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SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 4 (SMARCA4) antibody

Antigen

SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 4 (SMARCA4)
Synonyms BRG1, SNF2, SWI2, BAF190, SNF2L4, SNF2LB, hSNF2b, FLJ39786, SNF2-BETA, SMARCA4
Clonality Monoclonal
Host
Alternatives

Rabbit
Reactivity
Alternatives

Human
Application
Alternatives Western Blotting (WB)
1 reference available
Certificates ISO 9001:2008
Catalog no. ABIN649385
Quantity 100ul
Price 392.86 $   Plus shipping costs $45.00
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Additional Information
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Alternative name BRG1
Gene ID 5966
UniProt P51532
Characteristics Rabbit Monoclonal Antibody
Specificity A synthetic peptide corresponding to residues near the C-terminus of human BRG1 protein was used as an immunogen.
Molecular Weight 220 kDA
Comments

Background: BRG1 protein (brahma-related gene 1) is a member of SWI/SNF family which mediates ATP-dependent chromatin remodeling processes. BRG is a central catalytic ATPase of the SWI/SNF chromatin-remodeling complex, where it uses the energy derived from ATP-hydrolysis to disrupt the chromatin architecture of target promoters. Considered a major co-regulator of transcription, BRG1 has been implicated in the activation and repression of gene expression through the modulation of chromatin in various tissues and physiological conditions. BRG1 appears to be a critical modulator of transcriptional regulation in cellular processes such as transcriptional regulation, replication, DNA repair and recombination (1, 2).

Application Details
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Application Notes The suggested dilution is: WB: ~~ 1:1000~10000
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Storage BRG1 Antibody can be stored at -20°C for up to 12 months from time of receipt.
Research Area Translation Factors, Signaling, Phospho-specific antibodies, Protein Modifications, Transcription Factors, Chromatin, Neurology, Metabolism, Cell Structure
Restrictions For Research Use only

Publications
Application Details Alternatives back to top

Product Reisman, Glaros, Thompson: "The SWI/SNF complex and cancer." in: Oncogene, Vol. 28, Issue 14, pp. 1653-68, 2009 (PubMed).

Alternatives
Application Details Publications back to top

Alternatives for antigen "SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 4 (SMARCA4)", type "Antibodies"
Hosts Mouse (10), Rabbit (8), Goat (2)
Reactivities Human (18), Mouse (Murine) (5), Rat (Rattus) (5), Dog (Canine) (3), Hamster (2), Monkey (2)
Applications Western Blotting (WB) (15), ELISA (5), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (4), Immunofluorescence (IF) (2), Immunoprecipitation (IP) (2), Dot Blot (Dot) (1)
Epitopes C-Term (3), N-Term (3), AA 2-14 (2), AA 70-130 (1)