Cyclin D1 (CCND1) antibody

Details for Product No. ABIN649583
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Antigen
Synonyms
ccnd1b, prad1, bcl1, d11s287e, u21b31, ccndbp1, ccnd1, ZHM, CCND1, BCL1, D11S287E, PRAD1, U21B31, AI327039, CycD1, Cyl-1, bcl-1, cD1, ccnd1a, cb161, cycd1, etID37810.7, fb52e01, fc45c08, fc83a12, id:i ... show more
ccnd1b, prad1, bcl1, d11s287e, u21b31, ccndbp1, ccnd1, ZHM, CCND1, BCL1, D11S287E, PRAD1, U21B31, AI327039, CycD1, Cyl-1, bcl-1, cD1, ccnd1a, cb161, cycd1, etID37810.7, fb52e01, fc45c08, fc83a12, id:ibd1198, wu:fb52e01, wu:fc45c08, wu:fc83a12 show less
Reactivity
Human, Rat (Rattus)
(259), (97), (94), (28), (16), (9), (7), (2), (2), (1), (1), (1), (1), (1)
Host
Rabbit
(224), (73), (1)
Clonality
Monoclonal
Conjugate
Un-conjugated
(11), (9), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(240), (87), (82), (54), (54), (39), (34), (33), (20), (19), (11), (3), (3), (3), (2), (1)
Pubmed 5 references available
Quantity 100 µL
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Catalog No. ABIN649583
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Specificity A synthetic peptide corresponding to residues near the C-terminus of human Cyclin D1 was used as an immunogen.
Alternative Name Cyclin D1
Background Cyclin D1 belongs to the Cyclin D family. Cyclin D1 is required for the cell cycle G1/S transition (1). Cyclin D1 forms a serine/threonine kinase holoenzyme complex with and functions as a regulatory subunit of CDK4 or CDK6. Cyclin D1 also phosphorylates and inactivates the retinoblastoma protein and promotes progression through the G1/S phase (2-3). Amplification or overexpression of cyclin D1 plays a pivotal role in the development of various human cancers including parathyroid adenoma, breast cancer, colon cancer, lymphoma, melanoma, and prostate cancer (4). Over-expression of cyclin D1 is known to correlate with the early onset of cancer and risk of tumor progression and metastasis (5). Cyclin D1 also associates with, and regulates the activity of transcription factors, coactivators and corepressors that govern histone acetylation and chromatin remodeling proteins (6-7)
Synonyms: CCND1, BCL1, PRAD1, G1/S-specific cyclin-D1, PRAD1 oncogene,BCL-1 oncogene
Molecular Weight 36 kDA
Gene ID 595
UniProt P24385
Research Area Ubiquitin-related antibodies, Phospho-specific antibodies, Protein Modifications, Cancer, Cell Cycle, Signaling, Chromatin, Cell Structure
Application Notes IHC: = 1:100, WB: = 1:10000
Comment

Background: Cyclin D1 belongs to the Cyclin D family. Cyclin D1 is required for the cell cycle G1/S transition (1). Cyclin D1 forms a serine/threonine kinase holoenzyme complex with and functions as a regulatory subunit of CDK4 or CDK6. Cyclin D1 also phosphorylates and inactivates the retinoblastoma protein and promotes progression through the G1/S phase (2-3). Amplification or overexpression of cyclin D1 plays a pivotal role in the development of various human cancers including parathyroid adenoma, breast cancer, colon cancer, lymphoma, melanoma, and prostate cancer (4). Over-expression of cyclin D1 is known to correlate with the early onset of cancer and risk of tumor progression and metastasis (5). Cyclin D1 also associates with, and regulates the activity of transcription factors, coactivators and corepressors that govern histone acetylation and chromatin remodeling proteins (6-7)

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Cyclin D1 Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Inaba, Matsushime, Valentine et al.: "Genomic organization, chromosomal localization, and independent expression of human cyclin D genes." in: Genomics, Vol. 13, Issue 3, pp. 565-74, 1992 (PubMed).

Motokura, Arnold: "PRAD1/cyclin D1 proto-oncogene: genomic organization, 5' DNA sequence, and sequence of a tumor-specific rearrangement breakpoint." in: Genes, chromosomes & cancer, Vol. 7, Issue 2, pp. 89-95, 1993 (PubMed).

Baldin, Lukas, Marcote et al.: "Cyclin D1 is a nuclear protein required for cell cycle progression in G1." in: Genes & development, Vol. 7, Issue 5, pp. 812-21, 1993 (PubMed).

Neumeister, Pixley, Xiong et al.: "Cyclin D1 governs adhesion and motility of macrophages." in: Molecular biology of the cell, Vol. 14, Issue 5, pp. 2005-15, 2003 (PubMed).

Wang, Li, Fu et al.: "Signal transduction mediated by cyclin D1: from mitogens to cell proliferation: a molecular target with therapeutic potential." in: Cancer treatment and research, Vol. 119, pp. 217-37, 2004 (PubMed).

Validation Images
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