CD90 (THY1) antibody

Details for Product No. ABIN649513
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Antigen
Synonyms CD90, CD7, T25, Thy-1, Thy-1.2, Thy1.1, Thy1.2
Reactivity
Human
(312), (142), (122), (27), (23), (14), (14), (11), (5), (4), (2), (1)
Host
Rabbit
(221), (205), (74), (4)
Clonality
Monoclonal
Conjugate
Un-conjugated
(66), (64), (45), (23), (10), (7), (4), (4), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(375), (102), (99), (62), (49), (45), (34), (32), (23), (17), (10), (6), (2), (2), (2), (1), (1), (1)
Pubmed 3 references available
Quantity 100 µL
Options
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Catalog No. ABIN649513
450.00 $
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Specificity A synthetic peptide corresponding to residues near the N-terminal of human CD90 was used as an immunogen.
Alternative Name CD90
Background CD90 (Cluster of Differentiation 90, Thy-1) is a heavily N-glycosylated GPI linked cell surface protein member of the immunoglobulin (Ig) superfamily. As a smallest member of family, CD90 may play a role in cell-to-cell and cell-to-ligand interactions during synaptogensis and other neuron related activities (e.g. neurite outgrowth, nerve regeneration) (1). In developing nervous tissue, CD90 is involved in axon growth regulation by halting axon growth in mature axon via its interaction with intergin-beta-3 on mature astrocytes. Additionally, CD90 has been linked to apoptosis, adhesion, migration, cancer (including cancer stem cells), and fibrosis (2). As a major marker for hematopoietic stem cells (HSCs), CD90 mediates differentiation of HSCs. In stem cancer cell research, CD90 positive cells in the hepatocellular carcinoma (HCC) have been shown to display tumorigenic capacity (3).
Synonyms: THY1, Thy-1 membrane glycoprotein, Thy-1 antigen,CDw90
Molecular Weight 25-35 kDA
Gene ID 6657
UniProt P04216
Research Area Cell Signaling, Protein Modifications, Cell Structure
Application Notes IHC: = 1:100-250, WB: = 1:1000-5000
Comment

Background: CD90 (Cluster of Differentiation 90, Thy-1) is a heavily N-glycosylated GPI linked cell surface protein member of the immunoglobulin (Ig) superfamily. As a smallest member of family, CD90 may play a role in cell-to-cell and cell-to-ligand interactions during synaptogensis and other neuron related activities (e.g. neurite outgrowth, nerve regeneration) (1). In developing nervous tissue, CD90 is involved in axon growth regulation by halting axon growth in mature axon via its interaction with intergin-beta-3 on mature astrocytes. Additionally, CD90 has been linked to apoptosis, adhesion, migration, cancer (including cancer stem cells), and fibrosis (2). As a major marker for hematopoietic stem cells (HSCs), CD90 mediates differentiation of HSCs. In stem cancer cell research, CD90 positive cells in the hepatocellular carcinoma (HCC) have been shown to display tumorigenic capacity (3).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment CD90 Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Rege, Hagood: "Thy-1 as a regulator of cell-cell and cell-matrix interactions in axon regeneration, apoptosis, adhesion, migration, cancer, and fibrosis." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 20, Issue 8, pp. 1045-54, 2006 (PubMed).

"The universal protein resource (UniProt)." in: Nucleic acids research, Vol. 36, Issue Database issue, pp. D190-5, 2008 (PubMed).

Yang, Ho, Ng et al.: "Significance of CD90+ cancer stem cells in human liver cancer." in: Cancer cell, Vol. 13, Issue 2, pp. 153-66, 2008 (PubMed).

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