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Mast/stem Cell Growth Factor Receptor (KIT) (C-Term) antibody

Details for Product No. ABIN649550
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Antigen
Synonyms Bs, CD117, Fdc, Gsfsco1, Gsfsco5, Gsfsow3, SCO1, SCO5, SOW3, Ssm, Tr-kit, W, c-KIT, C-Kit, PBT, SCFR, MGF, c-kit
Epitope
C-Term
(65), (56), (36), (34), (20), (20), (20), (20), (19), (19), (13), (13), (12), (12), (10), (9), (9), (8), (7), (7), (7), (7), (7), (7), (7), (7), (7), (7), (7), (7), (7), (7), (7), (7), (7), (7), (7), (7), (7), (7), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (5), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(654), (341), (153), (104), (102), (91), (22), (5)
Host
Rabbit
(556), (154), (138), (3), (1), (1)
Clonality
Monoclonal
Conjugate
Un-conjugated
(79), (73), (72), (59), (47), (37), (19), (10), (10), (10), (10), (10), (10), (10), (7), (6), (6), (4), (4), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(299), (298), (267), (142), (121), (104), (75), (32), (31), (27), (16), (10), (7), (3), (2), (1)
Pubmed 4 references available
Quantity 100 µL
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Catalog No. ABIN649550
450.00 $
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  • +1 404 474 4654
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Specificity A synthetic peptide corresponding to residues in the C-terminus (cytoplasmic domain) of human c-Kit was used as an immunogen. The antibody does not cross-react with other CSF-1/PDGF receptor family member.
Alternative Name c-Kit/CD117
Background Member of the Tyrosine Kinase Receptor (TKRs) and highly homologous to receptor PDF and CSF-1 (1-2), c-Kit is a cellular homologue of the oncogene v-Kit of the Hardy Zuckerman 4-feline sarcoma virus (3). Activation of c-Kit tyrosine kinase by SCF (Stem Cell factor) leads to autophosphorylation and association of c-Kit with substrate PI3K (4). Missense substitution within the cellular tyrosine kinase may cause Piebaldism an autosomal dominant disorder of the skin (5).
Synonyms: KIT, Mast/stem cell growth factor receptor, Proto-oncogene tyrosine-protein kinase Kit
Molecular Weight 145 kDA
Gene ID 3815
UniProt P10721
Research Area Ubiquitin-related antibodies, Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure, Cancer, Signaling, Chromatin
Application Notes IHC: = 1:50-100, WB: = 1:1000-10000
Comment

Background: Member of the Tyrosine Kinase Receptor (TKRs) and highly homologous to receptor PDF and CSF-1 (1-2), c-Kit is a cellular homologue of the oncogene v-Kit of the Hardy Zuckerman 4-feline sarcoma virus (3). Activation of c-Kit tyrosine kinase by SCF (Stem Cell factor) leads to autophosphorylation and association of c-Kit with substrate PI3K (4). Missense substitution within the cellular tyrosine kinase may cause Piebaldism an autosomal dominant disorder of the skin (5).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment c-Kit/CD117 Antibody (C-term) can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Spritz, Giebel, Holmes: "Dominant negative and loss of function mutations of the c-kit (mast/stem cell growth factor receptor) proto-oncogene in human piebaldism." in: American journal of human genetics, Vol. 50, Issue 2, pp. 261-9, 1992 (PubMed).

Yarden, Kuang, Yang-Feng et al.: "Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand." in: The EMBO journal, Vol. 6, Issue 11, pp. 3341-51, 1988 (PubMed).

Qiu, Ray, Brown et al.: "Primary structure of c-kit: relationship with the CSF-1/PDGF receptor kinase family--oncogenic activation of v-kit involves deletion of extracellular domain and C terminus." in: The EMBO journal, Vol. 7, Issue 4, pp. 1003-11, 1988 (PubMed).

Besmer, Murphy, George et al.: "A new acute transforming feline retrovirus and relationship of its oncogene v-kit with the protein kinase gene family." in: Nature, Vol. 320, Issue 6061, pp. 415-21, 1986 (PubMed).

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