Cytochrome C, Somatic (CYCS) antibody

Details for Product No. ABIN649595
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Antigen
Synonyms
cyct, cyc, hcs, CYCS, cycs, CYC, CG13263, Cyt C, Cyt c, Cyt-c1, CytC-1, CytC1, Cytc, Cytc-d, DC3, Dmel\\CG13263, bln, bs30f07.y1, cyt c, cyt c-d, cyt-c-d, cyt.c, cytochrome c, dc3, ms(2)04445, pDMc02, ... show more
cyct, cyc, hcs, CYCS, cycs, CYC, CG13263, Cyt C, Cyt c, Cyt-c1, CytC-1, CytC1, Cytc, Cytc-d, DC3, Dmel\\CG13263, bln, bs30f07.y1, cyt c, cyt c-d, cyt-c-d, cyt.c, cytochrome c, dc3, ms(2)04445, pDMc02, CG17903, Cyt-c2, CytC-2, Cytc-p, DC4, DMc01, Dmel\\CG17903, cyt c-p, cyt-c-p, cyt-c2, dc4, pDMc01, HCS, THC4, cytc, CYCSA, wu:fk52b01, zgc:86706, ENSMUSG00000058927 show less
Reactivity
Human, Rat (Rattus)
(116), (68), (64), (31), (19), (15), (13), (12), (12), (7), (5), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Host
Rabbit
(106), (61), (7), (3)
Clonality
Monoclonal
Conjugate
Un-conjugated
(11), (4), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(130), (54), (33), (33), (33), (24), (17), (13), (11), (10), (6), (5), (4), (3), (3), (2), (2), (2), (2), (1), (1), (1)
Pubmed 2 references available
Quantity 100 µL
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Catalog No. ABIN649595
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Specificity A synthetic peptide corresponding to residues near the N-terminus of human Cytochrome C was used as an immunogen.
Alternative Name Cytochrome C
Background Cytochrome c is located in the mitochondria of all aerobic cells and is involved in the electron transport system that functions in oxidative phosphorylation. It accepts electrons from cytochrome b and transfers them to cytochrome oxidase. In the process, the iron of the heme group, which is identical to that of hemoglobin and myoglobin, shifts from the ferrous to the ferric state (1). Recent progress in studies on apoptosis has revealed that cytochrome c is a pro-apoptotic factor. It is released from its places on the outer surface of the inner mitochondrial membrane at early steps of apoptosis and, combining with some cytosolic proteins, activates conversion of the latent apoptosis-promoting protease pro-caspase-9 to its active form. Cytochrome c release can be initiated by the pro-apoptotic protein Bax. This process is blocked by the anti-apoptotic proteins Bcl-2 and Bcl-xL (2). Also, differences in amino acid composition of cytochrome c have also been used as markers of biochemical evolution.
Molecular Weight 14 kDA
Gene ID 54205
Research Area Apoptosis/Necrosis, Signaling, Cell Signaling, Protein Modifications, Metabolism, Cell Structure
Application Notes IHC: = 1:100, WB: = 1:1000-10000
Comment

Background: Cytochrome c is located in the mitochondria of all aerobic cells and is involved in the electron transport system that functions in oxidative phosphorylation. It accepts electrons from cytochrome b and transfers them to cytochrome oxidase. In the process, the iron of the heme group, which is identical to that of hemoglobin and myoglobin, shifts from the ferrous to the ferric state (1). Recent progress in studies on apoptosis has revealed that cytochrome c is a pro-apoptotic factor. It is released from its places on the outer surface of the inner mitochondrial membrane at early steps of apoptosis and, combining with some cytosolic proteins, activates conversion of the latent apoptosis-promoting protease pro-caspase-9 to its active form. Cytochrome c release can be initiated by the pro-apoptotic protein Bax. This process is blocked by the anti-apoptotic proteins Bcl-2 and Bcl-xL (2). Also, differences in amino acid composition of cytochrome c have also been used as markers of biochemical evolution.

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Cytochrome C Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Skulachev: "Cytochrome c in the apoptotic and antioxidant cascades." in: FEBS letters, Vol. 423, Issue 3, pp. 275-80, 1998 (PubMed).

Wojtczak: "[Two faces of cytochrome c]." in: Postepy biochemii, Vol. 52, Issue 2, pp. 122-8, 2006 (PubMed).

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