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Jun Proto-Oncogene (JUN) (pSer63) antibody

Details for Product No. ABIN649546
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Antigen
Synonyms
BSK, BSK/DJNK, Bsk, CG5680, D-JNK, D-junk, DBSK/JNK, DJNK, DJNK/bsk, Dmel\\CG5680, JNK, JNK/SAPK, Jnk, Junk, SAPKa, c-Jun, dJNK, jnk, Jun, AP-1, JUN, B230310J22Rik, p39, Junc, c-jun, AP1, fj36h07, wu: ... show more
BSK, BSK/DJNK, Bsk, CG5680, D-JNK, D-junk, DBSK/JNK, DJNK, DJNK/bsk, Dmel\\CG5680, JNK, JNK/SAPK, Jnk, Junk, SAPKa, c-Jun, dJNK, jnk, Jun, AP-1, JUN, B230310J22Rik, p39, Junc, c-jun, AP1, fj36h07, wu:fj36h07, zgc:65863, CG2275, D-Jun, D-jun, D-jun/Jra, DJUN, DJun, Djun, Dmel\\CG2275, JRA, V, cJun, d-JRA, d-Jun, d-jun, dAP-1, dJRA, dJUN, dJra, dJun, djun, dm-Jun, jra, jun, l(2)46Ef, l(2)IA109, l(2R)IA109 show less
Epitope
pSer63
(70), (59), (54), (44), (37), (34), (28), (19), (15), (13), (12), (9), (8), (7), (6), (5), (5), (4), (4), (4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Rat (Rattus)
(603), (413), (371), (154), (152), (150), (139), (10), (7), (6), (3), (3), (3), (3), (3), (2), (2), (2), (2), (1)
Host
Rabbit
(566), (56), (2), (1), (1)
Clonality
Monoclonal
Conjugate
Un-conjugated
(16), (16), (16), (12), (12), (12), (12), (12), (12), (12), (12), (4), (4), (4)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(464), (230), (167), (119), (113), (68), (49), (43), (19), (8), (8), (8), (2), (1), (1)
Pubmed 4 references available
Quantity 100 µL
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Catalog No. ABIN649546
507.14 $
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Specificity A synthetic phospho-peptide corresponding to residues surrounding Serine 63 of human c-Jun was used as immunogen. The antibody only detects c-Jun phosphorylated on Serine 63. Predicted to cross-react with bovine, based on sequence homology.
Alternative Name c-Jun
Background C-Jun is a component of the transcription factor AP-1 (1). The transcriptional activity of c-Jun is regulated by phosphorylation at serines 63 and 73 (1,2). Extracellular signals, including growth factors, transforming oncoproteins and UV light, stimulate phosphorylation of c-Jun at Ser63/73 and activate c-Jun-dependent transcription (3,4).
Synonyms: JUN, Transcription factor AP-1, Proto-oncogene c-jun,V-jun avian sarcoma virus 17 oncogene homolog,p39
Molecular Weight 48 kDA
Gene ID 3725
UniProt P05412
Research Area Phospho-specific antibodies, Protein Modifications, Cancer, Transcription Factors, Signaling, Cell Structure
Application Notes IHC: = 1:50-100, WB: = 1:500
Comment

Background: c-Jun is a component of the transcription factor AP-1 (1). The transcriptional activity of c-Jun is regulated by phosphorylation at serines 63 and 73 (1,2). Extracellular signals, including growth factors, transforming oncoproteins and UV light, stimulate phosphorylation of c-Jun at Ser63/73 and activate c-Jun-dependent transcription (3,4).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment c-Jun Antibody Phospho (pS63) can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Smeal, Binetruy, Mercola et al.: "Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73." in: Nature, Vol. 354, Issue 6353, pp. 494-6, 1992 (PubMed).

Bohmann, Bos, Admon et al.: "Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1." in: Science (New York, N.Y.), Vol. 238, Issue 4832, pp. 1386-92, 1988 (PubMed).

Dérijard, Hibi, Wu et al.: "JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain." in: Cell, Vol. 76, Issue 6, pp. 1025-37, 1994 (PubMed).

Kyriakis, Banerjee, Nikolakaki et al.: "The stress-activated protein kinase subfamily of c-Jun kinases." in: Nature, Vol. 369, Issue 6476, pp. 156-60, 1994 (PubMed).

Validation Images
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