Calcium/calmodulin-Dependent Protein Kinase II gamma (CAMK2G) antibody

Details for Product No. ABIN649424
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Antigen
Synonyms cam2, camk2, camk2g, camkII, camkb, CaMKII, R74975, mKIAA0968, CAMK, CAMK-II, CAMKG, 5930429P18Rik, Camkg
Reactivity
Human, Rat (Rattus)
(71), (52), (38), (14), (5), (3), (2), (2), (1), (1), (1), (1)
Host
Rabbit
(75), (13)
Clonality
Monoclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(75), (23), (23), (19), (12), (11), (10), (10), (5), (4), (4), (3), (1)
Pubmed 2 references available
Quantity 100 μL
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Catalog No. ABIN649424
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Specificity A synthetic peptide corresponding to residues on human CaMKII was used as an immunogen. The peptide immunogen is highly conserved between CaMKII-alpha, -beta, -gamma, and -omega.
Alternative Name CaMKII
Background Calcium/calmodulin-dependent protein kinase II (CaMKII) is a widely distributed protein kinase that regulates numerous physiological functions. Inhibitors of CaMKII are useful tools for investigating the CaMKII functions (1). The synapse contains densely localized and interacting proteins that enable it to adapt to changing inputs. A Ca2+-sensitive protein complex involved in the regulation of AMPA receptor synaptic plasticity. The complex is comprised of MUPPI, a multi-PDZ domain-containing protein, SynGAP, a synaptic GTPase-activating protein, and the Ca2+/calmodulin-dependent kinase CaMKII. In synapses of hippocampal neurons, SynGAP and CaMKII are brought together by direct physical interaction with the PDZ domains of MUPP1, and in this complex, SynGAP is phosphorylated. Ca2+CaM binding to CaMKII dissociates it from the MUPP1 complex, and Ca2+ entering via the NMDAR drives the dephosphorylation of SynGAP (2).
Synonyms: CAMK2A, CAMKA, KIAA0968, Calcium/calmodulin-dependent protein kinase type II alpha chain
Molecular Weight 45-70 kDA
Gene ID 815
UniProt Q9UQM7
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure, Signaling, Chromatin, Neurology
Application Notes IHC: = 1:100-250, WB: = 1:1000-5000
Comment

Background: Calcium/calmodulin-dependent protein kinase II (CaMKII) is a widely distributed protein kinase that regulates numerous physiological functions. Inhibitors of CaMKII are useful tools for investigating the CaMKII functions (1). The synapse contains densely localized and interacting proteins that enable it to adapt to changing inputs. A Ca2+-sensitive protein complex involved in the regulation of AMPA receptor synaptic plasticity. The complex is comprised of MUPPI, a multi-PDZ domain-containing protein, SynGAP, a synaptic GTPase-activating protein, and the Ca2+/calmodulin-dependent kinase CaMKII. In synapses of hippocampal neurons, SynGAP and CaMKII are brought together by direct physical interaction with the PDZ domains of MUPP1, and in this complex, SynGAP is phosphorylated. Ca2+CaM binding to CaMKII dissociates it from the MUPP1 complex, and Ca2+ entering via the NMDAR drives the dephosphorylation of SynGAP (2).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment CaMKII Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Zhang, Li, Yu et al.: "Molecular cloning and characterization of a novel calcium/calmodulin-dependent protein kinase II inhibitor from human dendritic cells." in: Biochemical and biophysical research communications, Vol. 285, Issue 2, pp. 229-34, 2001 (PubMed).

Krapivinsky, Medina, Krapivinsky et al.: "SynGAP-MUPP1-CaMKII synaptic complexes regulate p38 MAP kinase activity and NMDA receptor-dependent synaptic AMPA receptor potentiation." in: Neuron, Vol. 43, Issue 4, pp. 563-74, 2004 (PubMed).

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