Add to Basket Bulk discount
Order hotline:
+1 404 474 4654
+1 888 205 9894 (TF)

Cyclin D1 (CCND1) antibody

Antigen

Cyclin D1 (CCND1)
Synonyms
BCL1, PRAD1, U21B31, D11S287E, cD1, Cyl-1, bcl-1, AI327039, DIP1, GCIP, Maid, SECC-8, SSEC-8, AU022347, cb161, cycd1, fb52e01, fc83a12, id:ibd1198, wu:fb52e01, wu:fc83a12, MGC109078, ccnd1b, MGC52909, ... show more
Clonality Monoclonal
Host
Alternatives

Rabbit
Reactivity
Alternatives

Human, Rat (Rattus)
Conjugate
Alternatives Un-conjugated
Application
Alternatives Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP)
5 references available
Certificates ISO 9001:2008
Catalog no. ABIN649583
Quantity 100ul  (Variants)
Price 450.00 $   Plus shipping costs $45.00
Bulk discount
Shipping to
Availability Will be delivered in 2 to 3 Business Days

Additional Information
Application Details Publications Alternatives Variants back to top

Alternative name Cyclin D1
Gene ID 595
UniProt P24385
Description Other names: CCND1, BCL1, PRAD1, G1/S-specific cyclin-D1, PRAD1 oncogene,BCL-1 oncogene
Characteristics Rabbit Monoclonal Antibody
Specificity A synthetic peptide corresponding to residues near the C-terminus of human Cyclin D1 was used as an immunogen.
Molecular Weight 36 kDA
Comments

Background: Cyclin D1 belongs to the Cyclin D family. Cyclin D1 is required for the cell cycle G1/S transition (1). Cyclin D1 forms a serine/threonine kinase holoenzyme complex with and functions as a regulatory subunit of CDK4 or CDK6. Cyclin D1 also phosphorylates and inactivates the retinoblastoma protein and promotes progression through the G1/S phase (2-3). Amplification or overexpression of cyclin D1 plays a pivotal role in the development of various human cancers including parathyroid adenoma, breast cancer, colon cancer, lymphoma, melanoma, and prostate cancer (4). Over-expression of cyclin D1 is known to correlate with the early onset of cancer and risk of tumor progression and metastasis (5). Cyclin D1 also associates with, and regulates the activity of transcription factors, coactivators and corepressors that govern histone acetylation and chromatin remodeling proteins (6-7)
Synonyms BCL1, PRAD1, U21B31, D11S287E, cD1, Cyl-1, bcl-1, AI327039, DIP1, GCIP, Maid, SECC-8, SSEC-8, AU022347, cb161, cycd1, fb52e01, fc83a12, id:ibd1198, wu:fb52e01, wu:fc83a12, MGC109078, ccnd1b, MGC52909, MGC132138, ccnd1, MGC53090, bcl1, prad1, u21b31, MGC69515, d11s287e, CCND1, ccndbp1, MGC137744, ZHM, CCNDBP1, MGC133757, DKFZp468E2216, DKFZp469C1216, DKFZp469H0317

Application Details
Publications Alternatives Variants back to top

Application Notes The suggested dilution is: WB: ~~ 1:10000 IP: ~~ 1:40 ICC: ~~ 1:100 IHC: ~~ 1:100
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Storage Cyclin D1 Antibody can be stored at -20°C for up to 12 months from time of receipt.
Research Area Ubiquitin-related antibodies, Phospho-specific antibodies, Protein Modifications, Cancer, Cell Cycle, Signaling, Chromatin, Cell Structure
Restrictions For Research Use only

Publications
Application Details Alternatives Variants back to top

Product Inaba, Matsushime, Valentine et al.: "Genomic organization, chromosomal localization, and independent expression of human cyclin D genes." in: Genomics, Vol. 13, Issue 3, pp. 565-74, 1992 (PubMed).

Motokura, Arnold: "PRAD1/cyclin D1 proto-oncogene: genomic organization, 5' DNA sequence, and sequence of a tumor-specific rearrangement breakpoint." in: Genes, chromosomes & cancer, Vol. 7, Issue 2, pp. 89-95, 1993 (PubMed).

Baldin, Lukas, Marcote et al.: "Cyclin D1 is a nuclear protein required for cell cycle progression in G1." in: Genes & development, Vol. 7, Issue 5, pp. 812-21, 1993 (PubMed).

Neumeister, Pixley, Xiong et al.: "Cyclin D1 governs adhesion and motility of macrophages." in: Molecular biology of the cell, Vol. 14, Issue 5, pp. 2005-15, 2003 (PubMed).

Wang, Li, Fu et al.: "Signal transduction mediated by cyclin D1: from mitogens to cell proliferation: a molecular target with therapeutic potential." in: Cancer treatment and research, Vol. 119, pp. 217-37, 2004 (PubMed).

Alternatives
Application Details Publications Variants back to top

Alternatives for antigen "Cyclin D1 (CCND1)", type "Antibodies"
Hosts Rabbit (143), Mouse (61)
Reactivities Human (181), Mouse (Murine) (65), Rat (Rattus) (65), Chicken (6), Dog (Canine) (6), Cow (Bovine) (4), Monkey (4), Rabbit (3), Guinea Pig (2), Xenopus laevis (2), Cat (Feline) (1), Fruit Fly (Drosophila melanogaster) (1), Orang-Utan (1), Zebrafish (1)
Applications Western Blotting (WB) (145), ELISA (64), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (59), Immunoprecipitation (IP) (54), Immunofluorescence (IF) (43), Immunohistochemistry (IHC) (31), Flow Cytometry (FACS) (21), Immunocytochemistry (ICC) (18), Immunohistochemistry (Frozen Sections) (IHC (fro)) (17), Functional Studies (Func) (13), Immunohistochemistry (Fixed) (IHC (fx)) (7), Blocking Antibody (Inhibition) (5), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (5), Dot Blot (DB) (1), Dot Blot (Dot) (1), Immunoelectron Microscopy (IEM) (1), Neutralization (Neut) (1)
Conjugates Biotin (9), FITC (7), Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1)
Epitopes pThr286 (19), C-Term (18), N-Term (9), Internal Region (8), C-Term,AA 211-241 (2), Center (2), Ser90 (2), AA 1-295 (1), AA 250-300 (1), C-Term,AA 273-295 (1), Internal Region,AA 147-175 (1), Internal Region,AA 154-183 (1), Tyr226 (1), pThr288 (1)