Membrane Metallo-Endopeptidase (MME) antibody

Details for Product No. ABIN649469
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Antigen
Synonyms MME, NEP, CD10, CALLA, CAK, CD167, DDR, EDDR1, HGK2, MCK10, NTRK4, PTK3, PTK3A, RTK6, TRKE, AV378681, Mmel, 6030454K05Rik, C85356, SFE, Nep
Reactivity
Human
(361), (59), (56), (18), (17), (17)
Host
Rabbit
(236), (136), (1)
Clonality
Monoclonal
Conjugate
Un-conjugated
(34), (33), (31), (14), (4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1)
Application
Western Blotting (WB)
(199), (138), (84), (73), (56), (51), (36), (28), (13), (11), (4), (3), (2), (1)
Pubmed 3 references available
Quantity 100 µL
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Catalog No. ABIN649469
450.00 $
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Specificity A synthetic peptide corresponding to residues on human CD10 was used as an immunogen.
Alternative Name CD10
Background The cluster designation (CD) antigens are cell surface molecules first defined on human leukocytes and later found to be expressed by a variety of human cell types in both normal and pathologic states. The common acute lymphoblastic leukemia antigen (CALLA/CD10) is a single-pass type II transmembrane metallo-endopeptidase that cleaves and inactivates a variety of peptide growth factors important for signal transduction including the enkephalins, bombesin, and substance P (1). It is expressed in a wide variety of epithelial and non-epithelial tissues, but its most significant application is in the diagnosis and classification of certain types of malignant lymphoma and leukemia. CD10 is expressed in a high percentage of cases of acute lymphoblastic leukemia, follicular lymphoma, Burkitt',s lymphoma, and some hematopoietic tumors (2). It is also known to be a marker of endometrial stromal cells, and was reported to be expressed in cells immediately surrounding the neoplastic glands invading the myometrium (3).
Synonyms: MME, EPN, Neprilysin, Enkephalinase,Atriopeptidase,Common acute lymphocytic leukemia antigen
Molecular Weight 100 kDA
Gene ID 4311
UniProt P08473
Research Area Cell Signaling, Protein Modifications, Cell Structure, Metabolism
Application Notes The suggested dilution is: WB: = 1:500
Comment

Background: The cluster designation (CD) antigens are cell surface molecules first defined on human leukocytes and later found to be expressed by a variety of human cell types in both normal and pathologic states. The common acute lymphoblastic leukemia antigen (CALLA/CD10) is a single-pass type II transmembrane metallo-endopeptidase that cleaves and inactivates a variety of peptide growth factors important for signal transduction including the enkephalins, bombesin, and substance P (1). It is expressed in a wide variety of epithelial and non-epithelial tissues, but its most significant application is in the diagnosis and classification of certain types of malignant lymphoma and leukemia. CD10 is expressed in a high percentage of cases of acute lymphoblastic leukemia, follicular lymphoma, Burkitt',s lymphoma, and some hematopoietic tumors (2). It is also known to be a marker of endometrial stromal cells, and was reported to be expressed in cells immediately surrounding the neoplastic glands invading the myometrium (3).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment CD10 Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications McIntosh, Lodge, Watson et al.: "NCL-CD10-270: a new monoclonal antibody recognizing CD10 in paraffin-embedded tissue." in: The American journal of pathology, Vol. 154, Issue 1, pp. 77-82, 1999 (PubMed).

DallEra, True, Siegel et al.: "Differential expression of CD10 in prostate cancer and its clinical implication." in: BMC urology, Vol. 7, pp. 3, 2007 (PubMed).

Ohishi, Kaku, Kobayashi et al.: "CD10 immunostaining distinguishes atypical polypoid adenomyofibroma (atypical polypoid adenomyoma) from endometrial carcinoma invading the myometrium." in: Human pathology, Vol. 39, Issue 10, pp. 1446-53, 2008 (PubMed).

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