No Products on your Comparison List.
Your basket is empty.
The Independent Validation Initiative strives to provide you with high quality data.
Find out more
Background: The cluster designation (CD) antigens are cell surface molecules first defined on human leukocytes and later found to be expressed by a variety of human cell types in both normal and pathologic states. The common acute lymphoblastic leukemia antigen (CALLA/CD10) is a single-pass type II transmembrane metallo-endopeptidase that cleaves and inactivates a variety of peptide growth factors important for signal transduction including the enkephalins, bombesin, and substance P (1). It is expressed in a wide variety of epithelial and non-epithelial tissues, but its most significant application is in the diagnosis and classification of certain types of malignant lymphoma and leukemia. CD10 is expressed in a high percentage of cases of acute lymphoblastic leukemia, follicular lymphoma, Burkitt',s lymphoma, and some hematopoietic tumors (2). It is also known to be a marker of endometrial stromal cells, and was reported to be expressed in cells immediately surrounding the neoplastic glands invading the myometrium (3).