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Details for Product No. ABIN649577

Cullin 3 (CUL3) antibody

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Antigen
Synonyms CUL-3, PHA2E, AI467304, AW146203, mKIAA0617, Cullin-3, CUL-3-A, Cullin-3-A, cul3, cul3a, CUL-3-B, Cullin-3-B, cul3b, wu:fc37e01, CUL3, ATCUL3, ATCUL3A, CUL3A, T24P13.25, cullin 3, cullin 3A
Reactivity
»Alternatives Human, Rat (Rattus)
Host
»Alternatives Rabbit
Clonality Monoclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Flow Cytometry (FACS), Immunoprecipitation (IP)
Pubmed 1 reference available
Catalog no. ABIN649577
Quantity 100 µL
Price
450.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Specificity A synthetic peptide corresponding to residues on the C terminus of human CUL3 was used as an immunogen.
Alternative Name CUL3
Background Cullin-3 (CUL3) is the core component of multiple cullin-RING-based BTB-CUL3-RBX1 (BCR) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. CUL3 is a scaffold protein that may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme (1). CUL3 plays an essential role in both axonal arborization and proper elaboration of dendrites and may require neddylation for its proper function (2).
Synonyms: CUL3, KIAA0617, Cullin-3
Molecular Weight 82/90 kDA
Gene ID 8452
UniProt Q13618
Research Area Ubiquitin-related antibodies, Phospho-specific antibodies, Protein Modifications, Cell Structure
Application Notes The suggested dilution is: WB: ~~ 1:20000~100000 IP: ~~ 1:40 FC: ~~ 1:30
Comment

Background: Cullin-3 (CUL3) is the core component of multiple cullin-RING-based BTB-CUL3-RBX1 (BCR) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. CUL3 is a scaffold protein that may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme (1). CUL3 plays an essential role in both axonal arborization and proper elaboration of dendrites and may require neddylation for its proper function (2).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Storage -20 °C
Storage Comment CUL3 Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications "The universal protein resource (UniProt)." in: Nucleic acids research, Vol. 36, Issue Database issue, pp. D190-5, 2008 (PubMed).

Alternatives for antigen "Cullin 3 (CUL3)", type "Antibodies"
Hosts (56), (6)
Reactivities (62), (30), (20), (12), (12), (12), (12)
Applications (41), (23), (21), (16), (13), (10), (6), (5), (2), (2), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (11), (5), (2), (2), (1), (1), (1), (1), (1)
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