CCAAT/enhancer Binding Protein (C/EBP), alpha (CEBPA) (C-Term) antibody

Details for Product No. ABIN649389
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Antigen
Synonyms C/EBP-alpha, CEBP, C/ebpalpha, CBF-A, Cebp, DBPCEP, c/ebpa, cb1062, wu:fj20f03, C/EBP, C/EBPalpha, xC/EBP, cC/EBP, C/EBP alpha
Epitope
C-Term
(25), (20), (12), (12), (8), (7), (4), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Rat (Rattus)
(123), (84), (81), (38), (37), (25), (13), (2), (2), (2), (1), (1), (1)
Host
Rabbit
(106), (18), (2)
Clonality
Monoclonal
Conjugate
Un-conjugated
(4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (1), (1), (1)
Application
Western Blotting (WB)
(94), (50), (31), (30), (19), (14), (8), (6), (5), (2), (2), (1), (1)
Pubmed 3 references available
Quantity 100 µL
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Catalog No. ABIN649389
450.00 $
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Specificity A synthetic peptide corresponding to residues in the C-term of human C/EBP alpha was used as immunogen.
Alternative Name C/EBP alpha
Background CCAAT/enhancer-binding proteins (C/EBP) consist of a family of transcription factors that play an important role in regulating the balance between cell growth & differentiation. The various isoforms of C/EBP (α,,Beta,γ,,δ,,ε,, ζ, ) exhibit similar DNA-binding specificities and contain a leucine zipper dimerization domain (1). C/EBP alpha (2) can form heterodimers with related protein C/EBP beta and gamma. C/EBP alpha directly interacts with CDK2and CDK4 and arrests cell proliferation by inhibiting these kinases (3). C/EBP alpha has been shown to bind to the promoter and modulate the expression of leptin, a protein that plays an important role in body weight homeostasis (4). C/EBP alpha also has prominent antimitotic activity and may play a role of a tumor suppressor (5).
Synonyms: CEBPA, CCAAT/enhancer-binding protein alpha
Molecular Weight 43 kDA
Gene ID 1050
UniProt P49715
Research Area Translation Factors, Signaling, Protein Modifications, Transcription Factors, Cell Structure
Application Notes The suggested dilution is: WB: = 1: 500
Comment

Background: CCAAT/enhancer-binding proteins (C/EBP) consist of a family of transcription factors that play an important role in regulating the balance between cell growth & differentiation. The various isoforms of C/EBP (α,,β,,γ,,δ,,ε,, ζ, ) exhibit similar DNA-binding specificities and contain a leucine zipper dimerization domain (1). C/EBP alpha (2) can form heterodimers with related protein C/EBP beta and gamma. C/EBP alpha directly interacts with CDK2and CDK4 and arrests cell proliferation by inhibiting these kinases (3). C/EBP alpha has been shown to bind to the promoter and modulate the expression of leptin, a protein that plays an important role in body weight homeostasis (4). C/EBP alpha also has prominent antimitotic activity and may play a role of a tumor suppressor (5).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment C/EBP alpha Antibody (C-term) can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Miller, De Vos, Guerre-Millo et al.: "The adipocyte specific transcription factor C/EBPalpha modulates human ob gene expression." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 93, Issue 11, pp. 5507-11, 1996 (PubMed).

Timchenko, Wilde, Nakanishi et al.: "CCAAT/enhancer-binding protein alpha (C/EBP alpha) inhibits cell proliferation through the p21 (WAF-1/CIP-1/SDI-1) protein." in: Genes & development, Vol. 10, Issue 7, pp. 804-15, 1996 (PubMed).

Wang, Iakova, Wilde et al.: "C/EBPalpha arrests cell proliferation through direct inhibition of Cdk2 and Cdk4." in: Molecular cell, Vol. 8, Issue 4, pp. 817-28, 2001 (PubMed).

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