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C-Reactive (C-Term) antibody

Details for Product No. ABIN649562
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Antigen
Epitope
C-Term
(1)
Reactivity
Human
(1)
Host
Rabbit
(1)
Clonality
Monoclonal
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(1)
Pubmed 5 references available
Quantity 100 µL
Options
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Availability Will be delivered in 2 to 3 Business Days
Catalog No. ABIN649562
450.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Specificity A synthetic peptide corresponding to residues in the C-term of human c-Reactive protein was used as immunogen. This antibody is predicted to detect the splice isoform 2.
Background Human c-Reactive protein (CRP) was discovered in serum of patients as a nonantibody precipitin of the C-polysaccharide from pneumococci(1). During acute infection, the amounts of circulating CPR increases 100-1000 fold (2). Serum CRP values are routinely measured to detect or monitor many human diseases and minor elevations of C-reactive protein are predictive of cardiovascular events in patients with coronary heart disease (3). CRP promotes host defense, is an efficient activator of the classical C cascade, and shown to be opsonic (4).The opsonic and C activation activities are responsible for the nonspecific host defense activities providing protection in the preimmune stage of acute infections. Additionally, IL-1 and IL-6 are known to stimulate CRP biosyntesis (5).
Synonyms: CRP, PTX1, C-reactive protein(1-205)
Molecular Weight 23/117.5 kDA
Gene ID 1401
UniProt P02741
Research Area Cell Signaling, Protein Modifications, Cell Structure
Application Notes IHC: = 1:100-250, WB: = 1:1000
Comment

Background: Human c-Reactive protein (CRP) was discovered in serum of patients as a nonantibody precipitin of the C-polysaccharide from pneumococci(1). During acute infection, the amounts of circulating CPR increases 100-1000 fold (2). Serum CRP values are routinely measured to detect or monitor many human diseases and minor elevations of C-reactive protein are predictive of cardiovascular events in patients with coronary heart disease (3). CRP promotes host defense, is an efficient activator of the classical C cascade, and shown to be opsonic (4).The opsonic and C activation activities are responsible for the nonspecific host defense activities providing protection in the preimmune stage of acute infections. Additionally, IL-1 and IL-6 are known to stimulate CRP biosyntesis (5).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment C-reactive Antibody (C-term) can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Mortensen, Osmand, Lint et al.: "Interaction of C-reactive protein with lymphocytes and monocytes: complement-dependent adherence and phagocytosis." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 117, Issue 3, pp. 774-81, 1976 (PubMed).

Kushner: "The phenomenon of the acute phase response." in: Annals of the New York Academy of Sciences, Vol. 389, pp. 39-48, 1982 (PubMed).

Kleemann, Gervois, Verschuren et al.: "Fibrates down-regulate IL-1-stimulated C-reactive protein gene expression in hepatocytes by reducing nuclear p50-NFkappa B-C/EBP-beta complex formation." in: Blood, Vol. 101, Issue 2, pp. 545-51, 2003 (PubMed).

Ridker, Rifai, Rose et al.: "Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events." in: The New England journal of medicine, Vol. 347, Issue 20, pp. 1557-65, 2002 (PubMed).

Ohara, Granato, Moallem et al.: "Dopaminergic input to GABAergic neurons in the rostral agranular insular cortex of the rat." in: Journal of neurocytology, Vol. 32, Issue 2, pp. 131-41, 2004 (PubMed).

Hosts (1)
Reactivities (1)
Applications (1)
Epitopes (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN649562
450.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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