Keratin 13 (KRT13) antibody

Antigen: Keratin 13 (KRT13)

Synonyms: K13, CK13, MGC3781, MGC161462, Krt1-13, Krt-1.13, Ka13, k13, ck13, MGC84388, MGC115054, krt13, KRT15

Clonality: Monoclonal

Host: Rabbit

Reactivity: Human

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Certificates: ISO 9001:2008

Catalog no.: ABIN649599

Additional Information

Alternative name: Cytokeratin-13

Gene ID: 23600

UniProt: P13646

Characteristics: Rabbit Monoclonal Antibody

Specificity: A synthetic peptide corresponding to residues in human CK13 was used as an immunogen.

Molecular Weight: 50 kDA

Comments:

Background: Keratins are a family of highly homologous proteins expressed as pairs of acidic and basic forms which make intermediate filaments in epithelial cells. Keratin 13 (CK13) is the major acidic keratin, which together with K4, its basic partner, is expressed in the suprabasal layers of non-cornified stratified epithelia (1). White sponge nevus (WSN) is a rare autosomal dominant disorder of non-cornifying squamous epithelial differentiation that presents clinically as bilateral white, soft, thick plaques of the oral mucosa. In WSN, the restriction of lesions to mucosal epithelia and the suprabasal cell histopathology parallels the tissue-specific expression of keratins 4 and 13 in the differentiating cell layers (2).

Application Details

Application Notes: The suggested dilution is: WB: ~~ 1:2000 ICC: ~~ 1:50~100 IHC: ~~ 1:100~250

Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Storage: Cytokeratin-13 Antibody can be stored at -20°C for up to 12 months from time of receipt.

Research Area: Phospho-specific antibodies, Protein Modifications, Cell Structure

Restrictions: For Research Use only

Publications

Product: Richard, De Laurenzi, Didona et al.: "Keratin 13 point mutation underlies the hereditary mucosal epithelial disorder white sponge nevus." in: Nature genetics, Vol. 11, Issue 4, pp. 453-5, 1996 (PubMed).

Waseem, Alam, Dogan et al.: "Isolation, sequence and expression of the gene encoding human keratin 13." in: Gene, Vol. 215, Issue 2, pp. 269-79, 1998 (PubMed).