BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) antibody

Details for Product No. ABIN649376
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Antigen
Synonyms BAM, BIM, BOD, Bim, Bod, 1500006F24Rik, BimL, bim
Reactivity
Human
(171), (131), (112), (36), (36), (24), (1)
Host
Rabbit
(153), (17), (8), (7), (3)
Clonality
Monoclonal
Conjugate
Un-conjugated
(5), (5), (4), (4), (4), (4), (4), (4), (4), (4), (4)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(127), (63), (53), (40), (35), (34), (16), (15), (11), (4), (3), (3), (3), (3), (1)
Pubmed 3 references available
Catalog no. ABIN649376
Quantity 100 µL
Price
450.00 $   Plus shipping costs $45.00
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Specificity A synthetic peptide corresponding to residues in the exons 2 of human Bim was used as immunogen. The antibody can recognize all isoforms of Bim. The antibody does not cross-react with other Bcl-2 family members.
Alternative Name Bim
Background Bim, Bcl-2 interacting mediator of cell death, is a pro-apoptotic protein belonging to the BH3-only group of Bcl-2 family members (1). Bim promotes apoptosis by binding to and inhibiting the activity of anti-apoptotic Bcl-2 family members, inducing the release of cytochrome c from mitochondria (2). Bim is sequestered in an inactive conformation through binding to the microtubule-associated dynein motor complex. Certain apoptotic stimuli release Bim from microtubules, allowing inhibitory binding to anti-apoptotic Bcl-2 family members and subsequent iniation of apoptosis (3,4).
Molecular Weight 22 kDA
Gene ID 10018
UniProt O43521
Research Area Apoptosis/Necrosis, Phospho-specific antibodies, Protein Modifications, Cell Structure
Application Notes IHC: = 1:100, WB: = 1:1000-10000
Comment

Background: Bim, Bcl-2 interacting mediator of cell death, is a pro-apoptotic protein belonging to the BH3-only group of Bcl-2 family members (1). Bim promotes apoptosis by binding to and inhibiting the activity of anti-apoptotic Bcl-2 family members, inducing the release of cytochrome c from mitochondria (2). Bim is sequestered in an inactive conformation through binding to the microtubule-associated dynein motor complex. Certain apoptotic stimuli release Bim from microtubules, allowing inhibitory binding to anti-apoptotic Bcl-2 family members and subsequent iniation of apoptosis (3,4).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Storage -20 °C
Storage Comment Bim Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications OConnor, Strasser, OReilly et al.: "Bim: a novel member of the Bcl-2 family that promotes apoptosis." in: The EMBO journal, Vol. 17, Issue 2, pp. 384-95, 1998 (PubMed).

Hsu, Lin, Hsueh: "BOD (Bcl-2-related ovarian death gene) is an ovarian BH3 domain-containing proapoptotic Bcl-2 protein capable of dimerization with diverse antiapoptotic Bcl-2 members." in: Molecular endocrinology (Baltimore, Md.), Vol. 12, Issue 9, pp. 1432-40, 1998 (PubMed).

Puthalakath, Huang, OReilly et al.: "The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex." in: Molecular cell, Vol. 3, Issue 3, pp. 287-96, 1999 (PubMed).

Hosts (153), (17), (8), (7), (3)
Reactivities (171), (131), (112), (36), (36), (24), (1)
Applications (127), (63), (53), (40), (35), (34), (16), (15), (11), (4), (3), (3), (3), (3), (1)
Conjugates (5), (5), (4), (4), (4), (4), (4), (4), (4), (4), (4)
Epitopes (22), (13), (12), (12), (9), (7), (4), (4), (4), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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