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Dynein, Light Chain, LC8-Type 1 (DYNLL1) (N-Term) antibody

Details for Product No. ABIN649645
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Antigen
Synonyms DLC1, DLC8, DNCL1, DNCLC1, LC8, LC8a, PIN, hdlc1, Pin, Dlc8, Dnclc1, 8kDLC, CDLC2, dlc1, dlc8, dncl1, dnclc1, dynll1, dynll1b, lc8, lc8a, dynll1a, MGC68763, pin, MGC89636, DYNLL1
Epitope
N-Term
(6), (2), (2), (2), (1), (1), (1), (1)
Reactivity
Human, Rat (Rattus)
(44), (25), (20), (15), (12), (4), (3), (2), (2), (2), (1), (1)
Host
Rabbit
(40), (6), (2), (1)
Clonality
Monoclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(34), (16), (13), (10), (7), (6), (6), (4), (2), (1)
Pubmed 3 references available
Quantity 100 µL
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Catalog No. ABIN649645
450.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Specificity A synthetic peptide corresponding to residues on the N-terminus of human DLC8 was used as an immunogen.
Alternative Name DLC8
Background DLC8 protein bound efficiently to gephyrin in in vitro binding assays and colocalized with gephyrin during coexpression in HEK293 cells. The binding site for DLC8 was mapped to a fragment of 63 amino acids within the central linker domain of gephyrin. In hippocampal neurons, endogenous DLC8 protein was enriched at synaptic sites identified by synaptophysin and gephyrin immunostaining. Because DLC8 has been described as stoichiometric components of cytoplasmic dynein and myosin-Va complexes, results suggest that motor proteins are involved in the subcellular localization of gephyrin (1). DLC8 was identified as a transport molecule in the cytoplasm. DLC8 co-localizes with TRPS1 in dot-like structures in the cell nucleus. In an electrophoretic mobility shift assay it was shown that the interaction of DLC8 and TRPS1 lowers the binding of TRPS1 to the GATA consensus sequence. In addition DLC8 is able to suppress the transcriptional repression activity of TRPS1 (2).
Synonyms: DYNLL1, DLC1, DNCL1, DNCLC1, HDLC1, Dynein light chain 1, cytoplasmic, Dynein light chain LC8-type 1,8 kDa dynein light chain,DLC8,Protein inhibitor of neuronal nitric oxide synthase
Research Area Translation Factors, Signaling, Phospho-specific antibodies, Protein Modifications, Transcription Factors, Cell Structure
Comment

Background: DLC8 protein bound efficiently to gephyrin in in vitro binding assays and colocalized with gephyrin during coexpression in HEK293 cells. The binding site for DLC8 was mapped to a fragment of 63 amino acids within the central linker domain of gephyrin. In hippocampal neurons, endogenous DLC8 protein was enriched at synaptic sites identified by synaptophysin and gephyrin immunostaining. Because DLC8 has been described as stoichiometric components of cytoplasmic dynein and myosin-Va complexes, results suggest that motor proteins are involved in the subcellular localization of gephyrin (1). DLC8 was identified as a transport molecule in the cytoplasm. DLC8 co-localizes with TRPS1 in dot-like structures in the cell nucleus. In an electrophoretic mobility shift assay it was shown that the interaction of DLC8 and TRPS1 lowers the binding of TRPS1 to the GATA consensus sequence. In addition DLC8 is able to suppress the transcriptional repression activity of TRPS1 (2).

Restrictions For Research Use only
Format Liquid
Product cited in: Jia, Fong, Choi et al.: "Dynamic Recruitment of CDK5RAP2 to Centrosomes Requires Its Association with Dynein." in: PLoS ONE, Vol. 8, Issue 7, pp. e68523, 2013 (PubMed).

Background publications Fuhrmann, Kins, Rostaing et al.: "Gephyrin interacts with Dynein light chains 1 and 2, components of motor protein complexes." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 22, Issue 13, pp. 5393-402, 2002 (PubMed).

Kaiser, Tavassoli, Van den Bemd et al.: "Nuclear interaction of the dynein light chain LC8a with the TRPS1 transcription factor suppresses the transcriptional repression activity of TRPS1." in: Human molecular genetics, Vol. 12, Issue 11, pp. 1349-58, 2003 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN649645
450.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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