anti-Cathepsin D antibody (CTSD)

Details for Product anti-CTSD Antibody No. ABIN649451
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Antigen
Synonyms catD, fb93e11, fj17b09, wu:fb93e11, wu:fj17b09, LOC398557, Cathd, CatD, LOC100136761, CTSD, DKFZp469J0315, DDBDRAFT_0205785, DDBDRAFT_0215012, DDB_0205785, DDB_0215012, CLN10, CPSD, CD
Reactivity
Human
(231), (38), (33), (2)
Host
Rabbit
(170), (79), (1), (1)
Clonality
Monoclonal
Conjugate
This Cathepsin D antibody is un-conjugated
(8), (6), (5), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(182), (131), (75), (61), (21), (18), (11), (10), (8), (7), (5), (3), (3), (3), (3), (2), (1), (1), (1)
Pubmed 2 references available
Quantity 100 μL
Options
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Specificity A synthetic peptide corresponding to residues on human Cathepsin D was used as an immunogen.
Alternative Name Cathepsin D (CTSD Antibody Abstract)
Background Cathepsin D is a ubiquitously expressed lysosomal protease that is involved in proteolytic degradation, cell invasion, and apoptosis (1). It is suspected to play important roles in protein catabolism, antigen processing, degenerative diseases, and breast cancer progression (2). Cathepsin D is induced by estrogens in mammary cancer cells where its concentration is correlated with a higher risk of metastasis (3). It is possibly involved in Alzheimer',s disease-related neurodegeneration through cleavage of amyloid precursor protein into amyloidogenic components (4). Preprocathepsin D (43 kDa) is cleaved and glycosylated to form procathepsin D (46 kDa), and then further cleaved, forming light and a heavy chains (15 kDa and 28 kDa, respectively) (5).
Synonyms: CTSD, CPSD, Cathepsin D heavy chain
Molecular Weight 46 kDA
Gene ID 1509
UniProt P07339
Research Area Cell Signaling, Protein Modifications, Neurology, Metabolism, Cell Structure
Application Notes The suggested dilution is: WB: = 1:20000-50000
Comment

Background: Cathepsin D is a ubiquitously expressed lysosomal protease that is involved in proteolytic degradation, cell invasion, and apoptosis (1). It is suspected to play important roles in protein catabolism, antigen processing, degenerative diseases, and breast cancer progression (2). Cathepsin D is induced by estrogens in mammary cancer cells where its concentration is correlated with a higher risk of metastasis (3). It is possibly involved in Alzheimer',s disease-related neurodegeneration through cleavage of amyloid precursor protein into amyloidogenic components (4). Preprocathepsin D (43 kDa) is cleaved and glycosylated to form procathepsin D (46 kDa), and then further cleaved, forming light and a heavy chains (15 kDa and 28 kDa, respectively) (5).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Cathepsin D Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Steinfeld, Reinhardt, Schreiber et al.: "Cathepsin D deficiency is associated with a human neurodegenerative disorder." in: American journal of human genetics, Vol. 78, Issue 6, pp. 988-98, 2006 (PubMed).

Baldwin, Bhat, Gulnik et al.: "Crystal structures of native and inhibited forms of human cathepsin D: implications for lysosomal targeting and drug design." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 90, Issue 14, pp. 6796-800, 1993 (PubMed).

Validation Images
Catalog No. ABIN649451
421.43 $
Plus shipping costs $45.00
Quantity
Price
100 μL
421.43 $

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