pubmed 3 references available
Quantity 100 µL
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Catalog No. ABIN649348
450.00 $
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Specificity A synthetic peptide corresponding to residues in the vicinity of the dimerization domain of human Bax was used as immunogen. The antibody should recognize cytoplasmic isoform beta, delta, and membrane isoform alpha of Bax. The antibody does not cross-react with other Bcl-2 family members. Predicted to cross-react with bovine based on sequence homology.
Alternative Name Bax
Background Bax is a pro-apoptotic member of the Bcl-2 family of proteins. During mitochondria-regulated programmed cell death, Bax promotes apoptosis by binding Bcl-2 and inhibiting its anti-apoptotic function (1). Upon apoptotic stimulation, Bax translocates from the cytosol to the mitochondrial membrane (2). Through interactions with mitochondrial membrane proteins, Bax increases the membrane',s permeability, leading to the release of cytochrome c from mitochondria and initiation of the apoptotic caspase cascade (2,3).
Synonyms: BAX, BCL2L4, Apoptosis regulator BAX, Bcl-2-like protein 4
Molecular Weight 21 kDA
Gene ID 581
UniProt Q07814
Research Area Apoptosis/Necrosis, Signaling, Protein Modifications, Cell Structure, Cancer
Application Notes IHC: = 1:250, WB: = 1:1000-10000
Comment

Background: Bax is a pro-apoptotic member of the Bcl-2 family of proteins. During mitochondria-regulated programmed cell death, Bax promotes apoptosis by binding Bcl-2 and inhibiting its anti-apoptotic function (1). Upon apoptotic stimulation, Bax translocates from the cytosol to the mitochondrial membrane (2). Through interactions with mitochondrial membrane proteins, Bax increases the membrane',s permeability, leading to the release of cytochrome c from mitochondria and initiation of the apoptotic caspase cascade (2,3).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Bax Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Oltvai, Milliman, Korsmeyer: "Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death." in: Cell, Vol. 74, Issue 4, pp. 609-19, 1993 (PubMed).

Jürgensmeier, Xie, Deveraux et al.: "Bax directly induces release of cytochrome c from isolated mitochondria." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 9, pp. 4997-5002, 1998 (PubMed).

Narita, Shimizu, Ito et al.: "Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 25, pp. 14681-6, 1999 (PubMed).

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