Disabled Homolog 1 (Drosophila) (DAB1) antibody

Details for Product No. ABIN649631
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Antigen
Synonyms scm, scr, yot, AI956902, scrambler, C630028C02Rik, disabled-1, LOC100232823, si:dkey-242m13.1, DAB1
Reactivity
Rat (Rattus)
(111), (102), (94), (60), (60), (48), (48)
Host
Rabbit
(113), (6), (3), (2)
Clonality
Monoclonal
Conjugate
Un-conjugated
(5), (5), (5), (5), (5), (5), (5), (5), (5), (5), (5)
Application
Western Blotting (WB)
(67), (50), (36), (24), (15), (8), (8), (7), (2), (2)
Pubmed 1 reference available
Catalog no. ABIN649631
Quantity 100 µL
Price
392.86 $   Plus shipping costs $45.00
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Specificity A synthetic peptide corresponding to residues surrounding serine 491 of human Dab1 was used as an immunogen.
Alternative Name Dab1
Background Disabled-1 (Dab1) regulates laminar organization in the developing mammalian brain. Although mutation of the disabled-1 gene in scrambler mice results in abnormalities in neuronal positioning, migratory behavior linked to Dab1 signaling is not completely understood. Results outline the molecular mechanism by which Dab1 signaling controls the adhesive property of neurons to radial glia, thereby maintaining proper neuronal positioning during corticogenesis (1). Reelin is a large extracellular protein secreted by pioneer neurons that coordinates cell positioning during neurodevelopment. Dab1 is a phosphoprotein that appears to function as an intracellular adaptor in protein kinase pathways. Expression analysis indicates that mdab1 is expressed in neuronal populations exposed to Reelin. The similar phenotypes of reeler, scrambler, yotari and mdab1 null mice indicate that Reelin and Dab1 function as signaling molecules that regulate cell positioning in the developing brain (2). Layering of neurons in the cerebral cortex and cerebellum requires Reelin, Dab1 as well as two other proteins, cell surface receptors termed very low density lipoprotein receptor (VLDLR) and apolipoprotein E receptor 2 (ApoER2) (3).
Molecular Weight 80 kDA
Gene ID 1600
UniProt O75553
Research Area Phospho-specific antibodies, Protein Modifications, Cell Cycle, Neurology, Cell Structure
Application Notes The suggested dilution is: WB: = 1:1000-2000
Comment

Background: Disabled-1 (Dab1) regulates laminar organization in the developing mammalian brain. Although mutation of the disabled-1 gene in scrambler mice results in abnormalities in neuronal positioning, migratory behavior linked to Dab1 signaling is not completely understood. Results outline the molecular mechanism by which Dab1 signaling controls the adhesive property of neurons to radial glia, thereby maintaining proper neuronal positioning during corticogenesis (1). Reelin is a large extracellular protein secreted by pioneer neurons that coordinates cell positioning during neurodevelopment. Dab1 is a phosphoprotein that appears to function as an intracellular adaptor in protein kinase pathways. Expression analysis indicates that mdab1 is expressed in neuronal populations exposed to Reelin. The similar phenotypes of reeler, scrambler, yotari and mdab1 null mice indicate that Reelin and Dab1 function as signaling molecules that regulate cell positioning in the developing brain (2). Layering of neurons in the cerebral cortex and cerebellum requires Reelin, Dab1 as well as two other proteins, cell surface receptors termed very low density lipoprotein receptor (VLDLR) and apolipoprotein E receptor 2 (ApoER2) (3).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Background publications Trommsdorff, Gotthardt, Hiesberger et al.: "Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2." in: Cell, Vol. 97, Issue 6, pp. 689-701, 1999 (PubMed).

Hosts (113), (6), (3), (2)
Reactivities (111), (102), (94), (60), (60), (48), (48)
Applications (67), (50), (36), (24), (15), (8), (8), (7), (2), (2)
Conjugates (5), (5), (5), (5), (5), (5), (5), (5), (5), (5), (5)
Epitopes (20), (14), (14), (13), (7), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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