CD79a Molecule, Immunoglobulin-Associated alpha (CD79A) antibody

Details for Product No. ABIN649507
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Antigen
Synonyms CD79A, Ig-alpha, Iga, Igalpha, Ly-54, Ly54, mb-1, IGA, MB-1, IG-alpha
Reactivity
Human
(147), (38), (21), (20), (19), (19), (19), (19), (18), (9), (7), (6), (2), (1)
Host
Rabbit
(82), (80), (1)
Clonality
Monoclonal
Conjugate
Un-conjugated
(12), (10), (6), (5), (4), (3), (2), (2), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(82), (77), (56), (36), (25), (12), (10), (6), (5), (4), (3), (3), (2), (2)
Pubmed 1 reference available
Quantity 100 μL
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Catalog No. ABIN649507
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Specificity A synthetic peptide derived from the extracellular region of human CD79a protein.
Alternative Name CD79a/mb-1
Background CD79a (mb-1/ B lymphocyte-specific MB-1 protein) was originally identified on the basis of its restricted expression in lymphocytes of B lineage (1). CD79a associates with surface IgM-receptors, it has been implicated in the signal transduction pathways and in the regulation of type of type 2A-related serine/threonine phosphatases catalytic activity (2). A disulphide-linked heterodimer, consisting of CD79a (mb-1) and CD79b / B29 polypeptides, non-covalently associates with membrane-bound immunoglobulins on B cells to constitute the B cell Ag receptor. CD79 is required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also CD79 interacts with and increases activity of some Src-family tyrosine kinases. (3).
Synonyms: CD79A, IGA, MB1, B-cell antigen receptor complex-associated protein alpha chain, Ig-alpha,MB-1 membrane glycoprotein,Surface IgM-associated protein,Membrane-bound immunoglobulin-associated protein
Molecular Weight 44 - 48 kDA
Gene ID 973
UniProt P11912
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure
Application Notes IHC: = 1:100-250, WB: = 1:5000-20000
Comment

Background: CD79a (mb-1/ B lymphocyte-specific MB-1 protein) was originally identified on the basis of its restricted expression in lymphocytes of B lineage (1). CD79a associates with surface IgM-receptors, it has been implicated in the signal transduction pathways and in the regulation of type of type 2A-related serine/threonine phosphatases catalytic activity (2). A disulphide-linked heterodimer, consisting of CD79a (mb-1) and CD79b / B29 polypeptides, non-covalently associates with membrane-bound immunoglobulins on B cells to constitute the B cell Ag receptor. CD79 is required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also CD79 interacts with and increases activity of some Src-family tyrosine kinases. (3).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment CD79a/mb-1 Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Mason, Cordell, Brown et al.: "CD79a: a novel marker for B-cell neoplasms in routinely processed tissue samples." in: Blood, Vol. 86, Issue 4, pp. 1453-9, 1995 (PubMed).

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