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C-Reactive (C-Term) antibody

Details for Product No. ABIN649563
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Antigen
Epitope
C-Term
(1)
Reactivity
Human
(1)
Host
Rabbit
(1)
Clonality
Monoclonal
Application
Western Blotting (WB)
(1), (1)
Pubmed 4 references available
Quantity 100 µL
Options
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Availability Will be delivered in 2 to 3 Business Days
Catalog No. ABIN649563
392.86 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Specificity A synthetic peptide corresponding to residues near the N-term of human C-reactive protein was used as immunogen.
Background Human C-reactive protein (CRP) was discovered in serum of patients as a nonantibody precipitin of the C-polysaccharide from pneumococci(1). During acute infection, the amounts of circulating CPR increases 100-1000 fold (2). Serum CRP values are routinely measured to detect or monitor many human diseases and minor elevations of C-reactive protein are predictive of cardiovascular events in patients with coronary heart disease (3). CRP promotes host defense, is an efficient activator of the classical C cascade, and shown to be opsonic (4).The opsonic and C activation activities are responsible for the nonspecific host defense activities providing protection in the preimmune stage of acute infections. Additionally, IL-1 and IL-6 are known to stimulate CRP biosyntesis (5).
Synonyms: CRP, PTX1, C-reactive protein(1-205)
Molecular Weight 23/117.5 kDA
Gene ID 1401
UniProt P02741
Research Area Cell Signaling, Protein Modifications, Cell Structure
Application Notes The suggested dilution is: WB: = 1:1000
Comment

Background: Human C-reactive protein (CRP) was discovered in serum of patients as a nonantibody precipitin of the C-polysaccharide from pneumococci(1). During acute infection, the amounts of circulating CPR increases 100-1000 fold (2). Serum CRP values are routinely measured to detect or monitor many human diseases and minor elevations of C-reactive protein are predictive of cardiovascular events in patients with coronary heart disease (3). CRP promotes host defense, is an efficient activator of the classical C cascade, and shown to be opsonic (4).The opsonic and C activation activities are responsible for the nonspecific host defense activities providing protection in the preimmune stage of acute infections. Additionally, IL-1 and IL-6 are known to stimulate CRP biosyntesis (5).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment C-reactive Antibody (C-term) can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Mortensen, Osmand, Lint et al.: "Interaction of C-reactive protein with lymphocytes and monocytes: complement-dependent adherence and phagocytosis." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 117, Issue 3, pp. 774-81, 1976 (PubMed).

Kleemann, Gervois, Verschuren et al.: "Fibrates down-regulate IL-1-stimulated C-reactive protein gene expression in hepatocytes by reducing nuclear p50-NFkappa B-C/EBP-beta complex formation." in: Blood, Vol. 101, Issue 2, pp. 545-51, 2003 (PubMed).

Ridker, Rifai, Rose et al.: "Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events." in: The New England journal of medicine, Vol. 347, Issue 20, pp. 1557-65, 2002 (PubMed).

Ohara, Granato, Moallem et al.: "Dopaminergic input to GABAergic neurons in the rostral agranular insular cortex of the rat." in: Journal of neurocytology, Vol. 32, Issue 2, pp. 131-41, 2004 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN649563
392.86 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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