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Cathepsin D (CTSD) antibody

Details for Product No. ABIN649450
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Antigen
Synonyms catD, fb93e11, fj17b09, wu:fb93e11, wu:fj17b09, LOC398557, Cathd, CatD, LOC100136761, CTSD, DKFZp469J0315, DDBDRAFT_0205785, DDBDRAFT_0215012, DDB_0205785, DDB_0215012, CLN10, CPSD, CD
Reactivity
Human
(180), (33), (27), (12), (12), (12), (2)
Host
Rabbit
(123), (66), (1)
Clonality
Monoclonal
Conjugate
Un-conjugated
(5), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(130), (94), (59), (45), (15), (15), (10), (7), (4), (3), (2), (2), (1), (1), (1)
Pubmed 2 references available
Quantity 100 µL
Options
Shipping to United States (Change)
Availability Will be delivered in 2 to 3 Business Days
Catalog No. ABIN649450
450.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Specificity A synthetic peptide corresponding to residues on the C terminus of human Cathepsin D was used as an immunogen.
Alternative Name Cathepsin D
Background Cathepsin D is a ubiquitously expressed lysosomal protease that is involved in proteolytic degradation, cell invasion, and apoptosis (1). It is suspected to play important roles in protein catabolism, antigen processing, degenerative diseases, and breast cancer progression (2). Cathepsin D is induced by estrogens in mammary cancer cells where its concentration is correlated with a higher risk of metastasis (3). It is possibly involved in Alzheimer's disease-related neurodegeneration through cleavage of amyloid precursor protein into amyloidogenic components (4). Preprocathepsin D (43 kDa) is cleaved and glycosylated to form procathepsin D (46 kDa), and then further cleaved, forming light and a heavy chains (15 kDa and 28 kDa, respectively) (5).
Synonyms: CTSD, CPSD, Cathepsin D heavy chain
Molecular Weight 28/43/46 kDA
Gene ID 1509
UniProt P07339
Research Area Cell Signaling, Protein Modifications, Metabolism, Neurology, Cell Structure
Application Notes IHC: = 1:500-1000, WB: = 1:10000-50000
Comment

Background: Cathepsin D is a ubiquitously expressed lysosomal protease that is involved in proteolytic degradation, cell invasion, and apoptosis (1). It is suspected to play important roles in protein catabolism, antigen processing, degenerative diseases, and breast cancer progression (2). Cathepsin D is induced by estrogens in mammary cancer cells where its concentration is correlated with a higher risk of metastasis (3). It is possibly involved in Alzheimer's disease-related neurodegeneration through cleavage of amyloid precursor protein into amyloidogenic components (4). Preprocathepsin D (43 kDa) is cleaved and glycosylated to form procathepsin D (46 kDa), and then further cleaved, forming light and a heavy chains (15 kDa and 28 kDa, respectively) (5).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Cathepsin D Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Baldwin, Bhat, Gulnik et al.: "Crystal structures of native and inhibited forms of human cathepsin D: implications for lysosomal targeting and drug design." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 90, Issue 14, pp. 6796-800, 1993 (PubMed).

Steinfeld, Reinhardt, Schreiber et al.: "Cathepsin D deficiency is associated with a human neurodegenerative disorder." in: American journal of human genetics, Vol. 78, Issue 6, pp. 988-98, 2006 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN649450
450.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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