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C-reactive (C-Term) antibody
Alternatives Western Blotting (WB)
|4 references available|
|Price||392.86 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Description||Other names: CRP, PTX1, C-reactive protein(1-205)|
|Characteristics||Rabbit Monoclonal Antibody|
|Specificity||A synthetic peptide corresponding to residues near the N-term of human C-reactive protein was used as immunogen.|
|Molecular Weight||23/117.5 kDA|
Background: Human C-reactive protein (CRP) was discovered in serum of patients as a nonantibody precipitin of the C-polysaccharide from pneumococci(1). During acute infection, the amounts of circulating CPR increases 100-1000 fold (2). Serum CRP values are routinely measured to detect or monitor many human diseases and minor elevations of C-reactive protein are predictive of cardiovascular events in patients with coronary heart disease (3). CRP promotes host defense, is an efficient activator of the classical C cascade, and shown to be opsonic (4).The opsonic and C activation activities are responsible for the nonspecific host defense activities providing protection in the preimmune stage of acute infections. Additionally, IL-1 and IL-6 are known to stimulate CRP biosyntesis (5).
|Application Notes||The suggested dilution is: WB: ~~ 1:1000|
|Buffer||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||C-reactive Antibody (C-term) can be stored at -20°C for up to 12 months from time of receipt.|
|Research Area||Cell Signaling, Protein Modifications, Cell Structure|
|Restrictions||For Research Use only|
Mortensen, Osmand, Lint et al.: "Interaction of C-reactive protein with lymphocytes and monocytes: complement-dependent adherence and phagocytosis." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 117, Issue 3, pp. 774-81, 1976 (PubMed).
Kleemann, Gervois, Verschuren et al.: "Fibrates down-regulate IL-1-stimulated C-reactive protein gene expression in hepatocytes by reducing nuclear p50-NFkappa B-C/EBP-beta complex formation." in: Blood, Vol. 101, Issue 2, pp. 545-51, 2003 (PubMed).
Ridker, Rifai, Rose et al.: "Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events." in: The New England journal of medicine, Vol. 347, Issue 20, pp. 1557-65, 2002 (PubMed).
Ohara, Granato, Moallem et al.: "Dopaminergic input to GABAergic neurons in the rostral agranular insular cortex of the rat." in: Journal of neurocytology, Vol. 32, Issue 2, pp. 131-41, 2004 (PubMed).
|Applications||Immunohistochemistry (IHC) (1), Immunoprecipitation (IP) (1), Western Blotting (WB) (1)|