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Background: CD10 is zinc-dependant metalloprotease enzyme that plays a role in the destruction of opiod peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond (1). CD10 is a cell-surface glycoprotein expressed on most acute lymphoblastic leukemias and certain other immature lymphoid malignancies and on normal lymphoid progenitors. The latter are either uncommitted to B- or T-cell lineage or committed to only the earliest stages of B- or T-lymphocyte maturation. CD10 is not restricted to leukemic cells, however, and is found on a variety of normal tissues. CD10 is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium (2). The proteolysis of beta-amyloid (Abeta) requires CD10, an enzyme that has been shown as reduced in Alzheimer's disease (AD). The defect of CD10 appears to correlate with Abeta deposition but not with degeneration and dementia (3).