|+1 404 474 4654|
|+1 888 205 9894 (TF)|
B-Cell CLL/lymphoma 10 (BCL10) (C-Term) antibody
|Synonyms||CLAP, mE10, CIPER, c-E10, CARMEN, ME10, cE10, BCL-10, C81403, AI132454, BCL10, MGC108338|
Alternatives Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP)
|3 references available|
|Price||450.00 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Description||Other names: BCL10, CIPER, CLAP, B-cell lymphoma/leukemia 10, CARD-like apoptotic protein|
|Characteristics||Rabbit Monoclonal Antibody|
|Specificity||A synthetic peptide corresponding to residues in the C-term of human Bcl-10 was used as immunogen.|
|Molecular Weight||32 kDA|
Background: Bcl-10 is an adaptor protein with a caspase recruitment domain (CARD) that promotes apoptosis and activates pro-caspase 9 and NF-kB (1-2). Bcl-10 also interacts with other CARD domain containing proteins including CARD9, 10, 11 and 14. Bcl-10 is found to form a complex with MALT1, a protein known to be translocated in MALT lymphomas. Bcl-10 and MALT1 play a critical role in antigen receptormediated lymphocyte proliferation and signaling to NF-B, which controls the expression of genes critical for cell survival, proliferation, and immune responses (3-4). Defects in Bcl-10 have been identified in various types of cancer.
|Application Notes||The suggested dilution is: WB: ~~ 1:5000 IP: ~~ 1:50 ICC: ~~ 1:100~250 IHC: ~~ 1:100~250|
|Buffer||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Bcl-10 Antibody (C-term) can be stored at -20°C for up to 12 months from time of receipt.|
|Research Area||Apoptosis/Necrosis, Signaling, Phospho-specific antibodies, Protein Modifications, Cell Structure, Cancer, Chromatin|
|Restrictions||For Research Use only|
Wotherspoon, Pan, Diss et al.: "Cytogenetic study of B-cell lymphoma of mucosa-associated lymphoid tissue." in: Cancer genetics and cytogenetics, Vol. 58, Issue 1, pp. 35-8, 1992 (PubMed).
Ruland, Duncan, Elia et al.: "Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure." in: Cell, Vol. 104, Issue 1, pp. 33-42, 2001 (PubMed).
Ruefli-Brasse, French, Dixit: "Regulation of NF-kappaB-dependent lymphocyte activation and development by paracaspase." in: Science (New York, N.Y.), Vol. 302, Issue 5650, pp. 1581-4, 2003 (PubMed).