Cullin 3 (CUL3) antibody

Details for Product No. ABIN649577
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Antigen
Synonyms CUL-3, Cullin-3, CUL-3-A, Cullin-3-A, cul3, cul3a, CUL-3-B, Cullin-3-B, cul3b, wu:fc37e01, CUL3, ATCUL3, ATCUL3A, CUL3A, T24P13.25, cullin 3, cullin 3A, PHA2E, AI467304, AW146203, mKIAA0617
Reactivity
Human, Rat (Rattus)
(64), (28), (21), (12), (12), (12), (12)
Host
Rabbit
(58), (6)
Clonality
Monoclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(43), (21), (18), (16), (13), (10), (5), (5), (4), (2)
Pubmed 1 reference available
Quantity 100 μL
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Request Want additional data for this product?

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Catalog No. ABIN649577
450.00 $
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  • +1 404 474 4654
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Specificity A synthetic peptide corresponding to residues on the C terminus of human CUL3 was used as an immunogen.
Alternative Name CUL3
Background Cullin-3 (CUL3) is the core component of multiple cullin-RING-based BTB-CUL3-RBX1 (BCR) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. CUL3 is a scaffold protein that may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme (1). CUL3 plays an essential role in both axonal arborization and proper elaboration of dendrites and may require neddylation for its proper function (2).
Synonyms: CUL3, KIAA0617, Cullin-3
Molecular Weight 82/90 kDA
Gene ID 8452
UniProt Q13618
Research Area Ubiquitin-related antibodies, Phospho-specific antibodies, Protein Modifications, Cell Structure
Application Notes The suggested dilution is: WB: = 1:20000-100000
Comment

Background: Cullin-3 (CUL3) is the core component of multiple cullin-RING-based BTB-CUL3-RBX1 (BCR) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. CUL3 is a scaffold protein that may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme (1). CUL3 plays an essential role in both axonal arborization and proper elaboration of dendrites and may require neddylation for its proper function (2).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment CUL3 Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications "The universal protein resource (UniProt)." in: Nucleic acids research, Vol. 36, Issue Database issue, pp. D190-5, 2008 (PubMed).

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