CD79a/IGBP1 antibody

Antigen: CD79a/IGBP1

Clonality: Monoclonal

Host: Rabbit

Reactivity: Human

Application: Immunohistochemistry (IHC), Flow Cytometry (FACS)

Certificates: ISO 9001:2008

Catalog no.: ABIN649506

Additional Information

Gene ID: 973

UniProt: P11912

Description: Other names: CD79A, IGA, MB1, B-cell antigen receptor complex-associated protein alpha chain, Ig-alpha,MB-1 membrane glycoprotein,Surface IgM-associated protein,Membrane-bound immunoglobulin-associated protein

Characteristics: Rabbit Monoclonal Antibody

Specificity: A synthetic peptide derived from N-terminal region of human CD79a protein.

Molecular Weight: 50 kDA

Comments:

Background: CD79a (IGBP1, Alpha 4 protein) is initially expressed at the pre B cell stage and persists until the plasma cell stage, where it is found as an intracellular component (1). CD79a associates with surface IgM-receptors, it has been implicated in signal transduction pathways and in the regulation of type 2A-related serine/threonine phosphatases catalytic activity (2). A disulfide-linked heterodimer, consisting of CD79a / mb-1 and CD79b / B29 polypeptides, non-covalently associates with membrane-bound immunoglobulins on B cells to constitute the B cell Ag receptor. CD79a is found in the majority of acute leukemias of precursor B cell type, B cell lines, B cell lymphomas, and some myelomas.

Application Details

Application Notes: The suggested dilution is: FC: ~~ 1:10~100 IHC: ~~ 1:100~1:300

Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Storage: CD79a/IGBP1 Antibody can be stored at -20°C for up to 12 months from time of receipt.

Research Area: Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure

Restrictions: For Research Use only

Publications

Product: Mason, Cordell, Brown et al.: "CD79a: a novel marker for B-cell neoplasms in routinely processed tissue samples." in: Blood, Vol. 86, Issue 4, pp. 1453-9, 1995 (PubMed).