Membrane Metallo-Endopeptidase (MME) antibody

Details for Product No. ABIN649470
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Antigen
Synonyms MME, NEP, CD10, CALLA, CAK, CD167, DDR, EDDR1, HGK2, MCK10, NTRK4, PTK3, PTK3A, RTK6, TRKE, AV378681, Mmel, 6030454K05Rik, C85356, SFE, Nep
Reactivity
Human, Rat (Rattus)
(371), (39), (37), (1)
Host
Rabbit
(259), (122), (1)
Clonality
Monoclonal
Conjugate
Un-conjugated
(39), (36), (35), (13), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(203), (139), (82), (76), (56), (49), (34), (20), (13), (12), (10), (4), (4), (3), (2), (1)
Pubmed 2 references available
Quantity 100 μL
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Catalog No. ABIN649470
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Specificity A synthetic peptide corresponding to residues on the N-terminus of human CD10 was used as an immogen.
Alternative Name CD10
Background CD10 is zinc-dependant metalloprotease enzyme that plays a role in the destruction of opiod peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond (1). CD10 is a cell-surface glycoprotein expressed on most acute lymphoblastic leukemias and certain other immature lymphoid malignancies and on normal lymphoid progenitors. The latter are either uncommitted to B- or T-cell lineage or committed to only the earliest stages of B- or T-lymphocyte maturation. CD10 is not restricted to leukemic cells, however, and is found on a variety of normal tissues. CD10 is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium (2). The proteolysis of beta-amyloid (Abeta) requires CD10, an enzyme that has been shown as reduced in Alzheimer's disease (AD). The defect of CD10 appears to correlate with Abeta deposition but not with degeneration and dementia (3).
Synonyms: MME, EPN, Neprilysin, Enkephalinase,Atriopeptidase,Common acute lymphocytic leukemia antigen
Molecular Weight 100 kDA
Gene ID 4311
UniProt P08473
Research Area Cell Signaling, Protein Modifications, Cell Structure, Metabolism
Application Notes The suggested dilution is: WB: = 1:5000-10000
Comment

Background: CD10 is zinc-dependant metalloprotease enzyme that plays a role in the destruction of opiod peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond (1). CD10 is a cell-surface glycoprotein expressed on most acute lymphoblastic leukemias and certain other immature lymphoid malignancies and on normal lymphoid progenitors. The latter are either uncommitted to B- or T-cell lineage or committed to only the earliest stages of B- or T-lymphocyte maturation. CD10 is not restricted to leukemic cells, however, and is found on a variety of normal tissues. CD10 is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium (2). The proteolysis of beta-amyloid (Abeta) requires CD10, an enzyme that has been shown as reduced in Alzheimer's disease (AD). The defect of CD10 appears to correlate with Abeta deposition but not with degeneration and dementia (3).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment CD10 Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Shipp, Richardson, Sayre et al.: "Molecular cloning of the common acute lymphoblastic leukemia antigen (CALLA) identifies a type II integral membrane protein." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 85, Issue 13, pp. 4819-23, 1988 (PubMed).

"The universal protein resource (UniProt)." in: Nucleic acids research, Vol. 36, Issue Database issue, pp. D190-5, 2008 (PubMed).

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