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Desmin (DES) antibody
Human, Rat (Rattus)
Alternatives Western Blotting (WB), Immunohistochemistry (IHC)
|3 references available|
|Price||450.00 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Description||Other names: DES, Desmin|
|Characteristics||Rabbit Monoclonal Antibody|
|Specificity||A synthetic peptide corresponding to C-terminus of human Desmin was used as immunogen. Predicted to cross-react with rat, bovine and pig, based on sequence homology.|
Background: Desmin are class-III intermediate filaments found in muscle cells, and are expressed during the formation of muscle cells or fibers. Cytoskeletal intermediate filaments (IFs) are constructed from two-chain alpha-helical coiled-coil molecules arranged on an imperfect helical lattice (1,2). In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures. Desmin mutations have been linked to familial cardiac and skeletal myopathy (3,4).
|Synonyms||DES, des-a, MGC52614, des-b, MGC80853, CSM1, CSM2, CMD1I, FLJ12025, FLJ39719, FLJ41013, FLJ41793, des, csm1, csm2, desm, cmd1i, MGC75911, LOC395906, LOC100220724, desmin, cb290, fb59a12, MGC109859, wu:fb59a12, zgc:109859, MGC154009, wu:fc11d08|
|Research Area||Neurology, Cell Structure|
|Restrictions||For Research Use only|
Li, Paulin: "High level desmin expression depends on a muscle-specific enhancer." in: The Journal of biological chemistry, Vol. 266, Issue 10, pp. 6562-70, 1991 (PubMed).
Li, Lilienbaum, Butler-Browne et al.: "Human desmin-coding gene: complete nucleotide sequence, characterization and regulation of expression during myogenesis and development." in: Gene, Vol. 78, Issue 2, pp. 243-54, 1989 (PubMed).
Goldfarb, Park, Cervenáková et al.: "Missense mutations in desmin associated with familial cardiac and skeletal myopathy." in: Nature genetics, Vol. 19, Issue 4, pp. 402-3, 1998 (PubMed).