CD9 (CD9) antibody

Details for Product No. ABIN649511
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Antigen
Synonyms Tspan29, BTCC-1, DRAP-27, MIC3, MRP-1, TSPAN-29, TSPAN29
Reactivity
Human, Rat (Rattus)
(259), (84), (35), (30), (26), (19), (15), (13), (12), (6), (2), (1), (1)
Host
Rabbit
(201), (69), (51)
Clonality
Monoclonal
Conjugate
Un-conjugated
(44), (44), (27), (9), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(245), (129), (53), (50), (48), (46), (33), (30), (23), (19), (13), (10), (6), (3), (2), (2), (2), (1), (1)
Pubmed 6 references available
Quantity 100 μL
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Catalog No. ABIN649511
450.00 $
Plus shipping costs $45.00

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  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Specificity A synthetic peptide corresponding to residues in human CD9 was used as an immunogen.
Alternative Name CD9
Background CD9 belongs to the transmembrane 4 superfamily, also known as tetraspanin (TM4SF) family and is expressed in variety of hematopoietic and epithelial cells (1,2). It can form homodimers or homooligomers as well as heterooligomers with other members of the TM4SF family (3,4). It can trigger platelet activation and aggregation and modulate cell adhesion and migration. In addition, CD9 appears to promote muscle cell fusion and support. Downregualtion of CD9 has been reported to be associated with tumor progression and metastasis (5,6).
Synonyms: CD9, MIC3, TSPAN29, CD9 antigen, 5H9 antigen,Cell growth-inhibiting gene 2 protein
Molecular Weight 24 kDA
Gene ID 4773
UniProt P21926
Research Area Cell Structure
Application Notes IHC: = 1:100-250, WB: = 1:1000-10000
Comment

Background: CD9 belongs to the transmembrane 4 superfamily, also known as tetraspanin (TM4SF) family and is expressed in variety of hematopoietic and epithelial cells (1,2). It can form homodimers or homooligomers as well as heterooligomers with other members of the TM4SF family (3,4). It can trigger platelet activation and aggregation and modulate cell adhesion and migration. In addition, CD9 appears to promote muscle cell fusion and support. Downregualtion of CD9 has been reported to be associated with tumor progression and metastasis (5,6).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment CD9 Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Lanza, Wolf, Fox et al.: "cDNA cloning and expression of platelet p24/CD9. Evidence for a new family of multiple membrane-spanning proteins." in: The Journal of biological chemistry, Vol. 266, Issue 16, pp. 10638-45, 1991 (PubMed).

Rubinstein, Benoit, Billard et al.: "Organization of the human CD9 gene." in: Genomics, Vol. 16, Issue 1, pp. 132-8, 1993 (PubMed).

Rubinstein, Le Naour, Lagaudrière-Gesbert et al.: "CD9, CD63, CD81, and CD82 are components of a surface tetraspan network connected to HLA-DR and VLA integrins." in: European journal of immunology, Vol. 26, Issue 11, pp. 2657-65, 1997 (PubMed).

Charrin, Le Naour, Oualid et al.: "The major CD9 and CD81 molecular partner. Identification and characterization of the complexes." in: The Journal of biological chemistry, Vol. 276, Issue 17, pp. 14329-37, 2001 (PubMed).

Wang, Bégin, Bérubé et al.: "Down-regulation of CD9 expression during prostate carcinoma progression is associated with CD9 mRNA modifications." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 13, Issue 8, pp. 2354-61, 2007 (PubMed).

De Bruyne, Bos, Asosingh et al.: "Epigenetic silencing of the tetraspanin CD9 during disease progression in multiple myeloma cells and correlation with survival." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 14, Issue 10, pp. 2918-26, 2008 (PubMed).

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