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Background: Beta-catenin-like protein 1 (CTNNBL1) is an apoptosis inducing protein with a structural homology to beta-catenin and other armadillo family proteins. CTNNBL1 is highly conservered across various species and it is primarily expressed in the nucleus of various tissues (1). In human, CTNNBL1 shows highest expression in skeletal muscle, placenta, heart, spleen, testis, and thyroid tissues. In CHO cells, transient expression of CTNNBL1 cause it to localized to nucleus and induce apoptosis, with apoptosis inducing activity specific to its carboxy-terminal region (1). CTNNBL1 has been linked to possible role in Wnt/beta-catenin-signaling pathway and might have similar function as a beta catenin. CTNNBL1 may play an important role in the development of human obesity (2).