Did you know that you can buy products from over 140 different suppliers from us?

Cyclin E2 (CCNE2) (C-Term) antibody

Details for Product No. ABIN649588
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Antigen
Synonyms cyce2, CYCE2, ccne2, MGC53684, MGC132360, cb165, sb:cb165, zgc:86724, CCNE2
Epitope
C-Term
(16), (8), (8), (3), (1), (1), (1)
Reactivity
Human, Rat (Rattus)
(63), (31), (17), (13), (12), (7), (1)
Host
Rabbit
(69), (4), (1)
Clonality
Monoclonal
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application
Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
(49), (27), (20), (13), (12), (8), (4), (1), (1)
Pubmed 3 references available
Quantity 100 µL
Options
Shipping to United States (Change)
Availability Will be delivered in 2 to 3 Business Days
Catalog No. ABIN649588
450.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Specificity A synthetic peptide corresponding to residues in C-terminus of human Cyclin E2 was used as immunogen. Predicted to cross-react with bovine, based on sequence homology.
Alternative Name Cyclin E2
Background Cyclin E2 is a member of the cyclin E family that can associate with and activate Cdk2. Expression of cyclin E2 is essential for the control of the cell cycle at the late G1 and early S phase, and this protein may regulate distinct rate-limiting pathway(s) during this phase (1). Cyclin E2 specifically interacts with Cdk inhibitors of the CIP/KIP family and activates both Cdk2 and Cdk3. Expression of the viral E6 oncoprotein in normal human fibroblasts increases levels of cyclin E2, but not cyclin E1, while expression of the E7 oncoprotein upregulates both (2). Abnormally high levels of cyclin E expression have frequently been observed in human cancers (3).
Synonyms: CCNE2, G1/S-specific cyclin-E2
Molecular Weight 50 kDA
Gene ID 9134
UniProt O96020
Research Area Phospho-specific antibodies, Protein Modifications, Cell Cycle, Cell Structure
Application Notes The suggested dilution is: WB: = 1:5000-10000 , IHC: = 1:50
Comment

Background: Cyclin E2 is a member of the cyclin E family that can associate with and activate Cdk2. Expression of cyclin E2 is essential for the control of the cell cycle at the late G1 and early S phase, and this protein may regulate distinct rate-limiting pathway(s) during this phase (1). Cyclin E2 specifically interacts with Cdk inhibitors of the CIP/KIP family and activates both Cdk2 and Cdk3. Expression of the viral E6 oncoprotein in normal human fibroblasts increases levels of cyclin E2, but not cyclin E1, while expression of the E7 oncoprotein upregulates both (2). Abnormally high levels of cyclin E expression have frequently been observed in human cancers (3).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Cyclin E2 Antibody (C-term) can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Lauper, Beck, Cariou et al.: "Cyclin E2: a novel CDK2 partner in the late G1 and S phases of the mammalian cell cycle." in: Oncogene, Vol. 17, Issue 20, pp. 2637-43, 1998 (PubMed).

Zariwala, Liu, Xiong: "Cyclin E2, a novel human G1 cyclin and activating partner of CDK2 and CDK3, is induced by viral oncoproteins." in: Oncogene, Vol. 17, Issue 21, pp. 2787-98, 1998 (PubMed).

Gudas, Payton, Thukral et al.: "Cyclin E2, a novel G1 cyclin that binds Cdk2 and is aberrantly expressed in human cancers." in: Molecular and cellular biology, Vol. 19, Issue 1, pp. 612-22, 1999 (PubMed).

Hosts (69), (4), (1)
Reactivities (63), (31), (17), (13), (12), (7), (1)
Applications (49), (27), (20), (13), (12), (8), (4), (1), (1)
Conjugates (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (16), (8), (8), (3), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN649588
450.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
back to top