BCL2-Like 1 (BCL2L1) antibody

Details for Product No. ABIN649354
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Antigen
Synonyms
BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS, Bcl(X)L, Bcl-XL, Bcl-Xs, Bcl2l, BclX, bcl-x, Bclx, bcl-X, Bcl-xl, Bcl-xL, BCL-XL, bcl-XL, bcl-x(l), bclxl, xR11, BCL2L1, bcl-xl/s,  ... show more
BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS, Bcl(X)L, Bcl-XL, Bcl-Xs, Bcl2l, BclX, bcl-x, Bclx, bcl-X, Bcl-xl, Bcl-xL, BCL-XL, bcl-XL, bcl-x(l), bclxl, xR11, BCL2L1, bcl-xl/s, bcl-xs, bcl2l, bclx, bcl-xl, Bcl-xS show less
Reactivity
Human, Rat (Rattus)
(275), (158), (134), (40), (40), (39), (12), (3), (3), (2), (1)
Host
Rabbit
(217), (82), (3), (2)
Clonality
Monoclonal
Conjugate
Un-conjugated
(13), (8), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (3), (2), (2), (2)
Application
Flow Cytometry (FACS), Immunohistochemistry (IHC), Western Blotting (WB)
(208), (97), (86), (70), (44), (40), (37), (34), (16), (14), (2), (2), (2), (1)
Pubmed 2 references available
Catalog no. ABIN649354
Quantity 100 µL
Price
450.00 $   Plus shipping costs $45.00
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Specificity A synthetic peptide corresponding to residues between BH3 and BH3 of Human Bcl-x was used as the immunogen. This antibody should recognize Bcl-xL, Bcl-xS and Bcl-x(beta) as the immunogen sequence is common to them. The antibody does not cross-react with other Bcl-2 family members.
Alternative Name Bcl-x
Background Bcl-x, a member of the Bcl-2 protein family, inhibits cell death, or apoptosis (1). Bcl-x is expressed as two isomeric forms, Bcl-xL and Bcl-xS, and is typically present in the cytosol in association with the mitochondrial membrane. Bcl-xL forms heterodimers with various proteins, including Bax, Bak and Bcl-2 (2). It has been found that eterodimerization with Bax does not seem to be required for anti-apoptotic activity (3). Since Bcl-xL can form an ion channel in synthetic lipid membranes, there is a strong possibility that this property plays a role in heterodimerization-independent cell survival (4). The Bcl-X(S) isoform promotes apoptosis.
Synonyms: BCL2L1, BCL2L, BCLX, Bcl-2-like protein 1, Apoptosis regulator Bcl-X
Molecular Weight 26 (Bcl-xL) / 19 (Bcl-xS) kDA
Gene ID 598
UniProt Q07817
Research Area Apoptosis/Necrosis, Cell Structure
Application Notes WB = 1:1000-10000, FACS = 1:50 ICC: = 1:100, IHC = 1:50-1:100
Comment

Background: Bcl-x, a member of the Bcl-2 protein family, inhibits cell death, or apoptosis (1). Bcl-x is expressed as two isomeric forms, Bcl-xL and Bcl-xS, and is typically present in the cytosol in association with the mitochondrial membrane. Bcl-xL forms heterodimers with various proteins, including Bax, Bak and Bcl-2 (2). It has been found that eterodimerization with Bax does not seem to be required for anti-apoptotic activity (3). Since Bcl-xL can form an ion channel in synthetic lipid membranes, there is a strong possibility that this property plays a role in heterodimerization-independent cell survival (4). The Bcl-X(S) isoform promotes apoptosis.

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Storage -20 °C
Storage Comment Bcl-x Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Sedlak, Oltvai, Yang et al.: "Multiple Bcl-2 family members demonstrate selective dimerizations with Bax." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 17, pp. 7834-8, 1995 (PubMed).

Cheng, Levine, Boise et al.: "Bax-independent inhibition of apoptosis by Bcl-XL." in: Nature, Vol. 379, Issue 6565, pp. 554-6, 1996 (PubMed).

Hosts (217), (82), (3), (2)
Reactivities (275), (158), (134), (40), (40), (39), (12), (3), (3), (2), (1)
Applications (208), (97), (86), (70), (44), (40), (37), (34), (16), (14), (2), (2), (2), (1)
Conjugates (13), (8), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (3), (2), (2), (2)
Epitopes (30), (20), (19), (17), (9), (9), (8), (6), (4), (4), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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