beta-2-Microglobulin (B2M) antibody

Details for Product No. ABIN649359
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Antigen
Synonyms Ly-m11, beta2m, beta2-m, bwm, wu:fa94c05, wu:fb10a09, b2m-W01, b2m-W03, b2m-Z01, b2m-Z02, b2m-Z03, B2M, b2m, B2MG
Reactivity
Human, Rat (Rattus)
(283), (37), (26), (10), (10), (4), (3), (2), (1), (1), (1), (1), (1)
Host
Rabbit
(162), (113), (28), (14), (10), (5), (2)
Clonality
Monoclonal
Conjugate
Un-conjugated
(24), (19), (15), (8), (4), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(172), (171), (98), (62), (46), (32), (28), (24), (22), (21), (12), (10), (10), (6), (4), (4), (4), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Pubmed 4 references available
Catalog no. ABIN649359
Quantity 100 µL
Price
450.00 $   Plus shipping costs $45.00
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Specificity A synthetic peptide corresponding to residues on the C-terminus of human beta-2-microglobulin was used as an immunogen.
Alternative Name Beta-2-Microglobulin
Background Beta-2-microglobulin (B2M) is a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells (1). It is a major component forming amyloid deposits in patients with hemodialysis-associated amyloidosis (HAA), a serious complication of long-term hemodialysis (2). B2M is found to contain two antiparallel beta-sheets, each of four beta-strands with the beta-sheets being connected by a single disulfide linkage. No evidence for any regular helical structure is found (3). B2M is an example of a low molecular weight serum protein, with a prominent beta-pleated sheet structure, that may adopt the fibrillar configuration of amyloid in certain pathologic states (4).
Synonyms: B2M, Beta-2-microglobulin form pI 5.3
Molecular Weight 13 kDA
Gene ID 567
UniProt P61769
Research Area Cell Signaling, Protein Modifications, Cell Structure
Application Notes The suggested dilution is: WB: = 1:1000-5000
Comment

Background: Beta-2-microglobulin (B2M) is a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells (1). It is a major component forming amyloid deposits in patients with hemodialysis-associated amyloidosis (HAA), a serious complication of long-term hemodialysis (2). B2M is found to contain two antiparallel beta-sheets, each of four beta-strands with the beta-sheets being connected by a single disulfide linkage. No evidence for any regular helical structure is found (3). B2M is an example of a low molecular weight serum protein, with a prominent beta-pleated sheet structure, that may adopt the fibrillar configuration of amyloid in certain pathologic states (4).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Storage -20 °C
Storage Comment Beta-2-Microglobulin Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Okon, Bray, Vucelić: "1H NMR assignments and secondary structure of human beta 2-microglobulin in solution." in: Biochemistry, Vol. 31, Issue 37, pp. 8906-15, 1992 (PubMed).

Güssow, Rein, Ginjaar et al.: "The human beta 2-microglobulin gene. Primary structure and definition of the transcriptional unit." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 139, Issue 9, pp. 3132-8, 1987 (PubMed).

Gorevic, Casey, Stone et al.: "Beta-2 microglobulin is an amyloidogenic protein in man." in: The Journal of clinical investigation, Vol. 76, Issue 6, pp. 2425-9, 1986 (PubMed).

Miyata, Inagi, Wada et al.: "Glycation of human beta 2-microglobulin in patients with hemodialysis-associated amyloidosis: identification of the glycated sites." in: Biochemistry, Vol. 33, Issue 40, pp. 12215-21, 1994 (PubMed).

Hosts (162), (113), (28), (14), (10), (5), (2)
Reactivities (283), (37), (26), (10), (10), (4), (3), (2), (1), (1), (1), (1), (1)
Applications (172), (171), (98), (62), (46), (32), (28), (24), (22), (21), (12), (10), (10), (6), (4), (4), (4), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Conjugates (24), (19), (15), (8), (4), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (12), (8), (7), (5), (4), (4), (3), (2), (2), (2), (2), (1), (1), (1), (1)
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