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Details for Product No. ABIN649545

Jun Proto-Oncogene (JUN) (N-Term) antibody

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Antigen
Synonyms p39, B230310J22Rik, AP1, AP-1, c-Jun, Junc, c-jun, Jun, JUN, fj36h07, zgc:65863, wu:fj36h07
Epitope
»Alternatives N-Term
Reactivity
»Alternatives Human, Rat (Rattus)
Host
»Alternatives Rabbit
Clonality Monoclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP)
Pubmed 4 references available
Catalog no. ABIN649545
Quantity 100 µL
Price
450.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Specificity A synthetic peptide corresponding to N-terminal residues of human c-Jun was used as immunogen. Predicted to cross-react with pig, based on sequence homology.
Alternative Name c-Jun
Background C-Jun is a component of the transcription factor AP-1 (1). The transcriptional activity of c-Jun is regulated by phosphorylation at serines 63 and 73 (1,2). Extracellular signals, including growth factors, transforming oncoproteins and UV light, stimulate phosphorylation of c-Jun at Ser63/73 and activate c-Jun-dependent transcription (3,4).
Synonyms: JUN, Transcription factor AP-1, Proto-oncogene c-jun,V-jun avian sarcoma virus 17 oncogene homolog,p39
Molecular Weight 43 kDA
Gene ID 3725
UniProt P05412
Research Area Phospho-specific antibodies, Protein Modifications, Cancer, Transcription Factors, Signaling, Cell Structure
Application Notes The suggested dilution is: WB: ~~ 1:2500 IP: ~~ 1:40 ICC: ~~ 1:250 IHC: ~~ 1:250
Comment

Background: c-Jun is a component of the transcription factor AP-1 (1). The transcriptional activity of c-Jun is regulated by phosphorylation at serines 63 and 73 (1,2). Extracellular signals, including growth factors, transforming oncoproteins and UV light, stimulate phosphorylation of c-Jun at Ser63/73 and activate c-Jun-dependent transcription (3,4).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Storage -20 °C
Storage Comment c-Jun Antibody (N-term) can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Smeal, Binetruy, Mercola et al.: "Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73." in: Nature, Vol. 354, Issue 6353, pp. 494-6, 1992 (PubMed).

Bohmann, Bos, Admon et al.: "Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1." in: Science (New York, N.Y.), Vol. 238, Issue 4832, pp. 1386-92, 1988 (PubMed).

Dérijard, Hibi, Wu et al.: "JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain." in: Cell, Vol. 76, Issue 6, pp. 1025-37, 1994 (PubMed).

Kyriakis, Banerjee, Nikolakaki et al.: "The stress-activated protein kinase subfamily of c-Jun kinases." in: Nature, Vol. 369, Issue 6476, pp. 156-60, 1994 (PubMed).

Alternatives for antigen "Jun Proto-Oncogene (JUN)", type "Antibodies"
Hosts (535), (54), (3), (1), (1)
Reactivities (579), (403), (372), (155), (153), (151), (140), (11), (7), (7), (4), (4), (4), (3), (3), (3), (2), (2), (2), (1)
Applications (443), (187), (165), (141), (119), (61), (48), (23), (20), (14), (8), (7), (1), (1), (1)
Conjugates (12), (12), (12), (12), (12), (12), (12), (12), (12), (12), (12)
Epitopes (68), (57), (50), (42), (32), (32), (22), (15), (13), (10), (8), (5), (5), (4), (4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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