Nuclear Factor-KB P65 (NFkBP65) antibody

Details for Product No. ABIN649567
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Antigen
Synonyms c-Rel, C-Rel, Xrel2, c-rel, rel-A, v-rel, xrel, NFKB3, p65, NFkB, zgc:100833
Reactivity
Human
(883), (445), (354), (76), (75), (74), (38), (9), (8), (6), (2), (2), (1), (1), (1)
Host
Rabbit
(827), (67), (6), (6), (1)
Clonality
Monoclonal
Conjugate
Un-conjugated
(24), (19), (15), (11), (10), (10), (10), (10), (10), (10), (10), (10), (10), (10), (1), (1), (1)
Application
Western Blotting (WB)
(678), (352), (335), (187), (142), (128), (100), (51), (21), (19), (18), (12), (7), (5), (2), (1)
Pubmed 1 reference available
Quantity 100 μL
Options
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Catalog No. ABIN649567
450.00 $
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Specificity A synthetic peptide corresponding to residues in human c-Rel was used as an immunogen.
Alternative Name c-Rel
Background C-Rel is a member of the nuclear factor kB (NF-kB) transcription factor family. The NF-kB family of dimeric transcription factors consists of four other mammalian members, RelA (p65), RelB, NF-kB1 (p105/p50) and NFkB2 (p100/p52) and is involved in many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. c-Rel is a proto-oncogene that may play a role in differentiation and lymphopoiesis. c-Rel form different dimer combinations that act as transcriptional activators of repressors (1). Findings indicate that RelA and c-Rel control the development of the epidermis and associated appendages during embryogenesis, they regulate epidermal homeostasis in a postnatal environment through the suppression of innate immune-mediated inflammation (2).
Molecular Weight 78 kDA
Gene ID 7490
UniProt Q04864
Research Area Translation Factors, Phospho-specific antibodies, Protein Modifications, Cancer, Transcription Factors, Signaling, Cell Structure
Application Notes The suggested dilution is: WB: = 1:10000-50000
Comment

Background: c-Rel is a member of the nuclear factor kB (NF-kB) transcription factor family. The NF-kB family of dimeric transcription factors consists of four other mammalian members, RelA (p65), RelB, NF-kB1 (p105/p50) and NFkB2 (p100/p52) and is involved in many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. c-Rel is a proto-oncogene that may play a role in differentiation and lymphopoiesis. c-Rel form different dimer combinations that act as transcriptional activators of repressors (1). Findings indicate that RelA and c-Rel control the development of the epidermis and associated appendages during embryogenesis, they regulate epidermal homeostasis in a postnatal environment through the suppression of innate immune-mediated inflammation (2).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment c-Rel Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Gugasyan, Voss, Varigos et al.: "The transcription factors c-rel and RelA control epidermal development and homeostasis in embryonic and adult skin via distinct mechanisms." in: Molecular and cellular biology, Vol. 24, Issue 13, pp. 5733-45, 2004 (PubMed).

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