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Cyclin D1 (CCND1) antibody
Human, Rat (Rattus)
Alternatives Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP)
|5 references available|
|Price||450.00 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Alternative name||Cyclin D1|
|Description||Other names: CCND1, BCL1, PRAD1, G1/S-specific cyclin-D1, PRAD1 oncogene,BCL-1 oncogene|
|Characteristics||Rabbit Monoclonal Antibody|
|Specificity||A synthetic peptide corresponding to residues near the C-terminus of human Cyclin D1 was used as an immunogen.|
|Molecular Weight||36 kDA|
Background: Cyclin D1 belongs to the Cyclin D family. Cyclin D1 is required for the cell cycle G1/S transition (1). Cyclin D1 forms a serine/threonine kinase holoenzyme complex with and functions as a regulatory subunit of CDK4 or CDK6. Cyclin D1 also phosphorylates and inactivates the retinoblastoma protein and promotes progression through the G1/S phase (2-3). Amplification or overexpression of cyclin D1 plays a pivotal role in the development of various human cancers including parathyroid adenoma, breast cancer, colon cancer, lymphoma, melanoma, and prostate cancer (4). Over-expression of cyclin D1 is known to correlate with the early onset of cancer and risk of tumor progression and metastasis (5). Cyclin D1 also associates with, and regulates the activity of transcription factors, coactivators and corepressors that govern histone acetylation and chromatin remodeling proteins (6-7)
|Synonyms||BCL1, PRAD1, U21B31, D11S287E, cD1, Cyl-1, bcl-1, AI327039, DIP1, GCIP, Maid, SECC-8, SSEC-8, AU022347, cb161, cycd1, fb52e01, fc83a12, id:ibd1198, wu:fb52e01, wu:fc83a12, MGC109078, ccnd1b, MGC52909, MGC132138, ccnd1, MGC53090, bcl1, prad1, u21b31, MGC69515, d11s287e, CCND1, ccndbp1, MGC137744, ZHM, CCNDBP1, MGC133757, DKFZp468E2216, DKFZp469C1216, DKFZp469H0317|
|Application Notes||The suggested dilution is: WB: ~~ 1:10000 IP: ~~ 1:40 ICC: ~~ 1:100 IHC: ~~ 1:100|
|Buffer||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Cyclin D1 Antibody can be stored at -20°C for up to 12 months from time of receipt.|
|Research Area||Ubiquitin-related antibodies, Phospho-specific antibodies, Protein Modifications, Cancer, Cell Cycle, Signaling, Chromatin, Cell Structure|
|Restrictions||For Research Use only|
Inaba, Matsushime, Valentine et al.: "Genomic organization, chromosomal localization, and independent expression of human cyclin D genes." in: Genomics, Vol. 13, Issue 3, pp. 565-74, 1992 (PubMed).
Motokura, Arnold: "PRAD1/cyclin D1 proto-oncogene: genomic organization, 5' DNA sequence, and sequence of a tumor-specific rearrangement breakpoint." in: Genes, chromosomes & cancer, Vol. 7, Issue 2, pp. 89-95, 1993 (PubMed).
Baldin, Lukas, Marcote et al.: "Cyclin D1 is a nuclear protein required for cell cycle progression in G1." in: Genes & development, Vol. 7, Issue 5, pp. 812-21, 1993 (PubMed).
Neumeister, Pixley, Xiong et al.: "Cyclin D1 governs adhesion and motility of macrophages." in: Molecular biology of the cell, Vol. 14, Issue 5, pp. 2005-15, 2003 (PubMed).
Wang, Li, Fu et al.: "Signal transduction mediated by cyclin D1: from mitogens to cell proliferation: a molecular target with therapeutic potential." in: Cancer treatment and research, Vol. 119, pp. 217-37, 2004 (PubMed).