No Products on your Comparison List.
Your basket is empty.
The Independent Validation Initiative strives to provide you with high quality data.
Find out more
Background: Member of the Tyrosine Kinase Receptor (TKRs) and highly homologous to receptor PDF and CSF-1 (1-2), c-Kit is a cellular homologue of the oncogene v-Kit of the Hardy Zuckerman 4-feline sarcoma virus (3). Activation of c-Kit tyrosine kinase by SCF (Stem Cell factor) leads to autophosphorylation and association of c-Kit with substrate PI3K (4). Missense substitution within the cellular tyrosine kinase may cause Piebaldism an autosomal dominant disorder of the skin (5).