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B-Cell CLL/lymphoma 10 (BCL10) (C-Term) antibody

Details for Product No. ABIN649350
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Antigen
Synonyms CLAP, mE10, CIPER, c-E10, CARMEN, ME10, cE10, BCL-10, C81403, AI132454, BCL10
Epitope
C-Term
(27), (16), (12), (8), (8), (3), (3), (2), (2), (1), (1), (1), (1)
Reactivity
Human
(168), (57), (47), (12), (12), (12), (1)
Host
Rabbit
(107), (60), (3)
Clonality
Monoclonal
Conjugate
Un-conjugated
(4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
(112), (65), (45), (34), (30), (21), (20), (18), (8), (4), (2), (1)
Pubmed 3 references available
Quantity 100 µL
Options
Shipping to United States (Change)
Availability Will be delivered in 2 to 3 Business Days
Catalog No. ABIN649350
450.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Specificity A synthetic peptide corresponding to residues in the C-term of human Bcl-10 was used as immunogen.
Alternative Name Bcl-10
Background Bcl-10 is an adaptor protein with a caspase recruitment domain (CARD) that promotes apoptosis and activates pro-caspase 9 and NF-kB (1-2). Bcl-10 also interacts with other CARD domain containing proteins including CARD9, 10, 11 and 14. Bcl-10 is found to form a complex with MALT1, a protein known to be translocated in MALT lymphomas. Bcl-10 and MALT1 play a critical role in antigen receptormediated lymphocyte proliferation and signaling to NF-B, which controls the expression of genes critical for cell survival, proliferation, and immune responses (3-4). Defects in Bcl-10 have been identified in various types of cancer.
Synonyms: BCL10, CIPER, CLAP, B-cell lymphoma/leukemia 10, CARD-like apoptotic protein
Molecular Weight 32 kDA
Gene ID 8915
UniProt O95999
Research Area Apoptosis/Necrosis, Signaling, Phospho-specific antibodies, Protein Modifications, Cell Structure, Cancer, Chromatin
Application Notes The suggested dilution is: WB: = 1:5000 , IHC: = 1:100-250
Comment

Background: Bcl-10 is an adaptor protein with a caspase recruitment domain (CARD) that promotes apoptosis and activates pro-caspase 9 and NF-kB (1-2). Bcl-10 also interacts with other CARD domain containing proteins including CARD9, 10, 11 and 14. Bcl-10 is found to form a complex with MALT1, a protein known to be translocated in MALT lymphomas. Bcl-10 and MALT1 play a critical role in antigen receptormediated lymphocyte proliferation and signaling to NF-B, which controls the expression of genes critical for cell survival, proliferation, and immune responses (3-4). Defects in Bcl-10 have been identified in various types of cancer.

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Bcl-10 Antibody (C-term) can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Wotherspoon, Pan, Diss et al.: "Cytogenetic study of B-cell lymphoma of mucosa-associated lymphoid tissue." in: Cancer genetics and cytogenetics, Vol. 58, Issue 1, pp. 35-8, 1992 (PubMed).

Ruland, Duncan, Elia et al.: "Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure." in: Cell, Vol. 104, Issue 1, pp. 33-42, 2001 (PubMed).

Ruefli-Brasse, French, Dixit: "Regulation of NF-kappaB-dependent lymphocyte activation and development by paracaspase." in: Science (New York, N.Y.), Vol. 302, Issue 5650, pp. 1581-4, 2003 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN649350
450.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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