Desmin (DES) antibody

Details for Product No. ABIN649642
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Antigen
Synonyms DES, des-b, MGC80853, des, csm1, csm2, desm, cmd1i, MGC75911, LOC100220724, desmin, cb290, fb59a12, wu:fb59a12, zgc:109859, CSM1, CSM2, LGMD2R, wu:fc11d08, zgc:154009, des-a, MGC52614
Reactivity
Human, Rat (Rattus)
(229), (87), (86), (42), (30), (26), (19), (7), (6), (3), (3), (1), (1)
Host
Rabbit
(160), (84), (8)
Clonality
Monoclonal
Conjugate
Un-conjugated
(5), (5), (5), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(173), (109), (82), (67), (46), (30), (20), (20), (14), (10), (3), (3), (1), (1), (1)
Pubmed 3 references available
Quantity 100 μL
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Availability Will be delivered in 2 to 3 Business Days
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Catalog No. ABIN649642
450.00 $
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  • +1 404 474 4654
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Specificity A synthetic peptide corresponding to C-terminus of human Desmin was used as immunogen. Predicted to cross-react with rat, bovine and pig, based on sequence homology.
Alternative Name Desmin
Background Desmin are class-III intermediate filaments found in muscle cells, and are expressed during the formation of muscle cells or fibers. Cytoskeletal intermediate filaments (IFs) are constructed from two-chain alpha-helical coiled-coil molecules arranged on an imperfect helical lattice (1,2). In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures. Desmin mutations have been linked to familial cardiac and skeletal myopathy (3,4).
Synonyms: DES, Desmin
Research Area Neurology, Cell Structure
Comment

Background: Desmin are class-III intermediate filaments found in muscle cells, and are expressed during the formation of muscle cells or fibers. Cytoskeletal intermediate filaments (IFs) are constructed from two-chain alpha-helical coiled-coil molecules arranged on an imperfect helical lattice (1,2). In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures. Desmin mutations have been linked to familial cardiac and skeletal myopathy (3,4).

Restrictions For Research Use only
Format Liquid
Background publications Li, Paulin: "High level desmin expression depends on a muscle-specific enhancer." in: The Journal of biological chemistry, Vol. 266, Issue 10, pp. 6562-70, 1991 (PubMed).

Li, Lilienbaum, Butler-Browne et al.: "Human desmin-coding gene: complete nucleotide sequence, characterization and regulation of expression during myogenesis and development." in: Gene, Vol. 78, Issue 2, pp. 243-54, 1989 (PubMed).

Goldfarb, Park, Cervenáková et al.: "Missense mutations in desmin associated with familial cardiac and skeletal myopathy." in: Nature genetics, Vol. 19, Issue 4, pp. 402-3, 1998 (PubMed).

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