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Parkinson Protein 7 (PARK7) antibody

Antigen

Parkinson Protein 7 (PARK7)
Synonyms DJ1, DJ-1, FLJ27376, FLJ34360, FLJ92274
Clonality Monoclonal
Host
Alternatives

Rabbit
Reactivity
Alternatives

Human, Rat (Rattus)
Conjugate
Alternatives Un-conjugated
Application
Alternatives Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FACS)
2 references available
Certificates ISO 9001:2008
Catalog no. ABIN649644
Quantity 100ul  (Variants)
Price 450.00 $   Plus shipping costs $45.00
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Additional Information
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Alternative name DJ-1
Description Other names: PARK7, Protein DJ-1, Oncogene DJ1,Parkinson disease protein 7
Characteristics Rabbit Monoclonal Antibody
Specificity A synthetic peptide corresponding to residues near the internal region of human DJ-1 was used as an immunogen.
Comments

Background: DJ-1 is ubiquitously expressed in various human tissues, and expression is induced by growth stimuli. Moreover, DJ-1 translocates from cytoplasm to nuclei in the S phase of the cell cycle. DJ-1 is thus suggested to be a novel mitogen-dependent oncogene product involved in a Ras-related signal transduction pathway (1). DJ-1 was first identified as a novel candidate of the oncogene product that transformed mouse NIH3T3 cells in cooperation with an activated ras. Later DJ-1 was also found to be an infertility-related protein that was reduced in rat sperm treated with sperm toxicants that cause infertility in rats. Results of further tests indicate that DJ-1 is a positive regulator of the androgen receptor (2). Mutations in a gene on chromosome 1, DJ-1, have been reported recently to be associated with recessive, earlyonset Parkinson',s disease. The L166P mutation has the simple effect of promoting DJ-1 degradation, thereby reducing net DJ-1 protein within the cell (3).

Publications
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Product Nagakubo, Taira, Kitaura et al.: "DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ras." in: Biochemical and biophysical research communications, Vol. 231, Issue 2, pp. 509-13, 1997 (PubMed).

Takahashi, Taira, Niki et al.: "DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor." in: The Journal of biological chemistry, Vol. 276, Issue 40, pp. 37556-63, 2001 (PubMed).

Alternatives
Application Details Publications Variants back to top

Alternatives for antigen "Parkinson Protein 7 (PARK7)", type "Antibodies"
Hosts Rabbit (87), Mouse (13), Goat (6)
Reactivities Human (100), Mouse (Murine) (50), Rat (Rattus) (41), Cow (Bovine) (20), Pig (Porcine) (19), Horse (Equine) (18), Dog (Canine) (4), Chicken (3), Cat (Feline) (1), Chimpanzee (1), Fish (1), Frog (1), Monkey (1), Xenopus laevis (1), Zebrafish (Danio rerio) (1)
Applications Western Blotting (WB) (89), ELISA (62), Immunohistochemistry (IHC) (25), Immunofluorescence (IF) (20), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (19), Immunocytochemistry (ICC) (7), Immunoprecipitation (IP) (7), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Immunoelectron Microscopy (IEM) (1), Immunohistochemistry (Fixed) (IHC (fx)) (1), Immunohistochemistry (Frozen Sections) (IHC (fro)) (1)
Conjugates Biotin (5), FITC (2), HRP (2), Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), Gold (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1)
Epitopes C-Term (9), Internal Region (6), N-Term (3), AA 167-189 (2), AA 177-189 (2), AA 1-189 (1), AA 178-189 (1), AA 50-100 (1), Center (1), N-Term, AA 167-189 (1)