V-Rel Reticuloendotheliosis Viral Oncogene Homolog (Avian) (REL) antibody

Antigen: V-Rel Reticuloendotheliosis Viral Oncogene Homolog (Avian) (REL)

Synonyms: C-Rel, rel-A, Xrel2, REL

Clonality: Monoclonal

Host: Rabbit

Reactivity: Human

Conjugate: Un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Certificates: ISO 9001:2008

Catalog no.: ABIN649567

Additional Information

Alternative name: c-Rel

Gene ID: 7490

UniProt: Q04864

Characteristics: Rabbit Monoclonal Antibody

Specificity: A synthetic peptide corresponding to residues in human c-Rel was used as an immunogen.

Molecular Weight: 78 kDA

Comments:

Background: c-Rel is a member of the nuclear factor kB (NF-kB) transcription factor family. The NF-kB family of dimeric transcription factors consists of four other mammalian members, RelA (p65), RelB, NF-kB1 (p105/p50) and NFkB2 (p100/p52) and is involved in many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. c-Rel is a proto-oncogene that may play a role in differentiation and lymphopoiesis. c-Rel form different dimer combinations that act as transcriptional activators of repressors (1). Findings indicate that RelA and c-Rel control the development of the epidermis and associated appendages during embryogenesis, they regulate epidermal homeostasis in a postnatal environment through the suppression of innate immune-mediated inflammation (2).

Application Details

Application Notes: The suggested dilution is: WB: ~~ 1:10000~50000 IP: ~~ 1:10~100

Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Storage: c-Rel Antibody can be stored at -20°C for up to 12 months from time of receipt.

Research Area: Translation Factors, Phospho-specific antibodies, Protein Modifications, Cancer, Transcription Factors, Signaling, Cell Structure

Restrictions: For Research Use only

Publications

Product: Gugasyan, Voss, Varigos et al.: "The transcription factors c-rel and RelA control epidermal development and homeostasis in embryonic and adult skin via distinct mechanisms." in: Molecular and cellular biology, Vol. 24, Issue 13, pp. 5733-45, 2004 (PubMed).