Arrestin, beta 1 (ARRB1) antibody

Details for Product No. ABIN649362
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Antigen
Synonyms arrb1, MGC83787, arb1, arr1, barr1, betaarr1, 1200006I17Rik, AW208571, G430100A01Rik, ARB1, ARR1, BARRES
Reactivity
Human, Rat (Rattus)
(83), (46), (43), (24), (12), (12), (12), (12), (2)
Host
Rabbit
(75), (9), (1)
Clonality
Monoclonal
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(65), (33), (21), (20), (16), (15), (11), (11), (4), (3), (1)
Pubmed 4 references available
Quantity 100 μL
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Catalog No. ABIN649362
450.00 $
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Specificity A synthetic peptide corresponding to residues near N-terminus of human -arrestin-1 was used as immunogen. Predicted to cross-react with bovine, based on sequence homology.
Alternative Name Beta-Arrestin-1
Background Beta-arrestin-1 is a member of the arrestin family that regulates beta-adrenergic receptor function. Beta-arrestins seem to mediate the desensitization and internalization of G protein-coupled receptors (1). -arrestin-1 is phosphorylated by Erk1/2 at Serine 412 of the C-terminus (2). Expanded roles for -arrestin-1 have been studied. Interaction with molecules such as clathrin, AP-2 and NSF directs the clathrin-mediated internalization of G-protein-coupled receptors. Interaction with molecules such as Src, Raf, Erk, ASK1 and JNK3 appears to regulate several pathways that result in the activation of MAP kinases (3,4).
Synonyms: ARRB1, ARR1, Beta-arrestin-1, Arrestin beta-1
Molecular Weight 50 kDA
Gene ID 408
UniProt P49407
Research Area Ubiquitin-related antibodies, Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure, Transcription Factors, Signaling
Application Notes IHC: = 1:100, WB: = 1:5000-20000
Comment

Background: Beta-arrestin-1 is a member of the arrestin family that regulates beta-adrenergic receptor function. Beta-arrestins seem to mediate the desensitization and internalization of G protein-coupled receptors (1). -arrestin-1 is phosphorylated by Erk1/2 at Serine 412 of the C-terminus (2). Expanded roles for -arrestin-1 have been studied. Interaction with molecules such as clathrin, AP-2 and NSF directs the clathrin-mediated internalization of G-protein-coupled receptors. Interaction with molecules such as Src, Raf, Erk, ASK1 and JNK3 appears to regulate several pathways that result in the activation of MAP kinases (3,4).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Beta-Arrestin-1 Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Lefkowitz: "G protein-coupled receptors. III. New roles for receptor kinases and beta-arrestins in receptor signaling and desensitization." in: The Journal of biological chemistry, Vol. 273, Issue 30, pp. 18677-80, 1998 (PubMed).

Lin, Daaka, Lefkowitz: "beta-arrestins regulate mitogenic signaling and clathrin-mediated endocytosis of the insulin-like growth factor I receptor." in: The Journal of biological chemistry, Vol. 273, Issue 48, pp. 31640-3, 1998 (PubMed).

Lin, Miller, Luttrell et al.: "Feedback regulation of beta-arrestin1 function by extracellular signal-regulated kinases." in: The Journal of biological chemistry, Vol. 274, Issue 23, pp. 15971-4, 1999 (PubMed).

Miller, Lefkowitz: "Expanding roles for beta-arrestins as scaffolds and adapters in GPCR signaling and trafficking." in: Current opinion in cell biology, Vol. 13, Issue 2, pp. 139-45, 2001 (PubMed).

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