CCAAT/enhancer Binding Protein (C/EBP), beta (CEBPB) (C-Term) antibody

Details for Product No. ABIN649391
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Antigen
Synonyms
C/EBPbeta, c/ebp-beta, crp2, il6dbp, lap, nf-il6, tcf5, xC/EBPbeta, cebpbb, cb380, c/ebpb, fe11e05, wu:fe11e05, CEBPB, LOC100136165, C/EBP-beta, CRP2, IL6DBP, LAP, NF-IL6, TCF5, IL-6DBP, LIP, NF-M, Nf ... show more
C/EBPbeta, c/ebp-beta, crp2, il6dbp, lap, nf-il6, tcf5, xC/EBPbeta, cebpbb, cb380, c/ebpb, fe11e05, wu:fe11e05, CEBPB, LOC100136165, C/EBP-beta, CRP2, IL6DBP, LAP, NF-IL6, TCF5, IL-6DBP, LIP, NF-M, Nfil6, Il6dbp show less
Epitope
C-Term
(20), (13), (11), (8), (8), (6), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Rat (Rattus)
(102), (80), (59), (26), (26), (12), (12), (1)
Host
Rabbit
(89), (34), (2)
Clonality
Monoclonal
Conjugate
Un-conjugated
(3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3)
Application
Western Blotting (WB), Immunofluorescence (IF)
(90), (44), (30), (20), (20), (9), (8), (6), (6), (2), (1), (1)
Pubmed 3 references available
Quantity 100 µL
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Catalog No. ABIN649391
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Specificity A synthetic peptide corresponding to residues in C-terminus of rat C/EBP b was used as immunogen. The antibody can recognize three C/EBPb isoform (i.e. LAP*, LAP, and LIP).
Alternative Name C/EBP Beta
Background CCAAT/enhancer-binding proteins (C/EBP) consist of a family of transcription factors that play an important role in regulating the balance between cell growth & differentiation. The various isoforms of C/EBP (α,,Beta,γ,,δ,,ε,, ζ, ) exhibit similar DNA-binding specificities and contain a leucine zipper dimerization domain (1). A number of serine targets of PKA have been identified in C/EBP-Beta, suggesting its activities are post-translationally regulated by cAMP (2). Even though, it has been show that C/EBP Beta occurs predominantly as a heterodimer (3), C/EBP Beta & γ, readily heterodimerize with each other as well as with C/EBP α, (4). Additionally, 3 isoforms of C /EBP Beta can be detected (LAP*, LAP, & LIP) (5).
Synonyms: Cebpb, Crp2, Sfb, CCAAT/enhancer-binding protein beta, C/EBP-related protein 2
Molecular Weight 38/35/20 kDA
Gene ID 24253
UniProt P21272
Research Area Ubiquitin-related antibodies, Translation Factors, Phospho-specific antibodies, Protein Modifications, Cell Cycle, Transcription Factors, Signaling, Cell Structure
Application Notes The suggested dilution is: WB: = 1:500-1000
Comment

Background: CCAAT/enhancer-binding proteins (C/EBP) consist of a family of transcription factors that play an important role in regulating the balance between cell growth & differentiation. The various isoforms of C/EBP (α,,β,,γ,,δ,,ε,, ζ, ) exhibit similar DNA-binding specificities and contain a leucine zipper dimerization domain (1). A number of serine targets of PKA have been identified in C/EBP-β,, suggesting its activities are post-translationally regulated by cAMP (2). Even though, it has been show that C/EBP β, occurs predominantly as a heterodimer (3), C/EBP β, & γ, readily heterodimerize with each other as well as with C/EBP α, (4). Additionally, 3 isoforms of C /EBP β, can be detected (LAP*, LAP, & LIP) (5).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment C/EBP Beta Antibody (C-term) can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Thomassin, Hamel, Bernier et al.: "Molecular cloning of two C/EBP-related proteins that bind to the promoter and the enhancer of the alpha 1-fetoprotein gene. Further analysis of C/EBP beta and C/EBP gamma." in: Nucleic acids research, Vol. 20, Issue 12, pp. 3091-8, 1992 (PubMed).

Lekstrom-Himes, Xanthopoulos: "Biological role of the CCAAT/enhancer-binding protein family of transcription factors." in: The Journal of biological chemistry, Vol. 273, Issue 44, pp. 28545-8, 1998 (PubMed).

Parkin, Baer, Copeland et al.: "Regulation of CCAAT/enhancer-binding protein (C/EBP) activator proteins by heterodimerization with C/EBPgamma (Ig/EBP)." in: The Journal of biological chemistry, Vol. 277, Issue 26, pp. 23563-72, 2002 (PubMed).

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