SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 4 (SMARCA4) antibody

Details for Product No. ABIN649385
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Antigen
Synonyms SMARCA4, BAF190, BAF190A, BRG1, MRD16, RTPS2, SNF2, SNF2L4, SNF2LB, SWI2, hSNF2b, brg-1, Brg1, HP1-BP72, SNF2beta, SW1/SNF, b2b692Clo
Reactivity
Human
(59), (33), (32), (14)
Host
Rabbit
(42), (12), (5)
Clonality
Monoclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(41), (13), (10), (10), (8), (7), (6), (2), (2), (2)
Pubmed 1 reference available
Quantity 100 μL
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Catalog No. ABIN649385
392.86 $
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Specificity A synthetic peptide corresponding to residues near the C-terminus of human BRG1 protein was used as an immunogen.
Alternative Name BRG1
Background BRG1 protein (brahma-related gene 1) is a member of SWI/SNF family which mediates ATP-dependent chromatin remodeling processes. BRG is a central catalytic ATPase of the SWI/SNF chromatin-remodeling complex, where it uses the energy derived from ATP-hydrolysis to disrupt the chromatin architecture of target promoters. Considered a major co-regulator of transcription, BRG1 has been implicated in the activation and repression of gene expression through the modulation of chromatin in various tissues and physiological conditions. BRG1 appears to be a critical modulator of transcriptional regulation in cellular processes such as transcriptional regulation, replication, DNA repair and recombination (1, 2).
Molecular Weight 220 kDA
Gene ID 5966
UniProt P51532
Research Area Translation Factors, Signaling, Phospho-specific antibodies, Protein Modifications, Transcription Factors, Chromatin, Neurology, Metabolism, Cell Structure
Application Notes The suggested dilution is: WB: = 1:1000-10000
Comment

Background: BRG1 protein (brahma-related gene 1) is a member of SWI/SNF family which mediates ATP-dependent chromatin remodeling processes. BRG is a central catalytic ATPase of the SWI/SNF chromatin-remodeling complex, where it uses the energy derived from ATP-hydrolysis to disrupt the chromatin architecture of target promoters. Considered a major co-regulator of transcription, BRG1 has been implicated in the activation and repression of gene expression through the modulation of chromatin in various tissues and physiological conditions. BRG1 appears to be a critical modulator of transcriptional regulation in cellular processes such as transcriptional regulation, replication, DNA repair and recombination (1, 2).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment BRG1 Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Reisman, Glaros, Thompson: "The SWI/SNF complex and cancer." in: Oncogene, Vol. 28, Issue 14, pp. 1653-68, 2009 (PubMed).

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