CD79a (IGBP1, Alpha 4 protein) is initially expressed at the pre B cell stage and persists until the plasma cell stage, where it is found as an intracellular component (1). CD79a associates with surface IgM-receptors, it has been implicated in signal transduction pathways and in the regulation of type 2A-related serine/threonine phosphatases catalytic activity (2). A disulfide-linked heterodimer, consisting of CD79a / mb-1 and CD79b / B29 polypeptides, non-covalently associates with membrane-bound immunoglobulins on B cells to constitute the B cell Ag receptor. CD79a is found in the majority of acute leukemias of precursor B cell type, B cell lines, B cell lymphomas, and some myelomas.
Synonyms: CD79A, IGA, MB1, B-cell antigen receptor complex-associated protein alpha chain, Ig-alpha,MB-1 membrane glycoprotein,Surface IgM-associated protein,Membrane-bound immunoglobulin-associated protein