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Details for Product No. ABIN649449

Cathepsin D (CTSD) antibody

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Antigen
Synonyms CLN10, CPSD, CD, CatD, catD, fb93e11, fj17b09, wu:fb93e11, wu:fj17b09, LOC398557, Cathd, LOC100136761, CTSD, DKFZp469J0315, DDBDRAFT_0205785, DDBDRAFT_0215012, DDB_0205785, DDB_0215012
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Monoclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC)
Pubmed 2 references available
Catalog no. ABIN649449
Quantity 100 µL
Price
450.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Specificity A synthetic peptide corresponding to residues near the N-terminus of human Cathepsin D was used as an immunogen.
Alternative Name Cathepsin D
Background Cathepsin D is a ubiquitously expressed lysosomal protease that is involved in proteolytic degradation, cell invasion, and apoptosis (1). It is suspected to play important roles in protein catabolism, antigen processing, degenerative diseases, and breast cancer progression (2). Cathepsin D is induced by estrogens in mammary cancer cells where its concentration is correlated with a higher risk of metastasis (3). It is possibly involved in Alzheimer',s disease-related neurodegeneration through cleavage of amyloid precursor protein into amyloidogenic components (4). Preprocathepsin D (43 kDa) is cleaved and glycosylated to form procathepsin D (46 kDa), and then further cleaved, forming light and a heavy chains (15 kDa and 28 kDa, respectively) (5).
Synonyms: CTSD, CPSD, Cathepsin D heavy chain
Molecular Weight ~46/15 kDA
Gene ID 1509
UniProt P07339
Research Area Cell Signaling, Protein Modifications, Neurology, Metabolism, Cell Structure
Application Notes The suggested dilution is: WB: ~~ 1:1000~2000 ICC: ~~ 1:100~250 IHC: ~~ 1:500
Comment

Background: Cathepsin D is a ubiquitously expressed lysosomal protease that is involved in proteolytic degradation, cell invasion, and apoptosis (1). It is suspected to play important roles in protein catabolism, antigen processing, degenerative diseases, and breast cancer progression (2). Cathepsin D is induced by estrogens in mammary cancer cells where its concentration is correlated with a higher risk of metastasis (3). It is possibly involved in Alzheimer',s disease-related neurodegeneration through cleavage of amyloid precursor protein into amyloidogenic components (4). Preprocathepsin D (43 kDa) is cleaved and glycosylated to form procathepsin D (46 kDa), and then further cleaved, forming light and a heavy chains (15 kDa and 28 kDa, respectively) (5).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Storage -20 °C
Storage Comment Cathepsin D Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Baldwin, Bhat, Gulnik et al.: "Crystal structures of native and inhibited forms of human cathepsin D: implications for lysosomal targeting and drug design." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 90, Issue 14, pp. 6796-800, 1993 (PubMed).

Steinfeld, Reinhardt, Schreiber et al.: "Cathepsin D deficiency is associated with a human neurodegenerative disorder." in: American journal of human genetics, Vol. 78, Issue 6, pp. 988-98, 2006 (PubMed).

Alternatives for antigen "Cathepsin D (CTSD)", type "Antibodies"
Hosts (107), (60), (1)
Reactivities (166), (29), (23), (12), (12), (12), (2)
Applications (110), (74), (57), (34), (17), (10), (6), (4), (4), (4), (4), (3), (3), (3), (2), (1), (1)
Conjugates (4), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (18), (7), (5), (5), (4), (4), (4), (4), (3), (2), (2), (2), (2), (1), (1), (1), (1)
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