Keratin 13 (KRT13) antibody

Details for Product No. ABIN649599
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Antigen
Synonyms krt13, CK13, K13, Ka13, Krt-1.13, Krt1-13, ck13, k13
Reactivity
Human
(101), (27), (26), (16), (12), (3), (3), (3), (1), (1), (1)
Host
Rabbit
(55), (42), (7), (3)
Clonality
Monoclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(80), (48), (25), (25), (23), (22), (13), (10), (8), (4), (1)
Pubmed 2 references available
Quantity 100 µL
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Catalog No. ABIN649599
450.00 $
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Specificity A synthetic peptide corresponding to residues in human CK13 was used as an immunogen.
Alternative Name Cytokeratin-13
Background Keratins are a family of highly homologous proteins expressed as pairs of acidic and basic forms which make intermediate filaments in epithelial cells. Keratin 13 (CK13) is the major acidic keratin, which together with K4, its basic partner, is expressed in the suprabasal layers of non-cornified stratified epithelia (1). White sponge nevus (WSN) is a rare autosomal dominant disorder of non-cornifying squamous epithelial differentiation that presents clinically as bilateral white, soft, thick plaques of the oral mucosa. In WSN, the restriction of lesions to mucosal epithelia and the suprabasal cell histopathology parallels the tissue-specific expression of keratins 4 and 13 in the differentiating cell layers (2).
Molecular Weight 50 kDA
Gene ID 23600
UniProt P13646
Research Area Phospho-specific antibodies, Protein Modifications, Cell Structure
Application Notes The suggested dilution is: WB: = 1:2000 , IHC: = 1:100-250
Comment

Background: Keratins are a family of highly homologous proteins expressed as pairs of acidic and basic forms which make intermediate filaments in epithelial cells. Keratin 13 (CK13) is the major acidic keratin, which together with K4, its basic partner, is expressed in the suprabasal layers of non-cornified stratified epithelia (1). White sponge nevus (WSN) is a rare autosomal dominant disorder of non-cornifying squamous epithelial differentiation that presents clinically as bilateral white, soft, thick plaques of the oral mucosa. In WSN, the restriction of lesions to mucosal epithelia and the suprabasal cell histopathology parallels the tissue-specific expression of keratins 4 and 13 in the differentiating cell layers (2).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Cytokeratin-13 Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Richard, De Laurenzi, Didona et al.: "Keratin 13 point mutation underlies the hereditary mucosal epithelial disorder white sponge nevus." in: Nature genetics, Vol. 11, Issue 4, pp. 453-5, 1996 (PubMed).

Waseem, Alam, Dogan et al.: "Isolation, sequence and expression of the gene encoding human keratin 13." in: Gene, Vol. 215, Issue 2, pp. 269-79, 1998 (PubMed).

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