Keratin 7 (KRT7) antibody

Details for Product No. ABIN649622
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Antigen
Synonyms CK7, K2C7, K7, SCL, D15Wsu77e, Krt2-7, KRT7
Reactivity
Human
(185), (46), (42), (8), (7), (7), (4), (4), (4), (3), (1), (1), (1)
Host
Rabbit
(107), (101), (3)
Clonality
Monoclonal
Conjugate
Un-conjugated
(10), (7), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
(146), (92), (55), (50), (49), (40), (33), (31), (20), (10), (10), (3), (2), (1)
Pubmed 3 references available
Quantity 100 μL
Options
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Catalog No. ABIN649622
450.00 $
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Specificity A synthetic peptide corresponding to residues near the N-term of human CK-7 was used as an immunogen.
Alternative Name Cytokeratin-7
Background Keratins are cytoplasmic intermediate filament proteins expressed by epithelial cells. Keratin 7 (CK7) is expressed in a wide range of epithelial structures in humans. The expression pattern in mice is similar to the reported human distribution, with substantial expression observed in lung, bladder, mesothelium, hair follicle, and ductal structures (1). Protein expression levels of CK7 appear significantly higher in chromophobe RCC compared to oncocytoma (p <
Synonyms: KRT7, SCL, Keratin, type II cytoskeletal 7, Sarcolectin
Molecular Weight 55 kDA
Gene ID 3855
UniProt P08729
Research Area Signaling, Phospho-specific antibodies, Protein Modifications, Cell Structure
Application Notes The suggested dilution is: WB: = 1:1000-5000, IHC: = 1:100-250
Comment

Background: Keratins are cytoplasmic intermediate filament proteins expressed by epithelial cells. Keratin 7 (CK7) is expressed in a wide range of epithelial structures in humans. The expression pattern in mice is similar to the reported human distribution, with substantial expression observed in lung, bladder, mesothelium, hair follicle, and ductal structures (1). Protein expression levels of CK7 appear significantly higher in chromophobe RCC compared to oncocytoma (p <

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Cytokeratin-7 Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Smith, Porter, Corden et al.: "Cloning of human, murine, and marsupial keratin 7 and a survey of K7 expression in the mouse." in: Biochemical and biophysical research communications, Vol. 297, Issue 4, pp. 818-27, 2002 (PubMed).

Coons, Estrada, Gamez et al.: "Cytokeratin CK 7 and CK 20 expression in pituitary adenomas." in: Endocrine pathology, Vol. 16, Issue 3, pp. 201-10, 2005 (PubMed).

Adley, Papavero, Sugimura et al.: "Diagnostic value of cytokeratin 7 and parvalbumin in differentiating chromophobe renal cell carcinoma from renal oncocytoma." in: Analytical and quantitative cytology and histology / the International Academy of Cytology [and] American Society of Cytology, Vol. 28, Issue 4, pp. 228-36, 2006 (PubMed).

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