Parkinson Protein 7 (PARK7) antibody

Antigen: Parkinson Protein 7 (PARK7)

Synonyms: DJ1, DJ-1, FLJ27376, FLJ34360, FLJ92274

Clonality: Monoclonal

Host: Rabbit

Reactivity: Human, Rat (Rattus)

Conjugate: Un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP)

Certificates: ISO 9001:2008

Catalog no.: ABIN649643

Additional Information

Alternative name: DJ-1

Description: Other names: PARK7, Protein DJ-1, Oncogene DJ1,Parkinson disease protein 7

Characteristics: Rabbit Monoclonal Antibody

Specificity: A synthetic peptide corresponding to residues near N-terminus of human DJ-1 was used as an immunogen.

Comments:

Background: DJ-1 is ubiquitously expressed in various human tissues, and expression is induced by growth stimuli. Moreover, DJ-1 translocates from cytoplasm to nuclei in the S phase of the cell cycle. DJ-1 is thus suggested to be a novel mitogen-dependent oncogene product involved in a Ras-related signal transduction pathway (1). DJ-1 was first identified as a novel candidate of the oncogene product that transformed mouse NIH3T3 cells in cooperation with an activated ras. Later DJ-1 was also found to be an infertility-related protein that was reduced in rat sperm treated with sperm toxicants that cause infertility in rats. Results of further tests indicate that DJ-1 is a positive regulator of the androgen receptor (2). Mutations in a gene on chromosome 1, DJ-1, have been reported recently to be associated with recessive, earlyonset Parkinson',s disease. The L166P mutation has the simple effect of promoting DJ-1 degradation, thereby reducing net DJ-1 protein within the cell (3).

Application Details

Research Area: Ubiquitin-related antibodies, Signaling, Phospho-specific antibodies, Protein Modifications, Cancer, Neurology, Cell Structure

Restrictions: For Research Use only

Publications

Product: Nagakubo, Taira, Kitaura et al.: "DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ras." in: Biochemical and biophysical research communications, Vol. 231, Issue 2, pp. 509-13, 1997 (PubMed).

Miller, Ahmad, Hague et al.: "L166P mutant DJ-1, causative for recessive Parkinson's disease, is degraded through the ubiquitin-proteasome system." in: The Journal of biological chemistry, Vol. 278, Issue 38, pp. 36588-95, 2003 (PubMed).