Did you know that you can buy products from over 140 different suppliers from us?

Parkinson Protein 7 (PARK7) antibody

Details for Product No. ABIN649643
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Antigen
Synonyms DJ-1, DJ1, CAP1, Dj1, SP22
Reactivity
Human, Rat (Rattus)
(159), (73), (57), (16), (15), (4), (3), (3), (2), (2), (2), (1), (1), (1), (1)
Host
Rabbit
(133), (33), (9)
Clonality
Monoclonal
Conjugate
Un-conjugated
(8), (6), (4), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(156), (98), (42), (39), (23), (21), (10), (10), (10), (2), (1)
Pubmed 2 references available
Quantity 100 µL
Options
Shipping to United States (Change)
Availability Will be delivered in 2 to 3 Business Days
Catalog No. ABIN649643
450.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Specificity A synthetic peptide corresponding to residues near N-terminus of human DJ-1 was used as an immunogen.
Alternative Name DJ-1
Background DJ-1 is ubiquitously expressed in various human tissues, and expression is induced by growth stimuli. Moreover, DJ-1 translocates from cytoplasm to nuclei in the S phase of the cell cycle. DJ-1 is thus suggested to be a novel mitogen-dependent oncogene product involved in a Ras-related signal transduction pathway (1). DJ-1 was first identified as a novel candidate of the oncogene product that transformed mouse NIH3T3 cells in cooperation with an activated ras. Later DJ-1 was also found to be an infertility-related protein that was reduced in rat sperm treated with sperm toxicants that cause infertility in rats. Results of further tests indicate that DJ-1 is a positive regulator of the androgen receptor (2). Mutations in a gene on chromosome 1, DJ-1, have been reported recently to be associated with recessive, earlyonset Parkinson',s disease. The L166P mutation has the simple effect of promoting DJ-1 degradation, thereby reducing net DJ-1 protein within the cell (3).
Synonyms: PARK7, Protein DJ-1, Oncogene DJ1,Parkinson disease protein 7
Research Area Ubiquitin-related antibodies, Signaling, Phospho-specific antibodies, Protein Modifications, Cancer, Neurology, Cell Structure
Comment

Background: DJ-1 is ubiquitously expressed in various human tissues, and expression is induced by growth stimuli. Moreover, DJ-1 translocates from cytoplasm to nuclei in the S phase of the cell cycle. DJ-1 is thus suggested to be a novel mitogen-dependent oncogene product involved in a Ras-related signal transduction pathway (1). DJ-1 was first identified as a novel candidate of the oncogene product that transformed mouse NIH3T3 cells in cooperation with an activated ras. Later DJ-1 was also found to be an infertility-related protein that was reduced in rat sperm treated with sperm toxicants that cause infertility in rats. Results of further tests indicate that DJ-1 is a positive regulator of the androgen receptor (2). Mutations in a gene on chromosome 1, DJ-1, have been reported recently to be associated with recessive, earlyonset Parkinson',s disease. The L166P mutation has the simple effect of promoting DJ-1 degradation, thereby reducing net DJ-1 protein within the cell (3).

Restrictions For Research Use only
Format Liquid
Background publications Nagakubo, Taira, Kitaura et al.: "DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ras." in: Biochemical and biophysical research communications, Vol. 231, Issue 2, pp. 509-13, 1997 (PubMed).

Miller, Ahmad, Hague et al.: "L166P mutant DJ-1, causative for recessive Parkinson's disease, is degraded through the ubiquitin-proteasome system." in: The Journal of biological chemistry, Vol. 278, Issue 38, pp. 36588-95, 2003 (PubMed).

Hosts (133), (33), (9)
Reactivities (159), (73), (57), (16), (15), (4), (3), (3), (2), (2), (2), (1), (1), (1), (1)
Applications (156), (98), (42), (39), (23), (21), (10), (10), (10), (2), (1)
Conjugates (8), (6), (4), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (23), (14), (8), (6), (5), (4), (4), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN649643
450.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
back to top