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Details for Product No. ABIN649644

Parkinson Protein 7 (PARK7) antibody

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Antigen
Synonyms DJ-1, DJ1, CAP1, Dj1, SP22
Reactivity
»Alternatives Human, Rat (Rattus)
Host
»Alternatives Rabbit
Clonality Monoclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FACS)
Pubmed 2 references available
Catalog no. ABIN649644
Quantity 100 ┬ÁL
Price
450.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Specificity A synthetic peptide corresponding to residues near the internal region of human DJ-1 was used as an immunogen.
Alternative Name DJ-1
Background DJ-1 is ubiquitously expressed in various human tissues, and expression is induced by growth stimuli. Moreover, DJ-1 translocates from cytoplasm to nuclei in the S phase of the cell cycle. DJ-1 is thus suggested to be a novel mitogen-dependent oncogene product involved in a Ras-related signal transduction pathway (1). DJ-1 was first identified as a novel candidate of the oncogene product that transformed mouse NIH3T3 cells in cooperation with an activated ras. Later DJ-1 was also found to be an infertility-related protein that was reduced in rat sperm treated with sperm toxicants that cause infertility in rats. Results of further tests indicate that DJ-1 is a positive regulator of the androgen receptor (2). Mutations in a gene on chromosome 1, DJ-1, have been reported recently to be associated with recessive, earlyonset Parkinson',s disease. The L166P mutation has the simple effect of promoting DJ-1 degradation, thereby reducing net DJ-1 protein within the cell (3).
Synonyms: PARK7, Protein DJ-1, Oncogene DJ1,Parkinson disease protein 7
Research Area Ubiquitin-related antibodies, Signaling, Phospho-specific antibodies, Protein Modifications, Cancer, Neurology, Cell Structure
Comment

Background: DJ-1 is ubiquitously expressed in various human tissues, and expression is induced by growth stimuli. Moreover, DJ-1 translocates from cytoplasm to nuclei in the S phase of the cell cycle. DJ-1 is thus suggested to be a novel mitogen-dependent oncogene product involved in a Ras-related signal transduction pathway (1). DJ-1 was first identified as a novel candidate of the oncogene product that transformed mouse NIH3T3 cells in cooperation with an activated ras. Later DJ-1 was also found to be an infertility-related protein that was reduced in rat sperm treated with sperm toxicants that cause infertility in rats. Results of further tests indicate that DJ-1 is a positive regulator of the androgen receptor (2). Mutations in a gene on chromosome 1, DJ-1, have been reported recently to be associated with recessive, earlyonset Parkinson',s disease. The L166P mutation has the simple effect of promoting DJ-1 degradation, thereby reducing net DJ-1 protein within the cell (3).

Restrictions For Research Use only
Background publications Nagakubo, Taira, Kitaura et al.: "DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ras." in: Biochemical and biophysical research communications, Vol. 231, Issue 2, pp. 509-13, 1997 (PubMed).

Takahashi, Taira, Niki et al.: "DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor." in: The Journal of biological chemistry, Vol. 276, Issue 40, pp. 37556-63, 2001 (PubMed).

Alternatives for antigen "Parkinson Protein 7 (PARK7)", type "Antibodies"
Hosts (124), (24), (10)
Reactivities (148), (74), (55), (17), (14), (5), (5), (4), (2), (2), (2), (2), (1), (1), (1)
Applications (145), (91), (37), (31), (17), (17), (12), (10), (6), (3), (2), (1), (1), (1)
Conjugates (5), (4), (4), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (21), (11), (8), (7), (6), (4), (4), (2), (1), (1), (1), (1), (1), (1)
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